Pza Ciba 500mg (Tablet)
Manufactured by: Novartis (Bangladesh) Ltd.
Pyrazinamide Similar medicine
Pza Ciba is indicated for
- Tuberculosis
Precautions and warnings
People with diabetes, kidney problems, gout, or children should have their liver function and uric acid levels checked regularly.
Side-effects
- Hepatotoxicity (hepatomegaly
- splenomegaly
- jaundice may develop
- in rare case fulminating acute yellow atrophy
- death). Anorexia
- nausea
- vomiting
- arthralgia
- malaise
- fever
- hyperuricaemia
- abnormal LFT
- skin rashes. Potentially Fatal: Severe liver damage
- fulminant hepatitis.
Contraindications
Do not use if you have allergies (hypersensitivity), liver problems, acute gout, high uric acid levels, or porphyria. Avoid during pregnancy and breastfeeding.
Mode of actions
Pyrazinamide can either stop bacteria from growing (bacteriostatic) or kill them (bactericidal), depending on how much of the drug reaches the infection and how sensitive the bacteria are. The drug works mainly by turning into another substance called pyrazinoic acid (POA), which makes the environment more acidic. This acidic environment stops Mycobacterium tuberculosis from growing. The bacteria that are affected by pyrazinamide have an enzyme called pyrazinamidase, which changes pyrazinamide into POA. How well the bacteria respond to pyrazinamide in laboratory tests depends on how much of this enzyme they have.
Dosage & Administration
Oral
Tuberculosis
Adult: As part of a multidrug regimen: For standard unsupervised 2-mth treatment: 50 kg: 2 g daily. For intermittent supervised 2-mth treatment:
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.
Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.
This medicine passes into breast milk. Talk to your doctor before breastfeeding.
Pack Size & Price
100's pack Price : ৳235
Similar medicine
Manufactured by: Novartis (Bangladesh) Ltd.
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