Precautions and warnings

Make sure to treat low blood volume before starting this medication. Patients with atrial fibrillation may have a higher risk of developing a fast heart rate. There isn’t enough information to know if dobutamine is safe or effective after a recent heart attack. Use caution with elderly patients, newborns, and during pregnancy.

Drug Interactions

When used together with nitroprusside, dobutamine increases the amount of blood the heart pumps. Its blood pressure-raising effects are stronger if given with bretylium, guanethidine, certain drugs used during childbirth (oxytocic drugs), or tricyclic antidepressants (TCAs).

Contraindications

Hypersensitivity; idiopathic hypertrophic subaortic stenosis (IHSS).

Mode of actions

Dobutamine works by stimulating beta-adrenergic receptors in the heart, which increases both the strength of heart contractions and the heart rate.

Dosage & Administration

Adult: IV Acute heart failure 2.5-10 mcg/kg, up to 0.5-40 mcg/kg according to response.

Cardiac stress test As 1 mg/mL soln: 5 mcg/kg/min for 8 mins, increase dose at 5 mcg/kg/min until 20 mcg/kg/min, w/ each dose being infused for 8 mins before the next increase.

Because of its short half-life, Dobutamine Hydrochloride must be administered as a continuous intravenous infusion. Following the initiation of a constant rate infusion, or upon changing the rate, a steady-state dobutamine plasma concentration is achieved within approximately 10 minutes. Thus, loading doses or bolus injections are not necessary and are not recommended.

Recommended Dosage The rate of infusion needed to increase cardiac output has ranged from 2.5 to 10 mcg/kg/min in the majority of patients. Frequently, doses up to 20 mcg/kg/min are required for adequate haemodynamic improvement.

The rate of administration and the duration of therapy should be adjusted according to the patient's response, The indicators are: haemodynamic parameters such as heart rate and rhythm, arterial pressure, and, whenever possible, cardiac output and measurements of ventricular filling pressures and signs of pulmonary congestion.

Concentrations up to 5,000 mg/L have been administered to humans. The final volume administered should be determined by the fluid requirements of the patient. Rather than abruptly discontinuing therapy with Dobutamine Hydrochloride, it is often advisable to decrease the dosage gradually. Rates of Infusion Based on Concentration of Dobutamine Hydrochloride The rates of fluid infusion that are required to deliver specific dosages are a function of the concentration of Dobutamine Hydrochloride in the infusate.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.

Discuss with your doctors and tell them feedback about this medicine.

There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.

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