Quinolex 80mg/5ml (Syrup)
Manufactured by: Globe Pharmaceuticals Ltd.
Chloroquine Phosphate Similar medicine
Quinolex is indicated for
- Artrite reumatóide
- Malária
- Lúpus eritematoso sistêmico
- LES
- Amebíase
Precautions and warnings
Não use este medicamento em pessoas com psoríase, doenças do sangue ou do sistema nervoso, miastenia gravis, problemas hepáticos ou renais, deficiência de G6PD, epilepsia ou em crianças. Também deve ser evitado durante a gravidez e amamentação. Ao administrar este medicamento por via intravenosa, faça a infusão lentamente para reduzir o risco de problemas cardíacos.
Side-effects
- Retinopatia
- queda de cabelo
- fotossensibilidade
- zumbido
- miopatia (terapia de longo prazo). Psicose
- convulsões
- leucopenia e raramente anemia aplástica
- hepatite
- distúrbios gastrointestinais
- tonturas
- hipocalemia
- dor de cabeça
- prurido
- urticária
- dificuldade de acomodação visual. Potencialmente Fatal: Parada cardíaca e respiratória
- colapso CV
- convulsões
- coma.
Drug Interactions
Tomar fenilbutazona ao mesmo tempo pode aumentar a probabilidade de você ter erupções cutâneas, reduzir o funcionamento da neostigmina e da piridostigmina e diminuir a quantidade de ampicilina que seu corpo absorve. A cimetidina pode aumentar a quantidade de cloroquina no sangue, retardando sua degradação.
**Riscos Sérios:**
- Quando a cloroquina é tomada com halofantrina ou outros medicamentos que afetam o ritmo cardíaco (como a amiodarona), há uma maior probabilidade de arritmias cardíacas perigosas.
- Também existe um risco maior de convulsões quando a cloroquina é tomada com mefloquina.
- Os antiácidos podem diminuir a absorção da cloroquina, por isso devem ser tomados com pelo menos 4 horas de intervalo um do outro.
- Raramente, pode ocorrer uma reação cutânea grave (síndrome de Stevens-Johnson) se a cloroquina for tomada com pirimetamina ou sulfadoxina.
- Tomar quinacrina com cloroquina pode aumentar o risco de efeitos colaterais.
Contraindications
Não use se você tiver alergia ao medicamento, infecção resistente possível ou confirmada por P. falciparum, porfiria, problemas de retina ou se estiver tomando outros medicamentos prejudiciais ao fígado.
Mode of actions
A cloroquina é usada para prevenir a malária e para tratar ataques repentinos de malária. Funciona bem contra os estágios sanguíneos de *Plasmodium vivax*, *P. malariae* e *P. falciparum*. A droga aumenta o pH dentro do vacúolo alimentar do parasita, o que interrompe a digestão da hemoglobina e afeta a forma como o parasita produz proteínas. A cloroquina também é útil no tratamento da amebíase fora do intestino. Para a artrite reumatóide (AR), tanto a cloroquina quanto o medicamento similar hidroxicloroquina podem ajudar a retardar o progresso da doença – sendo a hidroxicloroquina mais eficaz.
Dosage & Administration
Adulto: PO Malária aguda Como base: Inicial: 600 mg, depois 300 mg 6-8 horas mais tarde no dia 1. Continuar com 300 mg/dia nos dias 2 e 3.
Profilaxia da malária Como base: 300 mg/semana, começando 1 semana antes da exposição, continuando semanalmente e por pelo menos 4 semanas após a exposição.
Discóide e LES; Artrite reumatoide Como base: Inicial: 150 mg/dia. Máx.: 2,5 mg/kg/dia.
Amebíase hepática Como base: Com emetina ou desidroemetina: 600 mg/dia por 2 dias e depois 300 mg/dia por 2-3 semanas.
IV Malária grave Como base: 25 mg/kg administrados em várias infusões durante 30-32 horas.
Pregnancy & Lactation
Embora estudos de reprodução animal tenham demonstrado um efeito adverso no feto e não existam estudos adequados e bem controlados em mulheres grávidas, mas durante a gravidez, este medicamento pode ser utilizado apenas quando definitivamente necessário, apesar dos riscos potenciais.
As mães com um bebê recém-nascido que usaram este medicamento durante os últimos 3 meses de gravidez raramente podem apresentar sintomas incluindo sonolência, rigidez ou tremores musculares, problemas de alimentação ou respiração, choro constante. Se você notar algum destes sintomas em seu bebê, especialmente durante o primeiro mês, informe o médico imediatamente.
Este medicamento passa para o leite materno. Converse com seu médico antes de amamentar.
Pack Size & Price
60ml bot Price : ৳12
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