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Locid 400mg (Tablet)

Manufactured by: ACI Limited

Aluminium Hydroxide Similar medicine

Locid is indicated for Heartburn, Indigestion, Gastric Hyperacidity, Peptic ulcer disease,

Precautions and warnings

Chronic renal impairment; CHF; oedema; cirrhosis and low Na diets; patients with recent GI haemorrhage. Administer 2-3 hrs before/after another medication to minimise drug interactions. Pregnancy and lactation.

Side-effects

Constipation; intestinal obstruction (with large doses); phosphate depletion may occur with prolonged admin or large doses.

Drug Interactions

Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.

Contraindications

Hypersensitivity to aluminium salts.

Mode of actions

Alumunium hydroxide acts on the HCl in the stomach by neutralization, forming aluminium chloride salt and water.

Dosage & Administration

Oral
Antacid
Adult: Up to 1 g daily.
Oral
Hyperphosphataemia in patients with chronic renal failure
Adult: Dose is adjusted to the individual patient's requirement. Up to 10 g/day may be given in divided doses with meals.
Max Dosage: 10 g daily in divided doses.

May be taken with or without food.

Pregnancy & Lactation

Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

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