Co-valtin 5/80mg (Tablet)
Manufactured by: Acme Laboratories Ltd.
Amlodipine + Valsartan Similar medicine
Co-valtin is indicated for
- Hipertensi
Precautions and warnings
CHF, sindrom sinus sakit, disfungsi ventrikel parah, kardiomiopati hipertrofik, dan stenosis aorta parah merupakan gejala gangguan fungsi hati atau ginjal. Pada pasien dengan stenosis subaortik hipertrofik idiopatik, gunakan dengan hati-hati. Anak-anak, orang tua. Laktasi dan kehamilan.
Side-effects
- Sakit kepala
- edema perifer
- kelelahan
- perasaan mengantuk
- mual
- sakit perut
- muka memerah
- pencernaan yg terganggu
- jantung berdebar
- pusing. Jarang pruritus
- ruam
- dyspnoea
- asthenia
- kram otot. Berpotensi Fatal: Hipotensi
- bradikardia
- keterlambatan sistem konduktif dan CCF.
Drug Interactions
Amlodipine: Bila digunakan dengan inhibitor CYP3A4, konsentrasi plasma dapat meningkat (misalnya antijamur azole, ritonavir). Simvastatin dan pengobatan bersamaan dapat meningkatkan risiko miopati, termasuk rhabdomyolysis. Kadar plasma Conivaptan dan ciclosporin dapat meningkat.
Valsartan: Bila digunakan dengan NSAID, berpotensi melawan efek hipotensi dan meningkatkan risiko gangguan ginjal. Dengan diuretik hemat K, suplemen K, atau pengganti garam yang mengandung K, terdapat risiko hiperkalemia yang lebih tinggi.
Bila diberikan bersamaan dengan aliskiren pada penderita diabetes dan gagal ginjal, terdapat peningkatan risiko hipotensi, hiperkalemia, dan kelainan fungsi gangguan ginjal (termasuk gagal ginjal akut).
Contraindications
Hipersensitivitas terhadap dihidropiridin diketahui.
Mode of actions
Amlodipine melemaskan otot polos arteri perifer dan koroner. Selama depolarisasi, ia menghambat masuknya ion Ca ke saluran lambat atau saluran sensitif tegangan tertentu pada otot polos pembuluh darah dan jantung, sehingga mengakibatkan vasodilatasi koroner. Pada pasien dengan angina vasospastik, hal ini juga meningkatkan pengiriman oksigen miokard.
Valsartan adalah antagonis reseptor angiotensin II tipe 1 (AT1) yang menurunkan tekanan darah dengan memblokir vasokonstriksi yang diinduksi angiotensin II, produksi aldosteron, dan reabsorpsi natrium di ginjal.
Dosage & Administration
Dewasa: PO Mulai dengan 5 mg/160 mg sekali sehari.
Dapat meningkatkan dosis setelah minimal 2 minggu, tidak melebihi 10 mg/hari amlodipine dan 320 mg/hari valsartan sekali sehari jika diperlukan.
Pregnancy & Lactation
Meskipun penelitian pada reproduksi hewan menunjukkan efek buruk pada janin dan belum ada penelitian yang memadai dan terkontrol dengan baik pada wanita hamil, namun selama kehamilan, obat ini dapat digunakan tepat ketika benar-benar diperlukan meskipun ada potensi risikonya.
Penelitian lain menunjukkan bahwa obat ini tidak diperbolehkan selama kehamilan. Jangan gunakan jika Anda sedang hamil. Dapat diserap melalui kulit dan paru-paru sehingga dapat merusak organ tubuh anak Anda yang belum lahir dan menyebabkan cacat bawaan. Alat kontrasepsi yang efektif dan ketat selama pengobatan dan selama enam bulan setelah menghentikan obat ini. Jika Anda hamil, hentikan penggunaan obat ini dan segera diskusikan dengan dokter Anda.
Belum ada informasi spesifik apakah obat ini masuk ke dalam ASI atau tidak. Mengingat kemungkinan risiko pada anak-anak, menyusui saat menggunakan obat ini tidak dianjurkan dan setidaknya dua minggu setelah dosis terakhir. Konsultasikan dengan dokter Anda sebelum menyusui.
Pack Size & Price
3x10's pack Price : ৳270
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There are few similar medicines of Co-valtin are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.
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