Beximco Pharmaceuticals Ltd.
Tyclav 1gm is indicated for
- Acute otitis media
- Acute bacterial sinusitis
- Dental abscess
- H. pylori infection
- Community-acquired pneumonia
- Acute uncomplicated UTI
- Uncomplicated gonorrhea
- Severe or recurrent resp tract infections
Precautions and warnings
History of allergy especially to cephalosporins, infectious mononucleosis, severe renal impairment.
- candida superinfection.
Potentially Fatal: Anaphylactic reaction with CV collapse esp with parenteral use.
Allopurinol may reduce renal tubular secretion of amoxicillin thus increasing the serum levels of amoxicillin. Concurrent use may reduce the efficacy of oral contraceptives.
Mode of actions
Clavulanic acid has a high affinity for and binds to certain ?-lactamases that generally inactivate amoxicillin by hydrolyzing its ?-lactam ring. Combining clavulanate potassium with amoxicillin extends the antibacterial spectrum of amoxicillin to include many bacteria normally resistant to amoxicillin and other penicillins and cephalosporins.
Dosage & Administration
Adults and children over 12 years: One 375 mg tablet 3 times a day. In severe infection one 625mg tablet 3 times a day or one 1gm tablet two times a day.
Children of 6-12 years: 2 teaspoonful Powder for Suspension every 8 hours.
Children of 1-6 years: 1 teaspoonful Powder for Suspension every 8 hours.
Children below 1 year: 25 mg/kg/day in divided doses every 8 hours.
Adults and children over 12 years: IV Injection: 1.2 g every 6-8 hours,
Children up to 3 months: 30 mg/kg every 8 hours (every 12 hours in the perinatal period and in premature infants);
child 3 months-12 years, 30 mg/kg every 6-8 hours.
Pregnancy & Lactation
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
Pack Size & Price