Clarison 500mg (Tablet)
Manufactured by: Hudson Pharmaceuticals Ltd.
Clarithromycin Similar medicine
Clarison is indicated for
- 呼吸道感染、皮膚和軟組織感染、麻風病、消化性潰瘍病、咽炎、扁桃體炎、急性上顎竇炎、慢性支氣管炎急性細菌性惡化、肺炎、退伍軍人症、幽門螺旋桿菌、萊姆病、社區型肺炎
Precautions and warnings
該藥具有潛在的副作用和應採取的預防措施。 以下是服用克拉黴素時應考慮的一些預防措施：
過敏：如果您對克拉黴素或任何其他大環內酯類抗生素過敏，則不應服用這種藥物。
肝臟或腎臟問題：克拉黴素會影響肝臟和腎臟功能。 如果您患有肝臟或腎臟疾病，您的醫生可能需要在您服用這種藥物時調整您的劑量或密切監測您。
心臟問題：克拉黴素會導致心律改變，尤其是有心臟問題病史的人。 如果您患有心臟疾病，請在服用克拉黴素之前諮詢您的醫生。
懷孕和哺乳：只有在潛在益處大於潛在風險的情況下，才應在懷孕或哺乳期間使用克拉黴素。
其他藥物：克拉黴素可以與其他藥物產生交互作用，包括血液稀釋劑、降膽固醇藥物和用於治療愛滋病毒的藥物。 在開始使用克拉黴素之前，請務必告訴您的醫生您正在服用的所有藥物。
避免飲酒：克拉黴素不應與酒精一起服用，因為它可能會增加胃部不適和頭暈等副作用的風險。
避免駕駛：克拉黴素會導致頭暈和其他副作用，可能會損害您駕駛或操作機器的能力。 在您知道藥物對您有何影響之前，請避免這些活動。
服用克拉黴素時遵循醫生的指示並報告您遇到的任何副作用非常重要。
Side-effects
- 胃腸道不適、舌炎、口腔炎、味覺改變、頭痛、頭暈、幻覺、失眠、其他中樞神經系統影響、皮疹、肝功能障礙、 潛在致命：偽膜性結腸炎、過敏反應、史蒂文斯-約翰遜症候群
Drug Interactions
克拉黴素可以與其他藥物和物質相互作用，從而影響其有效性並增加副作用的風險。 以下是克拉黴素的一些常見交互作用：
華法林：克拉黴素可以增強華法林（一種血液稀釋劑）的作用，增加出血風險。 如果您同時服用這兩種藥物，您的醫生可能需要更密切地監測您的 INR（國際標準化比率）。
秋水仙鹼：克拉黴素會增加秋水仙鹼（一種用於治療痛風的藥物）的副作用風險。 這可能會導致嚴重的副作用，例如肌肉無力、神經病變和肌肉病變。 如果您同時服用這兩種藥物，您的醫師可能需要調整秋水仙鹼的劑量。
地高辛：克拉黴素可以增加地高辛的血液濃度，地高辛是一種用於治療心臟衰竭和心律不整的藥物。 這可能會導致毒性和嚴重的副作用，例如噁心、嘔吐和心律不整。 如果您同時服用這兩種藥物，您的醫生可能需要更密切地監測您的地高辛水平。
他汀類藥物：克拉黴素可以增加他汀類藥物的血液水平，他汀類藥物是一類降膽固醇藥物。 這會增加肌肉損傷和腎臟損傷的風險。 您的醫師可能需要調整他汀類藥物的劑量或改用其他藥物。
抗酸劑：克拉黴素不應與含有鋁或鎂的抗酸劑一起服用，因為它們會減少克拉黴素的吸收並降低其有效性。
葡萄柚汁：葡萄柚汁會增加克拉黴素的血液濃度並增加副作用的風險。 建議服用克拉黴素時避免飲用葡萄柚汁。
可能致命：同時使用麥角生物鹼（如麥角胺或二氫麥角胺）會導致急性麥角毒性，其特徵是血管痙攣和四肢缺血。 與阿斯咪唑、西沙必利、匹莫齊特和特非那丁併用可能導致 QT 間期延長或室性心律不整。
Contraindications
使用克拉黴素有幾個禁忌症，這意味著該藥物不應在某些個體或某些條件下使用。 以下是克拉黴素的一些禁忌症：
過敏：對克拉黴素或任何其他大環內酯類抗生素過敏的個體禁用克拉黴素。
與某些藥物同時使用：克拉黴素禁用於正在服用某些藥物（例如麥角胺或二氫麥角胺）的個人，因為有嚴重副作用（例如麥角中毒）的風險。
重症肌無力症：重症肌無力患者禁用克拉黴素，重症肌無力是神經肌肉疾病，會導致肌肉無力和疲勞。
嚴重肝損傷：克拉黴素禁用於嚴重肝損傷的個體，因為藥物在肝臟代謝。
長QT症候群：有QT間期延長症候群或其他心律不整病史的個體禁用克拉黴素。
孕婦和哺乳期婦女：克拉黴素禁用於孕婦和哺乳期婦女，除非益處大於風險並且在醫療保健提供者的監督下。
Mode of actions
克拉黴素是一種大環內酯類抗生素，透過抑制體內細菌的生長和傳播而發揮作用。 其作用方式涉及與細菌核醣體結合，核醣體負責合成細菌生長和生存所必需的蛋白質。 透過與核醣體結合，克拉黴素可阻止細菌產生蛋白質，最終導致細菌死亡。
具體來說，克拉黴素與細菌核醣體的 50S 亞基結合，幹擾肽基-tRNA 從受體位點到供體位點的易位。 這導致不完整的多肽鏈過早釋放，無法發揮完全形成的蛋白質的作用，因此細菌無法生存。
克拉黴素對多種細菌有效，包括肺炎鏈球菌、流感嗜血桿菌、卡他莫拉菌和肺炎支原體等。 它通常用於治療呼吸道感染、皮膚感染和其他細菌感染。
Dosage & Administration
成人：PO 呼吸道感染；皮膚和軟組織感染；敏感感染250毫克每天兩次，嚴重感染最多500毫克每天兩次，持續7-14天。
鳥分枝桿菌複合感染與其他抗分枝桿菌藥物合併使用：500 mg，每日兩次。 麻風病 作為多種藥物治療的一部分：500 毫克/天。
幽門螺旋桿菌感染，使用另一種抗菌藥物和質子幫浦抑制劑或 H2 拮抗劑：500 毫克，每日兩次，持續 7-14 天。
IV 呼吸道感染；皮膚和軟組織感染；敏感感染者 500 mg，每日兩次，持續 2-5 天。
兒童：7.5 mg/kg bid，5-10 天。
腎功能損害：
CrCl (毫升/分鐘)
Pregnancy & Lactation
儘管動物生殖研究顯示對胎兒有不良影響，並且在孕婦中沒有充分且良好對照的研究，但在懷孕期間，儘管存在潛在風險，但在確實需要時可以使用該藥物。
在懷孕最後 3 個月內使用這種藥物的新生兒母親可能很少會出現困倦、肌肉僵硬或顫抖、餵食或呼吸困難、持續哭泣等症狀。 如果您發現寶寶有任何這些症狀，尤其是在第一個月內，請立即告訴醫生。
這種藥物會進入母乳。 哺乳前請先諮詢您的醫生。
Pack Size & Price
10's pack Price : ৳450
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