Precautions and warnings

History of mania or seizure disorders; act requiring knowledge alertness; renal and hepatic impairment; pregnancy, lactation; draw gradually, Children and adolescents.

Drug Interactions

Increased risk of bleeding when used with aspirin, NSAIDs or drugs that impact coagulation, Serum levels may be reduced by CYP2C19 inducers (for example, carbamazepine, rifampin, phenytoin) or CYP3A4 inducers (for example, nafcillin, nevirapine),Serum levels may also be increased by CYP2C19 inhibitors (for example, fluconazole, fluvoxamine, omeprazole) or CYP3A4 inhibitors (for example, azalea antifungals, clarithromycin), May increase serum levels of desipramine or metoprolol, Increased risk of serotonin syndrome when used with linezolid or sibutramine, Escitalopram may raise the ataraxic effects of alcohol, Potentially Fatal: Concomitant administration with MAOIs may head to serious or black reactions; should not be started until at least 2 week after stopping escitalopram or vice versa,Moclobemide may increase the risk of serotonin syndrome.

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Contraindications

Concomitant use with or within 2 wk of MAOI withdrawal.

Mode of actions

Escitalopram selectively inhibits CNS neuronic re-uptake of serotonin (5-HT) and potentiates serotonergic activity, It has minimal effects on norepinephrine and dopamine neural re-uptake.

Dosage & Administration

Adult: PO Depression; Anxiety; Obsessive compulsive disorder 10 mg once daily. Max: 20 mg/day.
Panic disorder Initial: 5 mg/day, up to 10 mg/day after 7 days if needed. Max: 20 mg/day.

Elderly: Half the adult dose.
Hepatic impairment: Dosage adjustments may be required.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

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