Aphrin PFS 125mg/5ml (Powder for Suspension)
Manufactured by: Apex Pharmaceuticals Ltd.
Cephradine Similar medicine
Aphrin PFS is indicated for
- Pneumonia
- Pharyngitis
- Susceptible infections
- Otitis media
- Skin
- Skin-Structure Infections
- Rheumatic fever
- Tonsillitis
- Respiratory tract infections
- Urinary tract infections
- Surgical Prophylaxis
- Genitourinary tract infections
- Acute prostatitis
Precautions and warnings
Patients with a history of penicillin sensitivity, renal impairment, pregnant women, and mothers who feed their babies breast milk should be given special attention.
Side-effects
- Diarrhoea
- nausea
- vomiting; leukopenia
- neutropenia
- eosinophilia
- rash
- pruritus; joint pain; increased BUN
- creatine; dizziness. Potentially Fatal: Pseudomembranous colitis.
Drug Interactions
Loop diuretics increase the risk of nephrotoxicity. Renal clearance is reduced when probenecid is used.
When nephrotoxic medications like aminoglycosides are taken with Cefradine, the risk of kidney damage increases. Renal toxicity was increased by diuretics such as frusemide, ethacrynic acid, and probenecid.
Contraindications
Porphyria and hypersensitivity to the active ingredient in cefradine or other cephalosporins.
Mode of actions
Cefradine is a first-generation cephalosporin that blocks the last transpeptidation step of peptidoglycan production in the bacterial cell wall by binding to one or more penicillin-binding proteins (PBPs), halting cell wall synthesis and causing bacterial cell death.
Dosage & Administration
Adult: PO Susceptible infections 1-2 g/day in 2-4 divided doses. Max: 4 g/day.
IV/IM Severe infections 2-4 g/day in divided doses. Max: 8 g/day.
Surgical prophylaxis 1-2 g pre-op. Subsequent doses may be given as needed.
Skin and skin structures and respiratory tract infection: Usual dose is 250 mg every 6 hours or 500 mg every 12 hours.
Lobar pneumonia: 500 mg every 6 hours or 1 gm every 12 hours.
Urinary tract infection: Usual dose is 500 mg every 12 hours.
Gastro-intestinal tract infection: 500 mg three to four times daily.
Children: Oral: The usual total dose is 25 to 50 mg/kg/day given in 2 to 4 equally divided doses.
Injection: 50 to 100 mg/kg/day in 4 equally divided doses. The usual total dose may be increased up to 200-300 mg/kg/day.
Perioperative prophylaxis: Recommended dose is 1-2 gm by intramuscular or intravenous route; subsequent parenteral or oral doses are given as appropriate.
Renal impairment: For patients undergoing chronic intermittent haemodialysis: 250 mg may be given at the start of the session, repeated after 6-12 hr, then again 36-48 hr after the initial dose, and again at the start of the next haemodialysis if >30 hr have elapsed since the previous dose.
CrCl (ml/min)
>20 500 mg every 6 hr.
5-20 250 mg every 6 hr.
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.
Discuss with your doctors and tell them feedback about this medicine.
There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.
Pack Size & Price
100ml bot Price : ৳80
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