Iropen IV/IM (Injection)
Manufactured by: Renata Limited
Cilastatin + Imipenem Similar medicine
Iropen IV/IM is indicated for
- Mukoviszidose
- bakterielle Septikämie
- Endokarditis
- anfällige Infektionen
- Infektionen der unteren Atemwege
- Gonorrhoe
- Infektionen der Haut und der Hautstruktur
- Harnwegsinfektionen
- Knochen- und Gelenkinfektionen
- chirurgische Prophylaxe
Precautions and warnings
Seien Sie vorsichtig, wenn Sie dieses Arzneimittel Patienten verabreichen, die gegen andere Beta-Lactam-Antibiotika allergisch sind, da diese möglicherweise auch auf dieses Arzneimittel reagieren. Bei Menschen mit Erkrankungen wie Epilepsie oder Nieren- oder Leberproblemen mit Vorsicht anwenden. Seien Sie besonders vorsichtig, wenn die Patientin schwanger ist oder stillt.
Side-effects
- Hautausschläge
- Urtikaria
- Eosinophilie
- Fieber
- Übelkeit
- Erbrechen
- Durchfall
- Zahn- oder Zungenverfärbung und Geschmacksveränderung. Erythema multiforme
- exfoliative Dermatitis. An der Injektionsstelle können Schmerzen und Thrombophlebitis auftreten. Potenziell tödlich: Stevens-Johnson-Syndrom
- toxische epidermale Nekrolyse.
Drug Interactions
Die gleichzeitige Einnahme von Probenecid und Cilastatin kann dazu führen, dass Cilastatin länger im Körper verbleibt. Die Anwendung von Cilastatin zusammen mit Ganciclovir kann das Risiko von Anfällen erhöhen.
Mode of actions
Imipenem ist ein starkes Antibiotikum, das viele Arten von Bakterien abtötet, indem es sie am Aufbau ihrer Zellwände hindert. Es funktioniert gut, weil es nicht durch bestimmte Enzyme (sogenannte ?-Lactamasen) abgebaut wird, die viele Bakterien zu ihrem Schutz nutzen. Cilastatin ist ein Arzneimittel, das ein Enzym in den Nieren (Dehydropeptidase I) blockiert. Wenn Imipenem zusammen mit Cilastatin verabreicht wird, verhindert es den Abbau von Imipenem in den Nieren und schützt vor Nierenschäden. Beide Medikamente werden als Natriumsalze verabreicht.
Dosage & Administration
Erwachsener: IV. Anfällige Infektionen Als Imipenem: 1–2 g/Tag in aufgeteilten Dosen 6–8 Stunden. Chirurgische Prophylaxe Als Imipenem: 1 g bei Narkoseeinleitung, gefolgt von 1 g 3 Stunden später. Bei Bedarf können 8 und 16 Stunden nach der Einleitung zusätzliche Dosen von 500 mg verabreicht werden.
Kinder: >40 kg: gleiche Dosis wie für Erwachsene. >3 Monate und
Pregnancy & Lactation
Obwohl Reproduktionsstudien an Tieren eine nachteilige Wirkung auf den Fötus gezeigt haben und es keine ausreichenden und gut kontrollierten Studien bei schwangeren Frauen gibt, kann dieses Arzneimittel trotz möglicher Risiken während der Schwangerschaft nur dann angewendet werden, wenn dies unbedingt erforderlich ist.
Bei Müttern eines Neugeborenen, die dieses Arzneimittel in den letzten drei Monaten der Schwangerschaft eingenommen haben, kann es selten zu Symptomen wie Schläfrigkeit, Muskelsteifheit oder Zittern, Schwierigkeiten beim Füttern oder Atmen und ständigem Weinen kommen. Wenn Sie eines dieser Symptome bei Ihrem Baby bemerken, insbesondere im ersten Monat, informieren Sie sofort den Arzt.
Dieses Arzneimittel geht in die Muttermilch über. Sprechen Sie vor dem Stillen mit Ihrem Arzt.
Pack Size & Price
500mg vial X 1's pack Price : ৳1195
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