Zenaf 500mg (Capsule)
Manufactured by: Cosmic Chemical Industries Ltd.
Cephradine Similar medicine
Zenaf is indicated for
- Lungenentzündung
- Pharyngitis
- anfällige Infektionen
- Mittelohrentzündung
- Haut- und Hautstrukturinfektionen
- rheumatisches Fieber
- Mandelentzündung
- Atemwegsinfektionen
- Harnwegsinfektionen
- chirurgische Prophylaxe
- Infektionen des Urogenitaltrakts
- akute Prostatitis
Precautions and warnings
Patienten mit einer Penicillin-Überempfindlichkeit in der Vorgeschichte, eingeschränkter Nierenfunktion, schwangeren Frauen und Müttern, die ihre Babys mit Muttermilch füttern, sollten besondere Aufmerksamkeit gewidmet werden.
Side-effects
- Durchfall
- Übelkeit
- Erbrechen; Leukopenie
- Neutropenie
- Eosinophilie
- Hautausschlag
- Pruritus; Gelenkschmerzen; erhöhter BUN- und Kreatinspiegel; Schwindel. Potenziell tödlich: Pseudomembranöse Kolitis.
Drug Interactions
Schleifendiuretika erhöhen das Risiko einer Nephrotoxizität. Bei Verwendung von Probenecid ist die renale Clearance verringert.
Wenn nephrotoxische Medikamente wie Aminoglykoside zusammen mit Cefradin eingenommen werden, steigt das Risiko einer Nierenschädigung. Die Nierentoxizität wurde durch Diuretika wie Frusemid, Ethacrynsäure und Probenecid erhöht.
Contraindications
Porphyrie und Überempfindlichkeit gegen den Wirkstoff von Cefradin oder anderen Cephalosporinen.
Mode of actions
Cefradin ist ein Cephalosporin der ersten Generation, das den letzten Transpeptidierungsschritt der Peptidoglycan-Produktion in der bakteriellen Zellwand blockiert, indem es an ein oder mehrere Penicillin-bindende Proteine (PBPs) bindet, die Zellwandsynthese stoppt und den Zelltod der Bakterien verursacht.
Dosage & Administration
Erwachsener: PO. Anfällige Infektionen 1-2 g/Tag in 2-4 aufgeteilten Dosen. Maximal: 4 g/Tag.
IV/IM Schwere Infektionen 2–4 g/Tag in mehreren Dosen. Maximal: 8 g/Tag.
Chirurgische Prophylaxe 1-2 g präoperativ. Nachfolgende Dosen können nach Bedarf verabreicht werden.
Haut und Hautstrukturen sowie Infektionen der Atemwege: Die übliche Dosis beträgt 250 mg alle 6 Stunden oder 500 mg alle 12 Stunden.
Lobärpneumonie: 500 mg alle 6 Stunden oder 1 g alle 12 Stunden.
Harnwegsinfektion: Die übliche Dosis beträgt 500 mg alle 12 Stunden.
Magen-Darm-Infektion: 500 mg drei- bis viermal täglich.
Kinder: Oral: Die übliche Gesamtdosis beträgt 25 bis 50 mg/kg/Tag, verteilt auf 2 bis 4 gleichmäßig verteilte Dosen.
Injektion: 50 bis 100 mg/kg/Tag in 4 gleichmäßig verteilten Dosen. Die übliche Gesamtdosis kann auf bis zu 200–300 mg/kg/Tag erhöht werden.
Perioperative Prophylaxe: Die empfohlene Dosis beträgt 1–2 g intramuskulär oder intravenös; Nachfolgende parenterale oder orale Dosen werden je nach Bedarf verabreicht.
Nierenfunktionsstörung: Für Patienten, die sich einer chronischen intermittierenden Hämodialyse unterziehen: 250 mg können zu Beginn der Sitzung verabreicht werden, wiederholt nach 6–12 Stunden, dann erneut 36–48 Stunden nach der Anfangsdosis und erneut zu Beginn der nächsten Hämodialyse, wenn seit der vorherigen Dosis mehr als 30 Stunden vergangen sind.
CrCl (ml/min)
>20 500 mg alle 6 Stunden.
5-20 250 mg alle 6 Stunden.
Pregnancy & Lactation
Obwohl tierexperimentelle Reproduktionsstudien eine nachteilige Wirkung gezeigt haben und manchmal sogar kein Risiko für den Fötus nachgewiesen werden konnte, und es keine ausreichenden und gut kontrollierten Studien bei schwangeren Frauen gibt, kann dieses Arzneimittel während der Schwangerschaft nur dann angewendet werden, wenn dies unbedingt erforderlich ist.
Besprechen Sie dies mit Ihren Ärzten und teilen Sie ihnen Feedback zu diesem Arzneimittel mit.
Es liegen keine spezifischen Informationen darüber vor, ob dieses Arzneimittel über die Muttermilch auf das Baby übertragen wird. Besprechen Sie dies mit Ihrem Arzt, bevor Sie stillen.
Pack Size & Price
20's pack Price : ৳260
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