Aminophylline 100mg (Tablet)
Manufactured by: Ambee Pharmaceuticals Ltd.
Aminophylline Similar medicine
Aminophylline is indicated for
- Asthma
- Acute bronchospasm
- Chronic bronchitis
- Emphysema
- COPD
Precautions and warnings
Neonatals, the elderly, lactation, pregnancy, cardiac/hepatic disorders, peptic ulcers, hyperthyroidism, hypertension, epilepsy, heart failure, chronic alcoholism, acute febrile sickness, chronic alcoholism.
Side-effects
- Nausea
- vomiting
- abdominal pain
- diarrhoea
- headache
- insomnia
- dizziness
- anxiety
- restlessness; tremor
- palpitations. Potentially Fatal: Convulsions
- cardiac arrhythmias
- hypotension
- sudden death after too rapid IV injection.
Drug Interactions
Xanthines that aren't xanthines. Antiarrhythmics, cimetidine, disulfiram, fluvoxamine, interferon, macrolide antibiotics, quinolones, oral contraceptives, thiabendazole, and viloxazine all reduce clearance. Phenytoin, anticonvulsants, ritonavir, rifampicin, sulfinpyrazone, and cigarette smoking all accelerate clearance. 2-agonists, corticosteroids, and diuretics.
Possibly lethal: With sympathomimetics and halothane, the risk of cardiac arrhythmias is increased. Pancuronium causes tachycardia. Metabolism is slowed by?-blockers. Quinolones and ketamine both increase the likelihood of convulsions.
Contraindications
Hypersensitivity.
Mode of actions
Theophylline and ethylenediamine are combined to form aminophylline. Theophylline's solubility in water is increased by ethylenediamine, which is inactive. Bronchial smooth muscle is relaxed by theophylline. Increased intracellular cAMP due to phosphodiesterase inhibition, adenosine receptor antagonism, prostaglandin antagonism, and effects on intracellular calcium are all suggested explanations.
Dosage & Administration
Oral
Chronic bronchospasm
Adult: As hydrate: Initially, 225-450 mg bid, increased if necessary.
Child: >3 yr: As modified-release hydrate: 12 mg/kg daily increased to 24 mg/kg daily in 2 divided doses after 1 wk.
Intravenous
Acute severe bronchospasm
Adult: Loading dose: 5 mg/kg (ideal body weight) or 250-500 mg (25 mg/ml) by slow inj or infusion over 20-30 min. Maintenance infusion dose: 0.5 mg/kg/hr. Max rate: 25 mg/min.
Child: Loading dose: same as adult dose. Maintenance dose: 6 mth-9 yr: 1 mg/kg/hr and 10-16 yr: 0.8 mg/kg/hr.
Elderly: Dose reduction may be ncessary.
Hepatic impairment: Dose reduction may be ncessary.
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.
Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.
This medicine passes into breast milk. Talk to your doctor before breastfeeding.
Pack Size & Price
500's pack Price : ৳190
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There are few similar medicines of Aminophylline are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.
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