Calcefer EFF (Tablet)
Manufactured by: Renata Limited
Calcium Carbonate + Calcium Lactate Gluconate + Vitamin-C + Vitamin D3 Similar medicine
Calcefer EFF is indicated for
- Osteoporosis
- Calcium deficiency
- Rickets
- Hypocalcaemia
- Calcium supplement
- Osteomalacia
Precautions and warnings
Patients with mild to severe renal failure or mild hypercalciuria need to be closely monitored. Patients with mild to moderate renal failure or mild hypercalciuria should have their plasma calcium levels and urinary calcium excretion checked on a regular basis. Urinary Calcium excretion should be assessed in patients with a history of renal stones to rule out hypercalciuria. Long-term treatment should be monitored for serum and urine calcium levels, as well as kidney function, and medication should be reduced or stopped if urinary calcium reaches 7.5 mmol/24 hours. Calcium and Vitamin-D supplements from other sources should be factored in.
Side-effects
- The use of Calcium supplements has rarely given rise to mild gastrointestinal disturbances
- such as constipation
- flatulence
- nausea
- gastric pain
- diarrhoea. Following administration of Vitamin-D supplements occasional skin rash has been reported. Hypercalciuria
- and in rare cases hypercalcaemia have been seen in long-term treatment with Vitamin-D at high doses.
Drug Interactions
Calcium carbonate: When used with thiazide diuretics or Vitamin D, milk-alkali syndrome and hypercalcemia might occur. Corticosteroids cause a decrease in absorption. Tetracyclines, atenolol, iron, quinolones, alendronate, Na fluoride, Zn, and calcium-channel blockers are all reduced in absorption. Enhances the effects of digitalis glycosides on the heart and may lead to digitalis intoxication.
Calcium Lactate: Calcium-channel blockers' efficacy may be reduced by this substance. Concurrent administration of IV calcium salt and cardiac glycosides can result in significant side effects. When used with thiazide diuretics, there is a higher risk of hypercalcemia. Tetracycline, alendronate, atenolol, iron, quinolone antibiotics, sodium fluoride, and zinc absorption may be reduced.
Calcium gluconate: When high calcium doses are combined with thiazide diuretics, milk-alkali syndrome and hypercalcemia can occur. Digoxin toxicity may be exacerbated. Calcium-channel blockers' effects are reduced. Calcitriol improves absorption (a Vitamin-D metabolite).
When used with thiazide diuretics, calcium, or phosphate, vitamin D3 increases the risk of hypercalcemia. Antiepileptic medications (such as carbamazepine, phenobarbitone, phenytoin, and primidone) can raise Vitamin D requirements. Vitamin-D efficacy may be reduced by antibiotics such as rifampicin and isoniazid. Vitamin D may be counteracted by corticosteroids. Any cardiac glycoside, such as digoxin. When combined with cholestyramine, colestipol, mineral oil, or orlistat, absorption is reduced. Ketoconazole.
Deferoxamine, hormone contraceptives, fluphenazine, warfarin, elemental iron, salicylates, warfarin, fluphenazine, disulfiram, mexiletine, Vitamin-B12.
Contraindications
Hypercalcemia caused by myeloma, bone metastases, or another malignant bone disease, sarcoidosis, primary hyperparathyroidism, and Vitamin-D overdosage are all absolute contraindications. It's also not recommended if you have severe renal failure or are allergic to any of the tablet's ingredients.
Mode of actions
Calcium carbonate/vitamin D3 helps to prevent or treat calcium deficiency. It also aids in the performance of nerves and muscles, as well as regular cardiac function. A cofactor in enzymatic processes that is required for neurotransmission, muscular contraction, and a variety of signal transduction pathways.
Normal metabolic operations, including hematopoiesis, require vitamins and minerals. Vitamin D3 is a sterol that is fat-soluble. It is required for the maintenance of calcium and phosphate homeostasis as well as bone mineralization. Vitamin D is also necessary for strong bones because it helps calcium absorption from the gastrointestinal tract.
Vitamin C is required for collagen formation and tissue repair, as well as other metabolic pathways such as the synthesis of catecholamines, carnitine, and steroids. It also plays a role in the conversion of folic acid to folinic acid.
Dosage & Administration
Dosage should be individualized based on the demands in age, sex and various physiological (pregnancy & lactation) & disease conditions. In general the dosage is-
Adults and children above 7 years: 1 effervescent tablet daily
Children 3-7 years: Half effervescent tablet daily
Pregnancy & Lactation
FDA has not yet classified this medicine into a specified pregnancy category. Although there is no enough evidence that taking this medicine during you are pregnant is harmful.
Discuss with your doctor if you are trying to get pregnant while taking this medicine too.
If you do become pregnant while you are taking this medicine, you should continue to take it and contact with your doctors as quickly as possible. They can assist you to decide whether or not to keep taking this medicine. If you abandon taking this medicine and become sick, this would be more pernicious to your child than staying on the medication.
There is no specific information about whether this medicine is passed on to the baby through breast milk. During this medication, if your baby becomes very sleepy, restless, fatigued, exhibit feeding problems, stop breastfeeding and talk to your doctors very quickly.
Pack Size & Price
10's pack Price : ৳60
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