Precautions and warnings

This medication should only be given by a doctor who is experienced with cancer chemotherapy. Take special care when handling and disposing of it. Watch the patient’s nerve function closely, and lower the dose if nerve symptoms last a long time or are very bad. Regularly check blood cell counts during treatment, and do not give another dose until blood counts are back to normal. Use caution in elderly patients and those with moderate kidney problems. Do not use needles or IV sets that contain aluminum, because aluminum can break down this medicine. Avoid using during breastfeeding.

Drug Interactions

It may lower the amount of digoxin in the blood. It may also raise the risk of harmful effects when used with drugs that can damage the kidneys. When given as one after another, taxane drugs (such as docetaxel and paclitaxel) should be given before oxaliplatin. This helps reduce the risk of low blood cell counts and makes the treatment work better.

Contraindications

Pregnancy. Nerve problems that affect movement or daily activities. Serious kidney problems.

Mode of actions

Oxaliplatin is a drug that contains platinum, much like cisplatin, and works as an alkylating agent. Once it enters the cell and breaks down, it attaches to DNA and forms links between DNA strands. This blocks the DNA from being copied or used to make proteins, which eventually leads to the cell dying.

Dosage & Administration

Intravenous
Advanced colorectal cancer
Adult: In combination with fluorouracil/leucovorin: 85 mg/m2 every 2 wk until disease progression or unacceptable toxicity. Dose to be given by IV infusion over 2-6 hr, dissolved in 250-500 ml of glucose 5%, . After recovery from toxicity, reduce dose to 65 mg/m2. Administer before fluoropyrimidines.

Adjuvant therapy in stage III colon cancer
Adult: In combination with fluorouracil/leucovorin: 85 mg/m2 every 2 wk for 12 cycles. Dose to be given by IV infusion over 2-6 hr, dissolved in 250-500 ml of glucose 5%, every 2 wk; given for 12 cycles. After recovery from toxicity, reduce dose to 75 mg/m2. Administer before fluoropyrimidines.

Pregnancy & Lactation

This medicine is not allowed during pregnancy. Do not use it if you are pregnant. It can be absorbed through the skin and lungs caused can damage your unborn child’s organs and cause congenital disabilities. Strict effective birth control during treatment and for six months after stopping this medicine. If you do become pregnant, stop taking this medicine and discuss your doctor right away.

There is no specific information on whether this medicine passes into breast milk or not. Considering the possible risks for the children, breastfeeding while using this medicine is not recommended and at least two weeks after the last dose. Consult your doctor before breastfeeding.

Pack Size & Price