Psudonil 500mg/2ml (Injection)
Manufactured by: Drug International Ltd.
Amikacin Similar medicine
Psudonil is indicated for
- Tuberculose
- Infections urinaires compliquées et récurrentes
- Infections graves à Gram négatif
- Infections mycobactériennes non tuberculeuses
- Septicémie bactérienne
- Infections des voies respiratoires
- Os et articulations
- Système nerveux central et peau et tissus mous
- Infections intra-abdominales
- Brûlures
- Infections postopératoires
- Méningite
- Péritonite
- Sepsis néonatal
Precautions and warnings
Les vertiges et les acouphènes sont des symptômes d'insuffisance rénale. Si vous constatez des signes d'ototoxicité, de neurotoxicité ou d'hypersensibilité, arrêtez de le prendre ; si vous allaitez, arrêtez de l'utiliser. La période de traitement d'environ 14 jours ne s'est pas avérée sûre. Avant et pendant le traitement, surveillez votre fonction rénale.
Side-effects
- Acouphènes
- vertiges ; ataxie et surdité manifeste. Potentiellement mortel : ototoxicité
- néphrotoxicité
- blocage neuromusculaire.
Drug Interactions
Lorsqu'elle est prise simultanément, l'amphotéricine B peut provoquer une néphrotoxicité et limiter la clairance de l'amikacine.
Peut-être mortel : d'autres médicaments néphrotoxiques ou ototoxiques ont des effets ototoxiques ou néphrotoxiques accrus. Les médicaments de blocage neuromusculaire améliorent le blocage neuromusculaire. Les diurétiques puissants augmentent le risque d'ototoxicité.
Contraindications
Grossesse, perforation du tympan, myasthénie grave, hypersensibilité.
Mode of actions
L'amikacine se lie aux sous-unités ribosomales 30S des bactéries sensibles, inhibant ainsi la synthèse protéique.
Dosage & Administration
Parentéral
Infections urinaires non compliquées
Adulte : 250 mg bid, administrés par voie IM, IV inj pendant 2-3 minutes ou en perfusion IV.
Infections Gram-négatives sévères résistantes à la gentamicine et à la tobramycine
Adulte : 15 mg/kg par jour en doses égales, injectées toutes les 8 ou 12 heures pendant 7 à 10 jours. Max : jusqu'à 500 mg toutes les 8 heures en cas d'infections potentiellement mortelles. Dose cumulée maximale : 15 g. Les doses peuvent être administrées par voie IM, par injection IV lente sur 2 à 3 minutes ou par perfusion IV.
Enfant : 15 mg/kg par jour en doses égales, injectées toutes les 8 ou 12 heures pendant 7 à 10 jours. Nouveau-nés : 10 mg/kg par jour à diviser en 2 prises.
Insuffisance rénale : chez les patients présentant une insuffisance rénale, la dose quotidienne doit être réduite et/ou les intervalles entre les doses augmentés pour éviter l'accumulation du médicament. Le schéma posologique simple pour l’insuffisance rénale est présenté ci-dessous :
Fonction rénale Schéma posologique
Légère déficience 500 mg toutes les 18 heures
Incapacité modérée 500 mg toutes les 24 heures
Insuffisance sévère 250 mg toutes les 24 heures.
Pregnancy & Lactation
Ce médicament est interdit pendant la grossesse. Ne l'utilisez pas si vous êtes enceinte. Il peut être absorbé par la peau et les poumons, ce qui peut endommager les organes de votre enfant à naître et provoquer des handicaps congénitaux. Contrôle des naissances strict et efficace pendant le traitement et pendant six mois après l'arrêt de ce médicament. Si vous tombez enceinte, arrêtez de prendre ce médicament et parlez-en immédiatement à votre médecin.
Il n'existe aucune information spécifique indiquant si ce médicament passe ou non dans le lait maternel. Compte tenu des risques possibles pour les enfants, l'allaitement pendant l'utilisation de ce médicament est déconseillé et ce au moins deux semaines après la dernière dose. Consultez votre médecin avant d'allaiter.
Pack Size & Price
5 amps pack Price : ৳225
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