Tykerb 250mg (Tablet)
Manufactured by: Glaxo Operations UK Ltd., UK
Lapatinib Similar medicine
Tykerb is indicated for
- Breast cancer
Precautions and warnings
Check the patient’s left ventricular ejection fraction (LVEF) before starting treatment. Use caution in patients with moderate or severe liver problems. Be careful with patients who have, or are at risk of, a prolonged QTc interval, such as those with low potassium or magnesium levels. Monitor liver function and watch for lung symptoms that could suggest interstitial lung disease or pneumonitis. Use caution in pregnant or breastfeeding women.
Side-effects
- Anorexia
- diarrhea
- nausea
- vomiting
- rash
- fatigue
- dyspepsia
- dry skin
- stomatitis
- constipation
- abdominal pain
- palmar-plantar erythrodysesthesia
- mucosal inflammation
- pain in extremity
- back pain
- insomnia
- epistaxis
- alopecia; decreased LVEF
- nail disorders
- headache.
Drug Interactions
The concentration of this drug increases if it is taken with CYP3A4 inhibitors (like ketoconazole, itraconazole, or grapefruit juice), as well as with midazolam, irinotecan, and digoxin. Its concentration decreases if used with CYP3A4 inducers (such as rifampin, carbamazepine, or phenytoin) or with proton-pump inhibitors (like esomeprazole). The drug’s behavior in the body can also change when taken with medicines that affect P-glycoprotein or BCRP (breast cancer resistance protein), or with drugs like topotecan and rosuvastatin. Taking it with paclitaxel or docetaxel can make side effects more likely and more severe. This medicine is processed mainly by the CYP3A4 or CYP2C8 enzymes.
Contraindications
Hypersensitivity to lapatinib ditosylate
Mode of actions
This kinase inhibitor works by blocking the HER2 receptor (a type of EGF receptor) and its tyrosine kinase activity. By doing this, it may help stop the growth of new blood vessels (angiogenesis) and the multiplication of cancer cells.
Dosage & Administration
HER2 positive metastatic breast cancer 1, 250 mg (5 tab) daily on days 1-21 continuously in combination w/ capecitabine. 2,000 mg/m2/day (orally in 2 doses approx 12 hr apart) on days 1-14 in a repeating 21-day cycle.
Hormone receptor positive, HER2 positive metastatic breast cancer Recommended dose: 1,500 mg (6 tab) continuously in combination w/ letrozole. All doses to be given once daily as a single dose.
Pregnancy & Lactation
This medicine is not allowed during pregnancy. Do not use it if you are pregnant. It can be absorbed through the skin and lungs caused can damage your unborn child’s organs and cause congenital disabilities. Strict effective birth control during treatment and for six months after stopping this medicine. If you do become pregnant, stop taking this medicine and discuss your doctor right away.
There is no specific information on whether this medicine passes into breast milk or not. Considering the possible risks for the children, breastfeeding while using this medicine is not recommended and at least two weeks after the last dose. Consult your doctor before breastfeeding.
Pack Size & Price
250 mg x 70's pack Price : ৳24961.3
Similar medicine
Manufactured by: Glaxo Operations UK Ltd., UK
Click here to see more similar medicines
There are few similar medicines of Tykerb are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.
-
Are you looking medicine for Breast cancer ?
Capecitabine is indicated for Breast cancer, Colorectal cancer, Gastric cancer, Oesophageal cancer
List of medicines using CapecitabineDocetaxel is indicated for Breast cancer, Lung cancer, Prostate cancer, Stomach cancer, Head/neck cancer
List of medicines using DocetaxelEverolimus is indicated for Breast cancer, Kidney cancer, Renal transplant, Liver transplant, Neuroendocrine tumors, Renal cell carcinoma, Astrocytoma, Renal angiomyolipoma, Tuberous sclerosis
List of medicines using EverolimusIfosfamide is indicated for Breast cancer, Lung cancer, Ovarian cancer, Lymphoma, Testicular cancer, Soft tissue sarcoma, Osteogenic sarcoma, Cervical cancer
List of medicines using IfosfamideNorethisterone is indicated for Breast cancer, Metropathia haemorrhagica (dysfunctional uterine bleeding), Premenstrual syndrome, Contraception, Endometriosis, Menorrhagia, Menopausal HRT
List of medicines using NorethisteronePaclitaxel is indicated for Ovarian carcinoma, Breast cancer, Lung cancer, Kaposi's sarcoma
List of medicines using PaclitaxelVinorelbine is indicated for Breast cancer, Ovarian cancer, Cervical cancer, Non-small cell lung cancer
List of medicines using VinorelbineEpirubicin Hydrochloride is indicated for Acute leukaemias; Lymphoma; Multiple myeloma, Breast cancer, Bladder carcinoma
List of medicines using Epirubicin HydrochlorideEstrogens is indicated for Breast cancer, Prostate cancer, Hormone replacement therapy, Oral contraceptives
List of medicines using EstrogensMelphanlan is indicated for Breast cancer, Ovarian cancer, Multiple myeloma, Neuroblastoma, Soft tissue sarcoma, Malignant melanoma, Retinoblastoma, Polycythaemia vera
List of medicines using Melphanlan
