Precautions and warnings

Propranolol should be used carefully in people who have liver or kidney problems. It should not be used to treat sudden, severe high blood pressure.

Propranolol can lower the pressure inside the eye. People taking this medicine should be aware that it might affect the results of eye tests for glaucoma. Stopping propranolol suddenly can cause eye pressure to rise again.

Risk of Severe Allergic Reactions

Patients who have had serious allergic reactions in the past may react more strongly to allergens while taking beta-blockers like propranolol. Additionally, regular doses of epinephrine (used to treat allergic reactions) may not work as well for these patients.

Drug Interactions

Common drugs include antidiabetics, verapamil, diltiazem, lignocaine, ergotamine, dihydroergotamine, indomethacin, chlorpromazine, anesthetics, disopyramide, quinidine, amiodarone, digitalis glycosides, cimetidine, hydralazine, adrenaline, and alcohol.

Contraindications

Propranolol hydrochloride should not be used in the following situations:
1) cardiogenic shock;
2) very slow heart rate (sinus bradycardia) or heart block worse than first degree;
3) bronchial asthma;
4) congestive heart failure, **unless** the heart failure is caused by a fast abnormal heart rhythm that propranolol hydrochloride can treat.

Mode of actions

Propranolol is a type of beta-blocker that is not selective for specific receptors. It blocks both beta-1 and beta-2 receptors, which leads to a lower heart rate, decreased strength of heart contractions, reduced blood pressure, and less oxygen needed by the heart. Propranolol also helps stabilize the membranes of heart cells.

Dosage & Administration

Adults
Hypertension: As starting dose of 80mg twice a day may increased at weekly intervals according to response. The usual dose range is 160-320mg per day. With concurrentdiuretic or other antihypertensive drugs a further reduction of blood pressure is obtained.

Angina, anxiety,migraine and essential tremor:
A staring dose of 40mg two or three times daily may be increased by the same amount at weekly intervals according to patients’ response. An adequate response in anxiety, migraine and essential tremor is usually seen in the range 80-160mg/day and an angina in the range 120-240mg/day.

Situational and generalized anxiety:
A dose of 40mg daily may provide short term relief of acute situational anxiety.
Generalized anxiety require long term therapy, usually responds adequately to 40mg twice daily which, which individual cases, may be increased to 40mg three times daily. Treatment should be continued according to responses. Patients shouldreviewed after 6 to12 months treatment.

Dysarhythmias, anxiety tachycardia, hypertrophic obstructive cardiomyopathy and thyrotoxicosis:
A dosage range of 10-40mg three or four times a day usually achieves the required response.

Post myocardial infarction:Treatment should be started between days 5 and after 21 after myocardial infarction,with an initial dose of 40mg four times a day for 2 or 3 days. In order to improve compliance the total daily doses three after be given as 80mg twice a day.

Phaeochromocytoma (Used only with an alpha receptor blocking drug).
Pre-operative: 60mg daily for three days. Non-operable malignant cases: 30mg daily.

Children: Sysrhythmias, Phaeochromocytoma,Thyrotoxicisis: Dosage should be individually determined and the following is only a guide.0.25-0.5mg/kg three or four times daily as required.

Migraine Under 12 years: 20mg two or three times daily.
Over 12 years: The adult dose.

As Extended release Capsule:
Hypertension
Dosage Must Be Individualized. The usual initial dosage is 80 mg propranolol hydrochloride extended-release capsules once daily, whether used alone or added to a diuretic. The dosage may be increased to 120 mg once daily or higher until adequate blood pressure control is achieved. The usual maintenance dosage is 120 to 160 mg once daily. In some instances a dosage of 640 mg may be required. The time needed for full hypertensive response to a given dosage is variable and may range from a few days to several weeks.

Angina Pectoris

Dosage Must Be Individualized. Starting with 80 mg propranolol hydrochloride extended-release capsules once daily, dosage should be gradually increased at three- to seven-day intervals until optimal response is obtained. Although individual patients may respond at any dosage level, the average optimal dosage appears to be 160 mg once daily. In angina pectoris, the value and safety of dosage exceeding 320 mg per day have not been established.

If treatment is to be discontinued, reduce dosage gradually over a period of a few weeks.

Migraine
Dosage Must Be Individualized. The initial oral dose is 80 mg propranolol hydrochloride extended-release capsules once daily. The usual effective dose range is 160 to 240 mg once daily. The dosage may be increased gradually to achieve optimal migraine prophylaxis. If a satisfactory response is not obtained within four to six weeks after reaching the maximal dose, propranolol hydrochloride extended-release capsules therapy should be discontinued. It may be advisable to withdraw the drug gradually over a period of several weeks.

Hypertrophic Subaortic Stenosis
80 mg to 160 mg propranolol hydrochloride extended-release capsules once daily.

Pregnancy & Lactation

This medicine is not allowed during pregnancy. Do not use it if you are pregnant. It can be absorbed through the skin and lungs caused can damage your unborn child’s organs and cause congenital disabilities. Strict effective birth control during treatment and for six months after stopping this medicine. If you do become pregnant, stop taking this medicine and discuss your doctor right away.

There is no specific information on whether this medicine passes into breast milk or not. Considering the possible risks for the children, breastfeeding while using this medicine is not recommended and at least two weeks after the last dose. Consult your doctor before breastfeeding.

Pack Size & Price