IMBAC IV/IM (Injection)
Manufactured by: Popular Pharmaceuticals Ltd.
Cilastatin + Imipenem Similar medicine
IMBAC IV/IM is indicated for
- Fibrose kystique
- septicémie bactérienne
- endocardite
- infections sensibles
- infections des voies respiratoires inférieures
- gonorrhée
- infections de la peau et des structures cutanées
- infections des voies urinaires
- infections des os et des articulations
- prophylaxie chirurgicale
Precautions and warnings
Soyez prudent lorsque vous administrez ce médicament à des patients allergiques à d'autres antibiotiques bêta-lactamines, car ils pourraient également réagir à ce médicament. Utiliser avec prudence chez les personnes souffrant de maladies telles que l'épilepsie ou des problèmes rénaux ou hépatiques. Faites particulièrement attention si la patiente est enceinte ou si elle allaite.
Side-effects
- Éruptions cutanées
- urticaire
- éosinophilie
- fièvre
- nausées
- vomissements
- diarrhée
- décoloration des dents ou de la langue et altération du goût. Érythème polymorphe
- dermatite exfoliative. Des douleurs et une thrombophlébite peuvent survenir au site d'injection. Potentiellement mortel : syndrome de Stevens-Johnson
- nécrolyse épidermique toxique.
Drug Interactions
La prise de probénécide en même temps que la cilastatine peut permettre à la cilastatine de rester plus longtemps dans l'organisme. L'utilisation de la cilastatine avec le ganciclovir peut augmenter le risque de convulsions.
Mode of actions
L'imipénème est un antibiotique puissant qui tue de nombreux types de bactéries en les empêchant de construire leurs parois cellulaires. Il fonctionne bien car il n’est pas dégradé par certaines enzymes (appelées ?-lactamases) que de nombreuses bactéries utilisent pour se protéger. La cilastatine est un médicament qui bloque une enzyme présente dans les reins (appelée déshydropeptidase I). Lorsque l’imipénème est administré avec la cilastatine, il aide à empêcher sa dégradation dans les reins et protège contre les lésions rénales. Les deux médicaments sont administrés sous forme de sels de sodium.
Dosage & Administration
Adulte : IV Infections sensibles Sous forme d'imipénem : 1 à 2 g/jour en doses fractionnées 6 à 8 heures. Prophylaxie chirurgicale Comme imipénème : 1 g dès l'induction de l'anesthésie, suivi de 1 g 3 heures plus tard. Des doses supplémentaires de 500 mg peuvent être administrées 8 et 16 heures après l'induction si nécessaire.
Enfant : >40 kg : identique à la dose adulte. >3 mois et
Pregnancy & Lactation
Bien que des études sur la reproduction animale aient montré un effet indésirable sur le fœtus et qu'il n'existe pas d'études adéquates et bien contrôlées chez la femme enceinte, ce médicament peut être utilisé pendant la grossesse juste lorsque cela est absolument nécessaire, malgré les risques potentiels.
Les mères d'un nouveau-né qui ont utilisé ce médicament au cours des 3 derniers mois de leur grossesse peuvent rarement créer des symptômes tels que somnolence, raideur ou tremblements musculaires, troubles de l'alimentation ou de la respiration, pleurs constants. Si vous remarquez l'un de ces symptômes chez votre bébé, en particulier au cours de son premier mois, informez-en immédiatement le médecin.
Ce médicament passe dans le lait maternel. Parlez-en à votre médecin avant d'allaiter.
Pack Size & Price
500mg vial X 1's pack Price : ৳1199.51
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