Minomal-R SR 600mg (Tablet)
Manufactured by: Pacific Pharmaceuticals Ltd.
Aminophylline Similar medicine
Minomal-R SR is indicated for
- 氣喘、急性支氣管痙攣、慢性支氣管炎、肺氣腫、慢性阻塞性肺病
Precautions and warnings
新生兒、老年人、哺乳期、懷孕、心臟/肝臟疾病、消化性潰瘍、甲狀腺機能亢進、高血壓、癲癇、心臟衰竭、慢性酒精中毒、急性發燒疾病、慢性酒精中毒。
Side-effects
- 噁心、嘔吐、腹痛、腹瀉、頭痛、失眠、頭暈、焦慮、煩躁；顫抖、心悸。 潛在致命：靜脈注射過快後出現抽搐、心律不整、低血壓和猝死。
Drug Interactions
不是黃嘌呤的黃嘌呤。 抗心律不整藥、西咪替丁、雙硫崙、氟伏沙明、幹擾素、大環內酯類抗生素、喹諾酮類、口服避孕藥、噻菌靈和維洛嗪都會降低清除率。 苯妥英、抗驚厥藥、利托那韋、利福平、磺吡酮和吸菸都會加速清除。 2-激動劑、皮質類固醇和利尿劑。
可能致命：使用擬交感神經藥和氟烷會增加心律不整的風險。 泮庫溴銨會引起心跳過速。 β-阻斷劑會減慢新陳代謝。 喹諾酮類藥物和氯胺酮都會增加驚厥的可能性。
Contraindications
過敏。
Mode of actions
茶鹼和乙二胺結合形成氨茶鹼。 乙二胺不活潑，可增加茶鹼在水中的溶解度。 茶鹼可鬆弛支氣管平滑肌。 由於磷酸二酯酶抑制、腺苷受體拮抗作用、前列腺素拮抗作用以及對細胞內鈣的影響而導致細胞內 cAMP 增加，這些都是建議的解釋。
Dosage & Administration
口服
慢性支氣管痙攣
成人：作為水合物：最初，225-450 mg bid，必要時增加。
兒童：>3 歲：作為改良釋放水合物：每天 12 mg/kg，1 週後分 2 次劑量增加至每天 24 mg/kg。
靜脈注射
急性嚴重支氣管痙攣
成人：負荷劑量：5 mg/kg（理想體重）或 250-500 mg（25 mg/ml），緩慢注射或輸注 20-30 分鐘。 維持輸注劑量：0.5 mg/kg/hr。 最大速率：25 毫克/分鐘。
兒童：負荷劑量：與成人劑量相同。 維持劑量：6個月至9歲：1 mg/kg/小時，10-16歲：0.8 mg/kg/小時。
老年人：可能需要減少劑量。
肝功能損害：可能需要減少劑量。
Pregnancy & Lactation
雖然動物生殖研究顯示對胎兒有不良影響，並且在孕婦中沒有充分且良好對照的研究，但在懷孕期間，儘管存在潛在風險，但在確實需要時可以使用該藥物。
在懷孕最後 3 個月內使用這種藥物的新生兒母親可能很少會出現困倦、肌肉僵硬或顫抖、餵食或呼吸困難、持續哭泣等症狀。 如果您發現寶寶有任何這些症狀，尤其是在第一個月內，請立即告訴醫生。
這種藥物會進入母乳。 哺乳前請先諮詢您的醫生。
Pack Size & Price
20's pack Price : ৳72
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