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Ace PLUS (Tablet)

Manufactured by: Square Pharmaceuticals Ltd.

Paracetamol + Caffeine Similar medicine

Ace PLUS is indicated for

  • Pain
  • Fever
  • Headache
  • Influenza
  • Migraine
  • Sore throat
  • Backache
  • Toothache
  • Rheumatic pain
  • Dysmenorrhea
  • Colds

Precautions and warnings

This drug has the severe hepatic or renal disorder. Such as:

Anxiety disorders:
Caffeine may aggravate these symptoms. Use it with caution.

Bipolar disorder:
Too much caffeine may exacerbate the disease.

Caffeine and bleeding disorders:
Caffeine has been linked to an increase in bleeding problems. If you have a bleeding issue, use coffee with caution.

irregular heartbeat:
Caffeine can cause irregular heartbeat in persons who are hypersensitive to it. Caffeine should be used with caution.

Sugar absorption: Caffeine may impact the way the body absorbs sugar, potentially worsening diabetes, according to some research. Caffeinated beverages and supplements, on the other hand, have not been investigated. Caffeine should be used with caution if you have diabetes.

Diarrhea patient:
Caffeine may aggravate diarrhea, especially when used in excessive amounts.

Epilepsy: Caffeine should be avoided in excessive dosages by people who have epilepsy. Caffeine in low amounts should be used with caution.

Glaucoma patient:
Caffeine causes glaucoma by raising the pressure inside the eye. After ingesting caffeinated beverages, the increase occurs within 40 minutes and lasts for at least 90 minutes.

Blood pressure:
Caffeine use may raise blood pressure in persons who already have high blood pressure. This effect, however, may be diminished in persons who consume caffeine on a daily basis.

Bladder control problems:
Caffeine can exacerbate bladder control problems by increasing the frequency of urination and the desire to urinate.

Irritable bowel syndrome:
Caffeine, especially in excessive doses, may aggravate diarrhea.

Caffeine can increase the quantity of calcium washed out in the urine, which can lead to weak bones (osteoporosis). Caffeine should be limited to less than 300 mg per day if you have osteoporosis or low bone density (approximately 2-3 cups of coffee). It's also a good idea to get extra calcium to compensate for any calcium lost through urine. Taking up to 400 mg of caffeine per day (3-5 cups of coffee) does not appear to raise the risk of developing osteoporosis if you are otherwise healthy and get enough calcium from food or supplements. Caffeine should be used with caution by older women who have a hereditary condition that affects the way vitamin D is used. Vitamin D helps to develop strong bones by combining with calcium.

Caffeine is possibly safe when administered to premature infants by mouth or intravenously under the supervision and care of a healthcare expert. Caffeine is also possibly safe when consumed at amounts found in foods by children and teenagers.

Caffeine is possibly safe in pregnant or breastfeeding women when used in daily doses of less than 300 mg. This is roughly equivalent to 3 cups of coffee. It is possibly safe to consume greater amounts during pregnancy or while breastfeeding. Caffeine, when ingested in significant amounts during pregnancy, may raise the risk of miscarriage and other complications. Caffeine can also transfer into breast milk, therefore nursing women should keep a close eye on their caffeine intake to ensure it is kept to a minimum. In breast-fed infants, a high caffeine intake by nursing mothers might cause sleep problems, irritability, and increased bowel activity.

Caffeine may exacerbate the symptoms of schizophrenia.

Side-effects

  • Skin rash
  • diarrhoea
  • anorexia
  • GI disturbances
  • epistaxis (rare).

Drug Interactions

DO NOT TAKE THIS COMBINATION

Ephedrine and caffeine: Stimulant medications such as ephedrine and caffeine stimulate the neural system. Both caffeine and ephedrine are stimulants. Caffeine combined with ephedrine may result in excessive excitement, as well as dangerous side effects including heart difficulties. Caffeine-containing products and ephedrine should not be taken at the same time.



MODERATE INTERACTION

Clozapine and caffeine:
Clozapine (Clozaril) is broken down by the body to get rid of it. Caffeine appears to slow down the breakdown of clozapine in the body (Clozaril). Caffeine can increase the effects and adverse effects of clozapine (Clozaril) when used together (Clozaril).

Estrogens and caffeine:
To get rid of caffeine, the body breaks it down. Estrogens can slow down the breakdown of caffeine in the body. Caffeine combined with estrogens can produce jitteriness, headaches, a racing heart, and other unpleasant side effects. Caffeine should be avoided if you are taking estrogens.

Adenosine and caffeine:
Caffeine may counteract adenosine's effects (Adenocard). Doctors frequently employ adenosine (Adenocard) to perform a cardiac test. A cardiac stress test is a name for this procedure. Caffeine-containing items should be avoided for at least 24 hours before a heart stress test.

Disulfiram and caffeine:
To get rid of caffeine, the body breaks it down. The drug disulfiram (Antabuse) can slow down the body's elimination of caffeine. Caffeine used with disulfiram (Antabuse) may increase the effects and negative effects of caffeine, such as jitteriness, hyperactivity, and irritability.

