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Gentosep (Cream)

Manufactured by: Beximco Pharmaceuticals Ltd.

Gentamicin 0.3% Topical Similar medicine

Gentosep is indicated for

  • Bacterial skin infections
  • Burns
  • eczema
  • seborrheic dermatitis
  • ecthyma
  • excoriation
  • folliculitis
  • furunculosis
  • insect bites
  • stings
  • lacerations
  • abrasions
  • paronychia
  • pyoderma gangrenosum
  • skin cysts
  • abscesses
  • stasis ulcers
  • infected skin ulcers
  • bacterial
  • fungal or viral superinfection
  • sycosis barbae
  • minor surgical wounds
  • infected contact dermatitis caused by susceptible organisms.

Precautions and warnings

Be careful when using gentamicin with other medicines that affect nerves and muscles, or in people with myasthenia gravis or Parkinson’s disease. Also, use caution in conditions that can increase the risk of ear or kidney damage, and in women who are breastfeeding. Check gentamicin blood levels in patients who are taking high doses, using it for a long time, or who are infants, elderly, have kidney problems, cystic fibrosis, or are significantly overweight. Regularly monitor hearing and kidney function during treatment.

Side-effects

  • Dizziness or vertigo; acute renal failure
  • interstitial nephritis
  • acute tubular necrosis; electrolyte imbalances; transient elevation of serum bilirubin
  • aminotransferases; purpura; nausea
  • vomiting; convulsions
  • mental depression
  • hallucinations. Atrophy or rat necrosis at inj sites. Potentially Fatal: Nephrotoxicity
  • ototoxicity
  • neuromuscular blockade (may unmask or aggravate myasthaenia gravis).

Drug Interactions

This medicine works better when used with ampicillin, benzylpenicillin, and other beta-lactam antibiotics. However, using it together with anesthetics or opioids increases the risk of dangerous breathing problems. It can also lower how quickly the body clears zalcitabine from the kidneys and may cause low calcium levels in the blood if used with bisphosphonates. Do not use this medicine with agalsidase alfa or beta because it can block the activity of beta-galactosidase.

**Serious Risks:**
The chance of severe ear damage (ototoxicity) is higher if this medicine is taken with ethacrynic acid or furosemide. Drugs like cephalosporins, ciclosporin, cisplatin, vancomycin, hydrocortisone, and indometacin can increase the risk of kidney damage (nephrotoxicity) when used together with it. This medicine can also make the effects of muscle relaxants (neuromuscular blocking agents) stronger.

Contraindications

Do not use if you have ever had an allergic reaction to aminoglycosides, if you are pregnant, or if you have liver problems.

Mode of actions

Gentamicin is a type of aminoglycoside antibiotic that attaches to the 30s and 50s ribosomal subunits in certain bacteria. This stops the bacteria from making proteins properly, which damages their cell membrane and helps kill them.

Dosage & Administration

Adult & Child: Apply to the affected area 3-4 times daily.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.

This medicine passes into breast milk. Talk to your doctor before breastfeeding.

Pack Size & Price

15gm tube Price : ৳18.45

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Click here to see more similar medicines

There are few similar medicines of Gentosep are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.