Sefrad IV/IM 500mg/vial (Injection)
Manufactured by: Sanofi Aventis (BD) Ltd.
Cephradine Similar medicine
Sefrad IV/IM is indicated for
- Pneumonia
- Faringitis
- Infeksi rentan
- Otitis media
- Infeksi Kulit dan Struktur Kulit
- Demam reumatik
- Radang Amandel
- Infeksi Saluran Pernafasan
- Infeksi Saluran Kemih
- Profilaksis Bedah
- Infeksi Saluran Genitourinari
- Prostatitis Akut
Precautions and warnings
Pasien dengan riwayat sensitivitas penisilin, gangguan ginjal, wanita hamil, dan ibu yang menyusui bayinya harus mendapat perhatian khusus.
Side-effects
- Diare
- mual
- muntah; leukopenia
- neutropenia
- eosinofilia
- ruam
- pruritus; nyeri sendi; peningkatan BUN dan kreatin; pusing. Berpotensi Fatal: Kolitis pseudomembran.
Drug Interactions
Diuretik loop meningkatkan risiko nefrotoksisitas. Klirens ginjal berkurang bila probenesid digunakan.
Ketika obat nefrotoksik seperti aminoglikosida dikonsumsi bersama Cefradine, risiko kerusakan ginjal meningkat. Toksisitas ginjal ditingkatkan oleh diuretik seperti furosemid, asam etakrinat, dan probenesid.
Contraindications
Porfiria dan hipersensitivitas terhadap bahan aktif dalam cefradine atau sefalosporin lainnya.
Mode of actions
Cefradine adalah sefalosporin generasi pertama yang menghambat langkah transpeptidasi terakhir produksi peptidoglikan di dinding sel bakteri dengan mengikat satu atau lebih protein pengikat penisilin (PBP), menghentikan sintesis dinding sel dan menyebabkan kematian sel bakteri.
Dosage & Administration
Dewasa: PO Rentan infeksi 1-2 g/hari dalam 2-4 dosis terbagi. Maks: 4 g/hari.
IV/IM Infeksi berat 2-4 g/hr dalam dosis terbagi. Maks: 8 g/hari.
Profilaksis bedah 1-2 g sebelum operasi. Dosis selanjutnya dapat diberikan sesuai kebutuhan.
Struktur kulit dan kulit serta infeksi saluran pernapasan: Dosis biasa adalah 250 mg setiap 6 jam atau 500 mg setiap 12 jam.
Pneumonia lobaris: 500 mg setiap 6 jam atau 1 gram setiap 12 jam.
Infeksi saluran kemih: Dosis biasa adalah 500 mg setiap 12 jam.
Infeksi saluran cerna: 500 mg tiga sampai empat kali sehari.
Anak-anak: Oral: Dosis total yang biasa adalah 25 sampai 50 mg/kg/hari diberikan dalam 2 sampai 4 dosis terbagi rata.
Suntikan: 50 hingga 100 mg/kg/hari dalam 4 dosis terbagi rata. Dosis total biasa dapat ditingkatkan hingga 200-300 mg/kg/hari.
Profilaksis perioperatif: Dosis yang dianjurkan adalah 1-2 gram melalui rute intramuskular atau intravena; dosis parenteral atau oral berikutnya diberikan sesuai kebutuhan.
Gangguan ginjal: Untuk pasien yang menjalani hemodialisis intermiten kronis: 250 mg dapat diberikan pada awal sesi, diulangi setelah 6-12 jam, kemudian diberikan lagi 36-48 jam setelah dosis awal, dan diberikan lagi pada awal hemodialisis berikutnya jika >30 jam telah berlalu sejak dosis sebelumnya.
CrCl (ml/menit)
>20 500 mg setiap 6 jam.
5-20 250 mg setiap 6 jam.
Pregnancy & Lactation
Meskipun penelitian pada reproduksi hewan telah menunjukkan efek buruk bahkan terkadang tidak dapat menunjukkan risiko pada janin dan belum ada penelitian yang memadai dan terkontrol dengan baik pada wanita hamil, namun selama kehamilan, obat ini dapat digunakan hanya jika benar-benar diperlukan.
Diskusikan dengan dokter Anda dan beri tahu mereka tanggapan tentang obat ini.
Belum ada informasi spesifik apakah obat ini ditularkan ke bayi melalui ASI. Diskusikan dengan dokter Anda sebelum menyusui.
Pack Size & Price
500mg vaial combipack X 1's pack Price : ৳50.19
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Manufactured by: Sanofi Aventis (BD) Ltd.
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