Clarison 500mg (Tablet)
Manufactured by: Hudson Pharmaceuticals Ltd.
Clarithromycin Similar medicine
Clarison is indicated for
- Respiratory tract infections
- Skin
- soft tissue infections
- Leprosy
- peptic ulcer disease
- pharyngitis
- tonsillitis
- acute maxillary sinusitis
- acute bacterial exacerbation of chronic bronchitis
- pneumonia
- legionellosis
- Helicobacter pylori
- lyme disease
- Community-Acquired Pneumonia
Precautions and warnings
This medicine has potential side effects and precautions that should be taken. Here are some of the precautions that should be considered when taking clarithromycin:
Allergies: If you are allergic to clarithromycin or any other macrolide antibiotics, you should not take this medication.
Liver or kidney problems: Clarithromycin can affect liver and kidney function. If you have liver or kidney disease, your doctor may need to adjust your dose or monitor you closely while you are taking this medication.
Heart problems: Clarithromycin can cause changes in the heart's rhythm, especially in people who have a history of heart problems. If you have a heart condition, talk to your doctor before taking clarithromycin.
Pregnancy and breast-feeding: Clarithromycin should only be used during pregnancy or breastfeeding if the potential benefits outweigh the potential risks.
Other medications: Clarithromycin can interact with other medications, including blood thinners, cholesterol-lowering drugs, and drugs used to treat HIV. Be sure to tell your doctor about all medications you are taking before starting clarithromycin.
Avoid alcohol: Clarithromycin should not be taken with alcohol as it may increase the risk of side effects such as stomach upset and dizziness.
Avoid driving: Clarithromycin can cause dizziness and other side effects that may impair your ability to drive or operate machinery. Avoid these activities until you know how the medication affects you.
It's important to follow your doctor's instructions when taking clarithromycin and to report any side effects you experience.
Side-effects
- GI upset
- glossitis
- stomatitis
- altered taste
- headache
- dizziness
- hallucinations
- insomnia
- other CNS effects
- rash
- hepatic dysfunction
- Potentially Fatal: Pseudomembranous colitis
- anaphylaxis
- Stevens-Johnson syndrome
Drug Interactions
Clarithromycin can interact with other medications and substances, which can affect its effectiveness and increase the risk of side effects. Here are some of the common interactions of clarithromycin:
Warfarin: Clarithromycin can increase the effects of warfarin, a blood thinner, and increase the risk of bleeding. Your doctor may need to monitor your INR (International Normalized Ratio) more closely if you are taking both medications.
Colchicine: Clarithromycin can increase the risk of side effects of colchicine, a medication used to treat gout. This can lead to serious side effects such as muscle weakness, neuropathy, and myopathy. If you are taking both medications, your doctor may need to adjust your dose of colchicine.
Digoxin: Clarithromycin can increase the blood levels of digoxin, a medication used to treat heart failure and irregular heartbeat. This can lead to toxicity and serious side effects such as nausea, vomiting, and arrhythmias. Your doctor may need to monitor your digoxin levels more closely if you are taking both medications.
Statins: Clarithromycin can increase the blood levels of statins, a class of cholesterol-lowering medications. This can increase the risk of muscle damage and kidney damage. Your doctor may need to adjust your dose of statins or switch to a different medication.
Antacids: Clarithromycin should not be taken with antacids containing aluminum or magnesium, as they can reduce the absorption of clarithromycin and decrease its effectiveness.
Grapefruit juice: Grapefruit juice can increase the blood levels of clarithromycin and increase the risk of side effects. It is recommended to avoid grapefruit juice while taking clarithromycin.
Potentially Fatal: Concurrent use of ergot alkaloids (e.g. ergotamine or dihydroergotamine) is associated with acute ergot toxicity characterized by vasospasm and ischemia of the extremities. Concomitant use with astemizole, cisapride, pimozide and terfenadine may result in QT prolongation or ventricular cardiac arrhythmia.
Contraindications
There are several contraindications to the use of clarithromycin, which means that the medication should not be used in certain individuals or under certain conditions. Here are some of the contraindications of clarithromycin:
Hypersensitivity: Clarithromycin is contraindicated in individuals who are hypersensitive to it or any other macrolide antibiotics.
Concomitant use with certain medications: Clarithromycin is contraindicated in individuals who are taking certain medications such as ergotamine or dihydroergotamine, due to the risk of serious side effects such as ergotism.
Myasthenia gravis: Clarithromycin is contraindicated in individuals with myasthenia gravis, a neuromuscular disorder that causes weakness and fatigue in muscles.
Severe liver impairment: Clarithromycin is contraindicated in individuals with severe liver impairment as the medication is metabolized in the liver.
Long QT syndrome: Clarithromycin is contraindicated in individuals with a history of prolonged QT syndrome or other cardiac arrhythmias.
Pregnant and breastfeeding women: Clarithromycin is contraindicated in pregnant and breastfeeding women unless the benefits outweigh the risks and under the supervision of a healthcare provider.
Mode of actions
Clarithromycin is a macrolide antibiotic that works by inhibiting the growth and spread of bacteria in the body. Its mode of action involves binding to the bacterial ribosome, which is responsible for the synthesis of proteins essential for the growth and survival of the bacteria. By binding to the ribosome, clarithromycin prevents the bacteria from producing proteins, which eventually leads to their death.
Specifically, clarithromycin binds to the 50S subunit of the bacterial ribosome and interferes with the translocation of the peptidyl-tRNA from the acceptor site to the donor site. This results in the premature release of incomplete polypeptide chains, which cannot function as fully formed proteins, and thus, the bacteria cannot survive.
Clarithromycin is effective against a wide range of bacteria, including Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Mycoplasma pneumoniae, among others. It is commonly used to treat respiratory tract infections, skin infections, and other bacterial infections.
Dosage & Administration
Adult: PO Resp tract infections; Skin and soft tissue infections; Susceptible infections 250 mg twice daily, up to 500 mg twice daily for severe infections, for 7-14 days.
Mycobacterium avium complex infections W/ other antimycobacterials: 500 mg twice daily. Leprosy As part of multidrug therapy: 500 mg/day.
H. pylori infection W/ another antibacterial and either a proton pump inhibitor or H2 antagonist: 500 mg twice daily for 7-14 days.
IV Resp tract infections; Skin and soft tissue infections; Susceptible infections 500 mg twice daily for 2-5 days.
Child: 7.5 mg/kg bid for 5-10 days.
Renal impairment:
CrCl (ml/min)
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.
Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.
This medicine passes into breast milk. Talk to your doctor before breastfeeding.
Pack Size & Price
10's pack Price : ৳450
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