Gentin HC (Eye Drops)
Manufactured by: Opso Saline Ltd.
Gentamicin 0.3% + Hydrocortisone Acetate 1% Eye prep Similar medicine
Gentin HC is indicated for
- Infeksi yang rentan
- Keratitis
- Konjungtivitis alergi
- Blepharitis
- Kondisi alergi dan peradangan pada mata
- Konjungtivitis kronis
- Penyakit selesema musim semi
Precautions and warnings
Berhati-hatilah saat menggunakan gentamisin bersamaan dengan obat penghambat neuromuskular atau pada penderita miastenia gravis, penyakit Parkinson, atau mereka yang berisiko mengalami kerusakan telinga dan ginjal. Hindari selama menyusui. Periksa kadar gentamisin dalam darah untuk pasien yang menjalani pengobatan dosis tinggi atau jangka panjang—terutama bayi, orang lanjut usia, pasien dengan masalah ginjal, fibrosis kistik, atau obesitas berat. Pantau fungsi pendengaran dan ginjal secara teratur selama perawatan.
Side-effects
- Pusing atau vertigo; gagal ginjal akut
- nefritis interstisial
- nekrosis tubular akut; ketidakseimbangan elektrolit; peningkatan sementara bilirubin serum dan aminotransferase; purpura; mual
- muntah; kejang
- depresi mental
- halusinasi. Atrofi atau nekrosis tikus pada tempat suntikan. Berpotensi Fatal: Nefrotoksisitas
- ototoksisitas
- dan blokade neuromuskular (dapat mengungkap atau memperburuk miastenia gravis).
Drug Interactions
**Gentamisin:**
Mengonsumsi gentamisin dengan obat lain yang dapat membahayakan saraf atau ginjal – seperti sefalosporin, methisilin, amfoterisin B, ciclosporin, cisplatin, diuretik kuat (seperti asam ethacrynic atau furosemid), atau pelemas otot (misalnya, suksinilkolin, tubocurarine) – dapat meningkatkan risiko efek samping. Gentamisin dapat membuat pengencer darah (misalnya warfarin, fenindione) bekerja lebih kuat. Hal ini dapat mengurangi efek obat-obatan seperti neostigmin dan piridostigmin. Risiko kalsium darah rendah lebih tinggi jika dikonsumsi dengan bifosfonat, dan kemungkinan kelemahan otot meningkat jika dikonsumsi dengan toksin botulinum. Pada bayi baru lahir, indometasin dapat menyebabkan kadar gentamisin yang lebih tinggi dalam darah.
**Hidrokortison:**
Diuretik tiazid dapat memperburuk gula darah tinggi dan rendahnya kalium darah yang disebabkan oleh hidrokortison. Mengonsumsi obat antiinflamasi nonsteroid (NSAID) secara bersamaan meningkatkan risiko sakit maag atau pendarahan. Hidrokortison dapat mengubah cara kerja antikoagulan, dan orang mungkin perlu meningkatkan dosis obat diabetes atau tekanan darah. Ini mengurangi kadar salisilat dan obat antimuskarinik dalam darah, dan minum alkohol dapat memperburuk iritasi lambung. Obat-obatan seperti karbamazepin, fenitoin, primidon, barbiturat, dan rifampisin dapat mengurangi kinerja hidrokortison. Ketika diminum dengan siklosporin, kedua obat tersebut saling meningkatkan kadarnya dalam darah. Hidrokortison mungkin bekerja lebih kuat pada wanita yang mengonsumsi estrogen atau pil KB.
Contraindications
Jangan gunakan jika Anda memiliki riwayat reaksi alergi terhadap aminoglikosida, sedang hamil, atau memiliki masalah hati.
Mode of actions
Gentamisin merupakan antibiotik aminoglikosida yang bekerja dengan cara menempel pada bagian ribosom bakteri yang berusia 30-an dan 50-an. Hal ini menghalangi bakteri membuat protein yang mereka butuhkan, sehingga merusak membran sel dan akhirnya membunuh mereka.
Hidrokortison adalah obat kortikosteroid yang digunakan karena mengurangi peradangan dan menekan sistem kekebalan tubuh. Hal ini dilakukan dengan mencegah sel darah putih tertentu berpindah ke area yang meradang dan dengan mengurangi kebocoran pembuluh darah. Hidrokortison juga dapat digunakan untuk menggantikan hormon pada orang yang tidak menghasilkan cukup hormon, seperti pada orang dengan insufisiensi adrenokortikal.
Dosage & Administration
Oftal Infeksi oftalmik superfisial Dalam larutan 0,3%: Teteskan 1-2 tetes setiap 4 jam, hingga 2 tetes setiap jam pada kasus yang parah.
Pregnancy & Lactation
Meskipun penelitian pada reproduksi hewan menunjukkan efek buruk pada janin dan belum ada penelitian yang memadai dan terkontrol dengan baik pada wanita hamil, namun selama kehamilan, obat ini dapat digunakan tepat ketika benar-benar diperlukan meskipun ada potensi risikonya.
Ibu dengan bayi baru lahir yang telah menggunakan obat ini selama 3 bulan terakhir kehamilan mungkin jarang mengalami gejala termasuk mengantuk, otot kaku atau gemetar, kesulitan makan atau bernapas, dan menangis terus-menerus. Jika Anda melihat gejala-gejala ini pada bayi Anda terutama pada bulan pertama, segera beri tahu dokter.
Obat ini masuk ke dalam ASI. Bicaralah dengan dokter Anda sebelum menyusui.
Pack Size & Price
5 ml drop Price : ৳55.21
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