Amimax 100mg/2ml (Injection)
Manufactured by: Bio Pharma Laboratories Ltd.
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Amimax is indicated for
- Tuberkulosis
- Infeksi saluran kemih yang rumit dan berulang
- Infeksi Gram-negatif yang parah
- Infeksi mikobakteri non-tuberkulosis
- Septikemia bakterial
- Infeksi saluran pernafasan
- Tulang dan sendi
- Sistem saraf pusat serta kulit dan jaringan lunak
- Infeksi intra-abdomen
- Luka bakar
- Infeksi pasca operasi
- Meningitis
- Peritonitis
- Sepsis neonatal
Precautions and warnings
Vertigo dan tinitus merupakan gejala gagal ginjal. Jika Anda melihat tanda-tanda ototoksisitas, neurotoksisitas, atau hipersensitivitas, hentikan penggunaan; jika Anda sedang menyusui, hentikan penggunaannya. Masa pengobatan dangt;14 hari belum terbukti aman. Sebelum dan selama terapi, perhatikan fungsi ginjal Anda.
Side-effects
- Tinitus
- vertigo; ataksia dan tuli yang nyata. Berpotensi Fatal: Ototoksisitas
- nefrotoksisitas
- blokade neuromuskular.
Drug Interactions
Jika dikonsumsi bersamaan, amfoterisin B dapat menyebabkan nefrotoksisitas dan membatasi pembersihan amikasin.
Mungkin mematikan: Obat-obatan nefrotoksik atau ototoksik lainnya mempunyai efek ototoksik atau nefrotoksik yang meningkat. Obat penghambat neuromuskular memperbaiki blokade neuromuskular. Diuretik yang kuat meningkatkan risiko ototoksisitas.
Contraindications
Kehamilan, gendang telinga berlubang, miastenia gravis, hipersensitivitas.
Mode of actions
Amikasin berikatan dengan subunit ribosom 30S dari bakteri yang rentan, sehingga menghambat sintesis proteinnya.
Dosage & Administration
parenteral
Infeksi saluran kemih tanpa komplikasi
Dewasa: 250 mg dua kali sehari, diberikan melalui suntikan IM, IV selama 2-3 menit atau sebagai infus IV.
Infeksi Gram-negatif berat yang resisten terhadap gentamisin dan tobramisin
Dewasa: 15 mg/kg setiap hari dalam dosis terbagi sama, disuntikkan setiap 8 atau 12 jam selama 7-10 hari. Maks: Hingga 500 mg setiap 8 jam pada infeksi yang mengancam jiwa. Dosis kumulatif maks: 15 g. Dosis dapat diberikan melalui IM, injeksi IV lambat selama 2-3 menit atau infus IV.
Anak: 15 mg/kg setiap hari dalam dosis terbagi sama, disuntikkan setiap 8 atau 12 jam selama 7-10 hari. Neonatus: 10 mg/kg setiap hari dalam 2 dosis terbagi.
Gangguan fungsi ginjal: Pada pasien dengan gangguan fungsi ginjal, dosis harian harus dikurangi dan/atau interval antar dosis ditingkatkan untuk menghindari akumulasi obat. Jadwal dosis sederhana untuk gangguan ginjal diberikan di bawah ini:
Jadwal dosis fungsi ginjal
Gangguan ringan 500 mg setiap 18 jam
Gangguan sedang 500 mg tiap 24 jam
Gangguan berat 250 mg tiap 24 jam.
Pregnancy & Lactation
Obat ini tidak diperbolehkan selama kehamilan. Jangan gunakan jika Anda sedang hamil. Dapat diserap melalui kulit dan paru-paru sehingga dapat merusak organ tubuh anak Anda yang belum lahir dan menyebabkan cacat bawaan. Alat kontrasepsi yang efektif dan ketat selama pengobatan dan selama enam bulan setelah menghentikan obat ini. Jika Anda hamil, hentikan penggunaan obat ini dan segera diskusikan dengan dokter Anda.
Belum ada informasi spesifik apakah obat ini masuk ke dalam ASI atau tidak. Mengingat kemungkinan risiko pada anak-anak, menyusui saat menggunakan obat ini tidak dianjurkan dan setidaknya dua minggu setelah dosis terakhir. Konsultasikan dengan dokter Anda sebelum menyusui.
Pack Size & Price
10 amps pack Price : ৳160
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