C-quin 250mg (Tablet)
Manufactured by: Opsonin Pharma Limited
Chloroquine Phosphate Similar medicine
C-quin is indicated for
- Artritis reumatoid
- Malaria
- Lupus eritematosus sistemik
- SLE
- Amoebiasis
Precautions and warnings
Jangan gunakan obat ini pada penderita psoriasis, penyakit darah atau sistem saraf, miastenia gravis, masalah hati atau ginjal, defisiensi G6PD, epilepsi, atau pada anak-anak. Ini juga harus dihindari selama kehamilan dan menyusui. Saat memberikan obat ini melalui infus, masukkan secara perlahan untuk mengurangi risiko gangguan jantung.
Side-effects
- Retinopati
- rambut rontok
- fotosensitifitas
- tinitus
- miopati (terapi jangka panjang). Psikosis
- kejang
- leukopenia dan jarang anemia aplastik
- hepatitis
- gangguan GI
- pusing
- hipokalemia
- sakit kepala
- pruritus
- urtikaria
- kesulitan akomodasi penglihatan. Berpotensi Fatal: Serangan jantung dan pernafasan
- kolaps CV
- kejang
- koma.
Drug Interactions
Mengonsumsi fenilbutazon secara bersamaan dapat membuat Anda lebih mungkin mengalami ruam kulit, mengurangi kinerja neostigmin dan piridostigmin, serta menurunkan jumlah ampisilin yang diserap tubuh Anda. Simetidin dapat meningkatkan jumlah klorokuin dalam darah Anda dengan memperlambat penguraiannya.
**Risiko Serius:**
- Ketika klorokuin dikonsumsi dengan halofantrine atau obat lain yang mempengaruhi irama jantung (seperti amiodarone), ada kemungkinan lebih tinggi terjadinya aritmia jantung yang berbahaya.
- Risiko kejang juga lebih besar bila klorokuin dikonsumsi bersama meflokuin.
- Antasida dapat menurunkan penyerapan klorokuin, sehingga sebaiknya diminum dengan jarak minimal 4 jam satu sama lain.
- Jarang terjadi, reaksi kulit yang parah (sindrom Stevens-Johnson) dapat terjadi jika klorokuin dikonsumsi dengan pirimetamin atau sulfadoksin.
- Mengonsumsi quinacrine dengan klorokuin dapat meningkatkan risiko efek samping.
Contraindications
Jangan gunakan jika Anda memiliki alergi terhadap obat, kemungkinan atau sudah dipastikan resisten terhadap infeksi P. falciparum, porfiria, masalah retina, atau jika Anda sedang mengonsumsi obat lain yang berbahaya bagi hati.
Mode of actions
Klorokuin digunakan untuk mencegah malaria dan mengobati serangan malaria mendadak. Ia bekerja dengan baik melawan tahapan darah *Plasmodium vivax*, *P. malariae*, dan *P. falciparum*. Obat tersebut meningkatkan pH di dalam vakuola makanan parasit, sehingga mengganggu pencernaan hemoglobin dan mempengaruhi cara parasit membuat protein. Klorokuin juga membantu dalam mengobati amoebiasis di luar usus. Untuk rheumatoid arthritis (RA), klorokuin dan obat serupa hidroksiklorokuin dapat membantu memperlambat perkembangan penyakit—dan hidroksiklorokuin lebih efektif.
Dosage & Administration
Dewasa: PO Malaria akut Sebagai dasar: Awal: 600 mg, kemudian 300 mg 6-8 jam kemudian pada hari ke-1. Lanjutkan dengan 300 mg/hari pada hari ke-2 dan 3.
Profilaksis malaria Sebagai dasar: 300 mg/minggu, dimulai 1 minggu sebelum paparan, dilanjutkan setiap minggu dan setidaknya 4 minggu setelah paparan.
Diskoid dan SLE; Artritis reumatoid Sebagai dasar: Awal: 150 mg/hari. Maks: 2,5 mg/kg/hari.
Amoebiasis hati Sebagai basa: Dengan emetine atau dehydroemetine: 600 mg/hari selama 2 hari kemudian 300 mg/hari selama 2-3 minggu.
IV Malaria berat Sebagai dasar: 25 mg/kg diberikan dalam beberapa infus selama 30-32 jam.
Pregnancy & Lactation
Meskipun penelitian pada reproduksi hewan menunjukkan efek buruk pada janin dan belum ada penelitian yang memadai dan terkontrol dengan baik pada wanita hamil, namun selama kehamilan, obat ini dapat digunakan tepat ketika benar-benar diperlukan meskipun ada potensi risikonya.
Ibu dengan bayi baru lahir yang telah menggunakan obat ini selama 3 bulan terakhir kehamilan mungkin jarang mengalami gejala termasuk mengantuk, otot kaku atau gemetar, kesulitan makan atau bernapas, dan menangis terus-menerus. Jika Anda melihat gejala-gejala ini pada bayi Anda terutama pada bulan pertama, segera beri tahu dokter.
Obat ini masuk ke dalam ASI. Bicaralah dengan dokter Anda sebelum menyusui.
Pack Size & Price
50's pack Price : ৳
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