Sefacin 500mg (Capsule)
Manufactured by: Kumudini Pharma Ltd.
Cephradine Similar medicine
Sefacin is indicated for
- Pneumonia
- Faringite
- Infecções suscetíveis
- Otite média
- Infecções da pele e da estrutura da pele
- Febre reumática
- Amigdalite
- Infecções do trato respiratório
- Infecções do trato urinário
- Profilaxia cirúrgica
- Infecções do trato geniturinário
- Prostatite aguda
Precautions and warnings
Pacientes com histórico de sensibilidade à penicilina, insuficiência renal, gestantes e mães que alimentam seus bebês com leite materno devem receber atenção especial.
Side-effects
- Diarréia
- náusea
- vômito; leucopenia
- neutropenia
- eosinofilia
- erupção cutânea
- prurido; dor nas articulações; aumento de BUN e creatina; tontura. Potencialmente fatal: colite pseudomembranosa.
Drug Interactions
Os diuréticos de alça aumentam o risco de nefrotoxicidade. A depuração renal é reduzida quando a probenecida é usada.
Quando medicamentos nefrotóxicos como aminoglicosídeos são tomados com Cefradina, o risco de danos renais aumenta. A toxicidade renal foi aumentada por diuréticos como frusemida, ácido etacrínico e probenecida.
Contraindications
Porfiria e hipersensibilidade ao ingrediente ativo da cefradina ou outras cefalosporinas.
Mode of actions
A cefradina é uma cefalosporina de primeira geração que bloqueia a última etapa de transpeptidação da produção de peptidoglicano na parede celular bacteriana, ligando-se a uma ou mais proteínas de ligação à penicilina (PBPs), interrompendo a síntese da parede celular e causando a morte celular bacteriana.
Dosage & Administration
Adulto: PO Infecções suscetíveis 1-2 g/dia em 2-4 doses divididas. Máx.: 4 g/dia.
IV/IM Infecções graves 2-4 g/dia em doses divididas. Máx.: 8 g/dia.
Profilaxia cirúrgica 1-2 g pré-operatório. Doses subsequentes podem ser administradas conforme necessário.
Pele e estruturas da pele e infecção do trato respiratório: A dose habitual é de 250 mg a cada 6 horas ou 500 mg a cada 12 horas.
Pneumonia lobar: 500 mg a cada 6 horas ou 1 g a cada 12 horas.
Infecção do trato urinário: A dose habitual é de 500 mg a cada 12 horas.
Infecção do trato gastrointestinal: 500 mg três a quatro vezes ao dia.
Crianças: Oral: A dose total habitual é de 25 a 50 mg/kg/dia administrada em 2 a 4 doses divididas igualmente.
Injeção: 50 a 100 mg/kg/dia em 4 doses divididas igualmente. A dose total habitual pode ser aumentada até 200-300 mg/kg/dia.
Profilaxia perioperatória: A dose recomendada é de 1-2 g por via intramuscular ou intravenosa; doses parenterais ou orais subsequentes são administradas conforme apropriado.
Insuficiência renal: Para pacientes submetidos a hemodiálise crônica intermitente: 250 mg podem ser administrados no início da sessão, repetidos após 6-12 horas, depois novamente 36-48 horas após a dose inicial e novamente no início da próxima hemodiálise se tiverem decorrido >30 horas desde a dose anterior.
CrCl (ml/min)
>20.500 mg a cada 6 horas.
5-20 250 mg a cada 6 horas.
Pregnancy & Lactation
Embora estudos de reprodução animal tenham demonstrado um efeito adverso, mesmo por vezes incapaz de demonstrar o risco para o feto e não existam estudos adequados e bem controlados em mulheres grávidas, mas durante a gravidez, este medicamento pode ser utilizado apenas quando definitivamente necessário.
Discuta com seus médicos e dê-lhes comentários sobre este medicamento.
Não há informações específicas sobre se este medicamento é transmitido ao bebê através do leite materno. Discuta com seu médico antes de amamentar.
Pack Size & Price
20's pack Price : ৳250
Similar medicine
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