Cispenam 500 IV (Injection)
Manufactured by: Incepta Pharmaceuticals Ltd.
Cilastatin + Imipenem Similar medicine
Cispenam 500 IV is indicated for
- Fibrosis kistik
- Septikemia bakterial
- Endokarditis
- Infeksi rentan
- Infeksi Saluran Pernapasan Bawah
- Gonore
- Infeksi kulit dan struktur kulit
- Infeksi saluran kemih
- Infeksi Tulang dan Sendi
- Profilaksis Bedah
Precautions and warnings
Berhati-hatilah saat memberikan obat ini kepada pasien yang alergi terhadap antibiotik beta-laktam lainnya, karena mereka mungkin juga bereaksi terhadap obat ini. Gunakan dengan hati-hati pada orang dengan kondisi seperti epilepsi atau masalah pada ginjal atau hati. Berhati-hatilah jika pasien sedang hamil atau menyusui.
Side-effects
- Ruam kulit
- urtikaria
- eosinofilia
- demam
- mual
- muntah
- diare
- perubahan warna gigi atau lidah
- dan perubahan rasa. Eritema multiforme
- dermatitis eksfoliatif. Nyeri dan tromboflebitis dapat terjadi di tempat suntikan. Berpotensi Fatal: Sindrom Stevens-Johnson
- nekrolisis epidermal toksik.
Drug Interactions
Mengonsumsi probenesid bersamaan dengan cilastatin dapat membuat cilastatin bertahan lebih lama di dalam tubuh. Menggunakan cilastatin bersama dengan gansiklovir dapat meningkatkan risiko kejang.
Mode of actions
Imipenem adalah antibiotik kuat yang membunuh banyak jenis bakteri dengan menghentikan pembentukan dinding selnya. Ia bekerja dengan baik karena tidak dipecah oleh enzim tertentu (disebut ?-laktamase) yang digunakan banyak bakteri untuk melindungi diri mereka sendiri. Cilastatin adalah obat yang menghambat enzim di ginjal (disebut dehydropeptidase I). Ketika imipenem diberikan bersama dengan cilastatin, ini membantu mencegah penguraian imipenem di ginjal dan melindungi dari kerusakan ginjal. Kedua obat tersebut diberikan dalam bentuk garam natrium.
Dosage & Administration
Dewasa: IV Rentan terhadap infeksi Sebagai imipenem: 1-2 g/hari dalam dosis terbagi setiap 6-8 jam. Profilaksis bedah Sebagai imipenem: 1 g pada induksi anestesi, diikuti 1 g 3 jam kemudian. Dosis tambahan 500 mg dapat diberikan pada 8 dan 16 jam setelah induksi jika diperlukan.
Anak: >40 kg: sama dengan dosis dewasa. >3 bulan dan
Pregnancy & Lactation
Meskipun penelitian pada reproduksi hewan menunjukkan efek buruk pada janin dan belum ada penelitian yang memadai dan terkontrol dengan baik pada wanita hamil, namun selama kehamilan, obat ini dapat digunakan tepat ketika benar-benar diperlukan meskipun ada potensi risikonya.
Ibu dengan bayi baru lahir yang telah menggunakan obat ini selama 3 bulan terakhir kehamilan mungkin jarang mengalami gejala termasuk mengantuk, otot kaku atau gemetar, kesulitan makan atau bernapas, dan menangis terus-menerus. Jika Anda melihat gejala-gejala ini pada bayi Anda terutama pada bulan pertama, segera beri tahu dokter.
Obat ini masuk ke dalam ASI. Bicaralah dengan dokter Anda sebelum menyusui.
Pack Size & Price
500mg vial X 1's pack Price : ৳1195
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