Carmapine 100mg/5ml (Suspension)
Manufactured by: Incepta Pharmaceuticals Ltd.
Carbamazepine Similar medicine
Carmapine is indicated for
- 癲癇、精神分裂症、雙向情感障礙、三叉神經痛
Precautions and warnings
母乳哺育、心臟病、肝臟或腎臟問題、血液病史或對其他藥物的不良反應、青光眼、皮膚問題、老年人和服用 MAO 抑制劑的患者都應謹慎使用。 不要突然停止治療。
Side-effects
- 頭暈、嗜睡、共濟失調；口乾、腹痛、噁心、嘔吐、厭食；白血球減少、蛋白尿、腎衰竭、心臟衰竭和低鈉血症。 潛在致命：粒細胞缺乏症、再生障礙性貧血、肝衰竭、嚴重剝脫性皮膚炎和史蒂文斯-約翰遜症候群。
Drug Interactions
- 當與 CYP3A4 抑制劑（如西咪替丁）一起服用時，該藥物的血漿濃度會上升，而與 CYP3A4 誘導劑（如順鉑）一起服用時，該藥物的血漿濃度會下降。
- 與鋰一起服用會增加神經相關副作用的風險。
- 它會使荷爾蒙避孕的效果降低。
- 有些藥物（洛沙平、喹硫平、撲米酮、丙加必特、丙戊酸、丙戊酸）可增加其活性代謝物卡馬西平-10,11-環氧化物的血液濃度。
- 它可能會提高環磷酰胺的水平。
- 它可能會降低血液中阿立哌唑、他克莫司、替西羅莫司和拉帕替尼的含量。
- 與異煙肼一起服用可能會增加肝損傷的風險。
- 與利尿劑（如氫氯噻嗪或速尿）一起服用時，低血鈉（低鈉血症）的風險較高。
嚴重警告：
- 它可能會降低奈法唑酮及其活性成分的血液濃度，這可能是危險的。
- 與 MAO 抑制劑一起服用可能會引起毒性反應，甚至可能危及生命。
Contraindications
過敏症；骨髓抑制；卟啉症，懷孕。
Mode of actions
卡馬西平透過降低神經活動和阻斷某些類型的神經反應來發揮作用。 它有助於治療局部性癲癇發作和全身性癲癇發作，以及兩種類型的混合性癲癇發作，但對小發作（失神）癲癇發作無效。 它還可以減輕或停止三叉神經痛和舌咽神經痛引起的疼痛。
Dosage & Administration
癲癇：成人和 12 歲以上兒童 - 初始劑量：每日兩次 200 毫克對於片劑和 XR 片劑，或每日 1 茶匙懸浮液（400 毫克/天）。 每週增加一次，每日兩次或三次，直至 200 毫克。 或 q.i.d.任一製劑的方案直至獲得最佳反應。
12-15歲兒童劑量一般不超過每日1000毫克，15歲以上患者每日劑量不得超過1200毫克。 在極少數情況下，成人使用的劑量高達每日 1600 毫克。
維持：通常每天800-1200毫克。 6-12 歲兒童 - 初始劑量：每日兩次，每次 100 毫克對於片劑或 XR 片劑，或 1/2 茶匙，每日一次懸浮液（200 毫克/天）。 每週增加一次，每日兩次，每日增加至 100 毫克。 或 T.I.D.或 q.i.d.任一製劑的方案直至獲得最佳反應。 劑量一般每日不應超過1000毫克。 維持：通常每天 400-800 毫克。
6 歲以下兒童 - 初始：10-20 毫克/公斤/天，每日兩次或t.i.d.片劑或 q.i.d.作為懸浮液。 每週增加劑量，以達到最佳臨床反應，每日三次給藥。 或 q.i.d.維持：通常，每日劑量低於 35 mg/kg 即可達到最佳臨床反應。 如果尚未達到滿意的臨床反應，則應測量血漿水平以確定其是否在治療範圍內。 對於劑量高於 35 mg/kg/24 小時的卡馬西平的使用安全性，尚無建議。
合併治療：卡馬西平可單獨使用或與其他抗驚厥藥物一起使用。 當添加到現有的抗驚厥治療中時，應逐漸添加該藥物，同時維持或逐漸減少其他抗驚厥藥物，但苯妥英除外，苯妥英可能需要增加。
三叉神經痛：初始：第一天，每日兩次，每次 100 毫克。 對於片劑或 XR 片劑，或 1/2 茶匙，每日一次混懸劑，每日總劑量為 200 mg。 對於片劑或 XR 片劑，每日劑量可增加高達 200 毫克/天，每 12 小時增加 100 毫克，或每日 50 毫克（1/2 茶匙）。 僅在需要實現免於疼痛的情況下暫停。 每日總劑量不得超過 1200 毫克。
維持：大多數患者每天服用 400-800 毫克即可維持疼痛控制。 然而，有些患者可能需要每天維持 200 毫克的劑量，而其他患者可能需要每天 1200 毫克的劑量。 在整個治療期間至少每3個月應嘗試將劑量減少至最低有效水平，甚至停藥。 片劑或糖漿可以在不進餐的情況下服用。
Pregnancy & Lactation
懷孕期間不允許使用這種藥物。 如果您懷孕了，請勿使用它。 它可以透過皮膚和肺部吸收，從而損害未出生孩子的器官並導致先天性殘疾。 治療期間及停藥後六個月內嚴格有效的節育。 如果您確實懷孕了，請停止服用此藥並立即與您的醫生討論。
沒有關於這種藥物是否會進入母乳的具體資訊。 考慮到兒童可能存在的風險，不建議在使用該藥物時進行母乳喂養，並且至少在最後一次用藥後兩週進行母乳喂養。 哺乳前請先諮詢您的醫生。
Pack Size & Price
100ml bot Price : ৳250
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