Indomethacin 25 mg (Capsule)
Manufactured by: Albion Laboratories Ltd.
Indomethacin Similar medicine
Indomethacin is indicated for
- Rheumatoid arthritis
- ankylosing spondylitis
- and osteoarthritis (degenerative joint disease)
- gout
- acute non-articular rheumatism (bursitis
- synovitis
- tendinitis).
Precautions and warnings
This medicine should be used with caution in patients who have heart disease or risk factors for heart problems, fluid retention, a history of stomach issues (like bleeding or ulcers), mental health conditions (such as depression or other psychiatric disorders), epilepsy, or Parkinson’s disease. It should also be used carefully in people with infections that are under control, since it can hide the signs and symptoms of infection. Special care is needed for patients with liver or kidney problems, older adults, children, and women who are pregnant or breastfeeding.
Side-effects
- Headaches
- usually in the morning
- mild vertigo may occur during the early weeks of therapy. These symptoms are transient
- usually disappear with continued use or by reduction of the dose. Gastrointestinal reactions such as nausea
- vomiting
- diarrhoea
- epigastric
- abdominal pain are often due to large doses of the drug
- disappear when the dose is reduced.
Drug Interactions
Indometacin can increase methotrexate levels in the blood. There is a higher risk of stomach and intestinal bleeding if indometacin is taken with warfarin. It may make blood pressure medicines like hydralazine, furosemide, beta-blockers (such as atenolol, propranolol, oxprenolol), or thiazide diuretics less effective. The chance of high potassium in the blood goes up when used with potassium-sparing diuretics, ACE inhibitors, or potassium supplements. Indometacin can also increase kidney damage if taken with ciclosporin or triamterene. Probenecid can increase indometacin levels in the blood. In premature newborns, it may raise aminoglycoside (such as amikacin or gentamicin) levels. Taking indometacin with haloperidol may cause stronger side effects of antipsychotic drugs, like severe drowsiness and confusion. Antacids containing aluminum or magnesium may help reduce stomach problems caused by indometacin.
**Warning (Potentially Fatal):** Diflunisal can decrease kidney clearance and raise indometacin levels, which can cause deadly stomach or intestinal bleeding.
Contraindications
Indomethacin should not be used in people who currently have ulcers, gastritis, or active ulcerative colitis. It should also be avoided if someone has ever had an allergic reaction to it. If a person has had these stomach or bowel problems in the past, indomethacin should be used carefully.
Mode of actions
Indometacin is a type of medicine that belongs to the indole acetic acid group. It helps reduce inflammation, relieve pain, and lower fever. It works by blocking the enzymes cyclooxygenase-1 and -2 (COX-1 and COX-2), which leads to less production of prostaglandins, the substances that cause inflammation and pain.
Dosage & Administration
By mouth, rheumatic disease, 50-200 mg daily in divided doses, with food. Acute gout, 150-200 mg daily in divided doses. Dismenorrhea, upto 75 mg daily.
Children: Not recommended
Rectal
Pain and inflammation associated with musculoskeletal and joint disorders
Adult: As supp: 100 mg to be inserted at night and repeated in the morning if necessary.
Pregnancy & Lactation
This medicine is not allowed during pregnancy. Do not use it if you are pregnant. It can be absorbed through the skin and lungs caused can damage your unborn child’s organs and cause congenital disabilities. Strict effective birth control during treatment and for six months after stopping this medicine. If you do become pregnant, stop taking this medicine and discuss your doctor right away.
There is no specific information on whether this medicine passes into breast milk or not. Considering the possible risks for the children, breastfeeding while using this medicine is not recommended and at least two weeks after the last dose. Consult your doctor before breastfeeding.
Pack Size & Price
100's pack Price : ৳
Similar medicine
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Manufactured by: Albion Laboratories Ltd.
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There are few similar medicines of Indomethacin are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.
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