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Nyclobate (Cream)

Manufactured by: Incepta Pharmaceuticals Ltd.

Clobetasol Propionate 0.05% Similar medicine

Nyclobate is indicated for

  • Corticosteroid-responsive Dermatoses
  • Psoriasis
  • Scalp Psoriasis
  • Plaque-type Psoriasis
  • Vitiligo
  • Eczema
  • Alopecia areata
  • Herpes labialis
  • Lichen sclerosus
  • Lichen
  • Mycosis fungoides
  • Corticosteroid-responsive dermatoses

Precautions and warnings

Tell your doctor about your medical history, especially if you have poor blood circulation, immune system difficulties, or certain skin conditions, before using this drug.

If the region to be treated has an infection or a sore, don't use it.

Corticosteroid drugs can make it more difficult for your body to respond to physical stress if you use them for a long time or over a big region of skin. Tell your doctor or dentist if you are taking this drug or have taken it in the last few months before undergoing surgery or emergency treatment, or if you have a serious illness or accident.

If used for an extended period of time, this medication may cause a child's growth to be slowed momentarily. Regularly see the doctor to get your child's height measured.

Side-effects

  • Perioral dermatitis
  • striae esp in flexures. Dermal
  • epidermal atrophy esp on the face
  • steroid purpura. Potentially Fatal: Prolonged usage of large amount of clobetasol propionate can lead to sufficient systemic levels to produce adrenal suppression
  • Cushing's syndrome
  • diabetes
  • hypertension.

Drug Interactions

Corticosteroids for example prednisone and medications that suppress the immune system are examples of items that may interact with this medication for instance cyclosporine.

Mode of actions

Corticosteroids reduce inflammation by stabilizing leukocyte lysosomal membranes, inhibiting macrophage accumulation in inflamed areas, reducing leukocyte adhesion to capillary endothelium, reducing capillary wall permeability and edema formation, decreasing complement components, antagonizing histamine activity and kinin release from substrates, and reducing fibroblast proliferation and collagen deposition.

Dosage & Administration

Adults and children over 1 year:
Apply sparingly to cover the affected area, and gently rub into the skin. Frequency of application is 2 to 3 times daily according to the severity of the condition. The total dose applied should not exceed 50 g weekly.

Treatment should not be continued for more than 7 days without medical supervision. If a longer course is necessary, it is recommended that treatment should not be continued for more than 4 weeks without the patient's condition being reviewed.

Repeated short courses of Clobetasol may be used to control exacerbations
Children below 1 year: Under 1 year this preparation is not recommended.

Scalp Application
It should be applied to the affected scalp areas twice daily, once in morning and once at night.
Total dosage should not exceed 50 ml per week.
As with other highly active topical steroid preparations, therapy should be discontinued when control is achieved
Children: Under 1 year this preparation is not recommended.

Shampoo
It should be applied to the dry (not wet) scalp once a day to the affected areas only.
It should be massaged gently into the lesions and left in place for 15 minutes before lathering and rinsing.
Treatment should be limited to 4 consecutive weeks.
Total dosage of shampoo should not exceed 50 g per week.
Under 18 years this preparation is not recommended.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

Pack Size & Price

10gm tube/ 20gm tube Price : ৳45/70

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Click here to see 43 more similar medicines

There are few similar medicines of Nyclobate are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.