Precautions and warnings

Be cautious when using in people with pre-diabetes or diabetes, gout, lupus (SLE), liver or kidney problems, or high cholesterol. Make sure any imbalances in electrolytes are fixed before starting treatment. There is a risk of allergic reactions if you are sensitive to sulfonamides, sulfonylureas, carbonic anhydrase inhibitors, or certain diuretics (like thiazides and loop diuretics). Use with care if the patient is breastfeeding.

Drug Interactions

The blood pressure-lowering and kidney-related side effects of ACE inhibitors can become stronger. The body may not absorb the medication as well if you take bile acid sequestrants. Diazoxide can increase the risk of high blood sugar. This drug may raise the levels of dofetilide in the blood and make heart rhythm problems more likely. It can also lower how much lithium your body gets rid of. Drinking alcohol may make the blood pressure-lowering effect stronger.

Serious risks: Taking this medication with ciclosporin can cause kidney damage. Severe imbalances in body salts can happen if taken with furosemide.

Contraindications

Anuria; hepatic coma or pre-coma. Pregnancy.

Mode of actions

Metolazone is a type of water pill similar to thiazide diuretics. It works by blocking the reabsorption of sodium in the kidneys’ distal tubules, which causes the body to get rid of more sodium, water, potassium, and hydrogen ions through urine.

Dosage & Administration

Oral
Hypertension
Adult: Initially, 1.25 mg daily, adjusted after 3-4 wk according to response. Usual dose: 2.5-5 mg daily, either alone or with other antihypertensives. Maintenance dose: 5 mg on alternate days. Formulations with enhanced bioavailability: 0.5-1 mg daily.
Elderly: Initially, 2.5 mg/day or every other day.

Oedema
Adult: 5-10 mg daily, increased if necessary to 20 mg daily. Max: 80 mg in 24 hr.
Elderly: Initially, 2.5 mg/day or every other day.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect even sometimes unable to demonstrate the risk on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required.

Discuss with your doctors and tell them feedback about this medicine.

There is no specific information about whether this medicine is passed on to the baby through breast milk. Discuss with your doctor before breastfeeding.

Pack Size & Price