Iropen IV/IM (Injection)
Manufactured by: Renata Limited
Cilastatin + Imipenem Similar medicine
Iropen IV/IM is indicated for
- Муковисцидоз
- Бактериальная септицемия
- Эндокардит
- Восприимчивые инфекции
- Инфекции нижних дыхательных путей
- Гонорея
- Инфекции кожи и структур кожи
- Инфекции мочевыводящих путей
- Инфекции костей и суставов
- Хирургическая профилактика
Precautions and warnings
Будьте осторожны при назначении этого лекарства пациентам с аллергией на другие бета-лактамные антибиотики, поскольку они также могут реагировать на этот препарат. Используйте с осторожностью у людей с такими заболеваниями, как эпилепсия или проблемы с почками или печенью. Будьте особенно осторожны, если пациентка беременна или кормит грудью.
Side-effects
- Кожная сыпь
- крапивница
- эозинофилия
- лихорадка
- тошнота
- рвота
- диарея
- изменение цвета зубов или языка и изменение вкуса. Мультиформная эритема
- эксфолиативный дерматит. В месте инъекции могут возникнуть боль и тромбофлебит. Потенциально смертельно: синдром Стивенса-Джонсона
- токсический эпидермальный некролиз.
Drug Interactions
Прием пробенецида одновременно с циластатином может продлить пребывание циластатина в организме. Использование циластатина вместе с ганцикловиром может повысить риск возникновения судорог.
Mode of actions
Имипенем — сильный антибиотик, который убивает многие виды бактерий, не давая им строить клеточные стенки. Он работает хорошо, потому что не расщепляется определенными ферментами (называемыми β-лактамазами), которые многие бактерии используют для защиты. Циластатин – это лекарство, которое блокирует фермент в почках (так называемый дегидропептидаза I). Когда имипенем назначается вместе с циластатином, это помогает предотвратить расщепление имипенема в почках и защищает от повреждения почек. Оба препарата назначаются в виде натриевых солей.
Dosage & Administration
Взрослые: внутривенно. Восприимчивые инфекции. Как имипенем: 1–2 г/день в несколько приемов каждые 6–8 часов. Хирургическая профилактика. Как имипенем: 1 г при вводном наркозе, затем 1 г через 3 часа. При необходимости дополнительные дозы 500 мг могут вводиться через 8 и 16 часов после индукции.
Дети: >40 кг: доза такая же, как для взрослых. >3 мес. и
Pregnancy & Lactation
Хотя исследования репродукции на животных показали неблагоприятное влияние на плод, а адекватных и хорошо контролируемых исследований у беременных женщин не проводилось, во время беременности это лекарство можно применять только в случае крайней необходимости, несмотря на потенциальные риски.
У матерей новорожденного ребенка, принимавших этот препарат в течение последних 3 месяцев беременности, в редких случаях могут возникнуть такие симптомы, как сонливость, ригидность мышц или дрожь, проблемы с кормлением или дыханием, постоянный плач. Если вы заметили какой-либо из этих симптомов у вашего ребенка, особенно в первый месяц его жизни, немедленно сообщите об этом врачу.
Это лекарство проникает в грудное молоко. Поговорите со своим врачом перед кормлением грудью.
Pack Size & Price
500mg vial X 1's pack Price : ৳1195
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