Napsec 375 (Tablet)
Manufactured by: Drug International Ltd.
Esomeprazole + Naproxen Similar medicine
Napsec 375 is indicated for
- Polyarthrite rhumatoïde
- Arthrose
- Spondylarthrite ankylosante
- Raideur articulaire
Precautions and warnings
Informez votre médecin si vous avez déjà souffert d'asthme, d'une maladie du foie, de saignements, d'ulcères, de brûlures d'estomac récurrentes, de maladies cardiaques telles qu'antécédents de crise cardiaque, d'hypertension artérielle, d'accident vasculaire cérébral, d'œdème, de rétention d'eau, de faibles taux de sodium dans le sang, de troubles sanguins tels que l'anémie, des problèmes de saignement ou de coagulation, des polypes nasaux ou un lupus avant de prendre ce médicament.
Les AINS, comme le naproxène, peuvent provoquer des difficultés rénales chez certaines personnes. Si vous êtes déshydraté, souffrez d'insuffisance cardiaque ou d'une maladie rénale, êtes une personne âgée ou prenez certains médicaments, vous êtes plus susceptible d'avoir des problèmes. Pour éviter la déshydratation, buvez beaucoup de liquides selon les conseils de votre médecin et signalez immédiatement à votre médecin tout changement dans la quantité d'urine.
Ce médicament peut provoquer des étourdissements ou une somnolence. Vous pouvez devenir étourdi ou somnolent si vous consommez de l’alcool ou du cannabis. Ne conduisez pas, n'utilisez pas de machines et ne vous engagez pas dans toute autre activité nécessitant de l'attention jusqu'à ce que vous soyez sûr de pouvoir le faire en toute sécurité. Limitez votre consommation de boissons alcoolisées. Si vous consommez du cannabis, parlez-en à votre médecin.
Ce médicament peut provoquer des saignements d'estomac. La consommation régulière d'alcool et de tabac, notamment en association avec cette prescription, peut augmenter le risque de saignement d'estomac. Pour plus d’informations, parlez-en à votre médecin ou votre pharmacien.
Side-effects
- En général
- les effets indésirables les plus fréquents dans les essais cliniques (> 5 %) : gastrite érosive
- dyspepsie
- gastrite
- diarrhée
- ulcère gastrique
- douleurs abdominales hautes
- nausées
- etc.
Drug Interactions
L'aliskiren, les inhibiteurs de l'ECA tels que le captopril et le lisinopril, les antagonistes des récepteurs de l'angiotensine II tels que le valsartan et le losartan, les corticostéroïdes tels que la prednisone, le lithium, le méthotrexate, en particulier les traitements à haute dose, et la rifampine sont quelques-uns des produits susceptibles d'interagir avec ce médicament.
Lorsqu'il est associé à d'autres médicaments pouvant provoquer des saignements, ce médicament peut augmenter le risque de saignement. Les médicaments antiplaquettaires comme le clopidogrel, ainsi que les « anticoagulants » comme le dabigatran/énoxaparine/warfarine, en sont des exemples.
Certains produits nécessitent que l’acide gastrique soit correctement absorbé par l’organisme. Étant donné que l'ésoméprazole réduit l'acide gastrique, cela peut affecter l'efficacité de ces médicaments. L'atazanavir, l'erlotinib, le nelfinavir, le pazopanib, la rilpivirine et certains antifongiques azolés comme l'itraconazole, le kétoconazole et le posaconazole font partie des produits concernés.
Contraindications
• Hypersensibilité à l'un des ingrédients de Progesic ou aux benzimidazoles substitués.
• Asthme, urticaire ou autres réactions allergiques après l'utilisation d'aspirine ou d'autres médicaments anti-inflammatoires non stéroïdiens
• Dans le cas d'un pontage aorto-coronarien (PAC), utiliser en période péri-opératoire.
• Une femme en fin de grossesse.
Mode of actions
Un AINS prototype est le naproxène, un dérivé de l'acide propionique. Il inhibe les enzymes cyclooxygénase-1 et -2 (COX-1 et -2) de manière réversible, entraînant une réduction de la synthèse des précurseurs des prostaglandines. Il possède des propriétés anti-inflammatoires, analgésiques et antipyrétiques, ainsi que l'inhibition de l'agrégation plaquettaire.
L'ésoméprazole est un inhibiteur de la pompe à protons (IPP) qui inhibe la H+/K+ ATPase dans la cellule pariétale gastrique, supprimant ainsi la production d'acide gastrique. C'est l'isomère S de l'oméprazole.
Dosage & Administration
Polyarthrite rhumatoïde, arthrose, spondylarthrite alkyllosante et dysménorrhée : 375 ou 500 mg, un comprimé deux fois par jour.
Pregnancy & Lactation
Ce médicament est interdit pendant la grossesse. Ne l'utilisez pas si vous êtes enceinte. Il peut être absorbé par la peau et les poumons, ce qui peut endommager les organes de votre enfant à naître et provoquer des handicaps congénitaux. Contrôle des naissances strict et efficace pendant le traitement et pendant six mois après l'arrêt de ce médicament. Si vous tombez enceinte, arrêtez de prendre ce médicament et parlez-en immédiatement à votre médecin.
Il n'existe aucune information spécifique indiquant si ce médicament passe ou non dans le lait maternel. Compte tenu des risques possibles pour les enfants, l'allaitement pendant l'utilisation de ce médicament est déconseillé et ce au moins deux semaines après la dernière dose. Consultez votre médecin avant d'allaiter.
Pack Size & Price
30's pack Price : ৳240
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