Antibiotics and caffeine:
To get rid of caffeine, the body breaks it down. Some antibiotics may slow down the breakdown of caffeine in the body. When these antibiotics are used with coffee, they might cause jitteriness, headaches, an elevated heart rate, and other side effects.

Cimetidine and caffeine:
To get rid of caffeine, the body breaks it down. Cimetidine (Tagamet) slows down the breakdown of caffeine in your body. When used with caffeine, cimetidine (Tagamet) may enhance the risk of caffeine side effects such as jitteriness, headache, rapid heartbeat, and others.

Dipyridamole and caffeine:
Caffeine may interfere with dipyridamole's effects (Persantine). Doctors frequently employ Dipyridamole (Persantine) to perform a cardiac test. A cardiac stress test is a name for this procedure. Caffeine-containing items should be avoided for at least 24 hours before a heart stress test.

Phenylpropanolamine and caffeine:
Caffeine has the ability to activate the body. The body can also be stimulated by phenylpropanolamine. Caffeine combined with phenylpropanolamine may induce excessive excitement, resulting in a rise in heart rate, blood pressure, and nervousness.

Fluvoxamine and caffeine:
To get rid of caffeine, the body breaks it down. Fluvoxamine (Luvox) can slow down the breakdown of caffeine in the body. Taking caffeine with fluvoxamine (Luvox) may result in an excess of caffeine in the body, as well as an increase in caffeine's effects and negative effects.

Lithium and caffeine:
Lithium is naturally excreted by the body. Caffeine might hasten the removal of lithium from your body. If you're taking lithium and using caffeine-containing goods, reduce your caffeine intake gradually. Caffeine withdrawal can exacerbate the negative effects of lithium.

Theophylline and caffeine:
Caffeine functions in the same way that theophylline does. Caffeine can also slow down the body's elimination of theophylline. Taking theophylline with caffeine may increase theophylline's effects and adverse effects.

Pentobarbital and caffeine:
Caffeine's stimulant properties can interfere with pentobarbital's ability to induce sleep.

Stimulant drugs and caffeine:
Stimulant medications increase the nervous system's quickness. Stimulant drugs might make you feel jittery and increase your heart rate by speeding up your nervous system. Caffeine may also have the effect of speeding up the neurological system. Caffeine combined with stimulant medicines can lead to significant complications such as an elevated heart rate and high blood pressure. Caffeine should not be used with stimulants.

Alcohol and caffeine:
To get rid of caffeine, the body breaks it down. The body's ability to break down caffeine is slowed by alcohol. Taking caffeine alongside alcohol may result in an excessive amount of caffeine in the bloodstream, as well as caffeine adverse effects such as jitteriness, headache, and rapid heartbeat.

Birth control pills and caffeine:
To get rid of caffeine, the body breaks it down. The rate at which caffeine is broken down in the body can be slowed by birth control pills. Caffeine can cause jitteriness, headaches, rapid heartbeat, and other negative effects when used with birth control tablets.

Fluconazole and caffeine:
To get rid of caffeine, the body breaks it down. Fluconazole (Diflucan) may slow down the body's caffeine elimination. Caffeine may linger in the bloodstream for longer when taken with fluconazole (Diflucan), increasing the risk of adverse effects such as agitation, anxiety, and insomnia.

Antidiabetes drugs and caffeine:
Caffeine has the potential to raise blood sugar levels. Blood sugar levels are controlled using diabetes medicines. When certain diabetes drugs are used with coffee, the effectiveness of the diabetes medications may be reduced. Keep a tight eye on your blood sugar levels. It's possible that the dose of your diabetes medication needs to be adjusted.

Mexiletine and caffeine:
To get rid of caffeine, the body breaks it down. Mexiletine (Mexitil) can slow down the breakdown of caffeine in the body. When Mexiletine (Mexitil) is used with caffeine, the effects and negative effects of caffeine may be amplified.

Terbinafine and caffeine:
To get rid of caffeine, the body breaks it down. Terbinafine (Lamisil) can slow down the body's caffeine elimination. Caffeine adverse effects such as jitteriness, headache, rapid heartbeat, and other symptoms might be exacerbated when used with terbinafine (Lamisil).

Contraindications

History of hypersensitivity to any of the components.

Mode of actions

Paracetamol acts as an analgesic by inhibiting the production of pain impulses in the peripheral nervous system. Antipyresis is caused by the inhibition of the hypothalamus heat-regulating region. Its ineffective anti-inflammatory properties are due to the suppression of prostaglandin production in the central nervous system.

Caffeine is a methylxanthine that inhibits phosphodiesterase. It binds to central adenosine receptors and blocks them. It's a stimulant for the central nervous system and the respiratory system. It has bronchodilating and diuretic qualities, and it makes muscular work easier.

Dosage & Administration

Adults :
1-2 tablets every 4-6 hours. Maximum dose: 8 tablets daily. Not recommended for children below 12 years.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

Pack Size & Price

200's pack Price : ৳380.38

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There are few similar medicines of Ace PLUS are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.

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