Cabretol 100mg/5ml (Suspension)
Manufactured by: Renata Limited
Carbamazepine Similar medicine
Cabretol is indicated for
- Epilepsy
- Schizophrenia
- Bipolar disorder
- Trigeminal neuralgia
Precautions and warnings
Breastfeeding, heart disease, liver or kidney problems, history of blood disorders or bad reactions to other medications, glaucoma, skin problems, elderly people, and patients taking MAO inhibitors should all use caution. Do not stop the treatment suddenly.
Side-effects
- Dizziness
- drowsiness
- ataxia; dry mouth
- abdominal pain
- nausea
- vomiting
- anorexia; leucopenia
- proteinuria
- renal failure
- heart failure
- hyponatraemia. Potentially Fatal: Agranulocytosis
- aplastic anaemia
- hepatic failure
- severe exfoliative dermatitis
- Stevens-Johnson syndrome.
Drug Interactions
- Plasma levels of this medicine go up when taken with CYP3A4 inhibitors (like cimetidine) and go down with CYP3A4 inducers (like cisplatin).
- Taking it with lithium increases the risk of nerve-related side effects.
- It can make hormonal birth control less effective.
- Some drugs (loxapine, quetiapine, primidone, progabide, valproic acid, valpromide) can increase the blood level of its active metabolite, carbamazepine-10,11-epoxide.
- It may raise the levels of cyclophosphamide.
- It may lower the amount of aripiprazole, tacrolimus, temsirolimus, and lapatinib in your blood.
- It may increase the risk of liver damage when taken with isoniazid.
- There’s a higher risk of low blood sodium (hyponatraemia) when taken with diuretics (like hydrochlorothiazide or furosemide).
Serious warnings:
- It may lower blood levels of nefazodone and its active ingredients, which could be dangerous.
- Taking it with MAO inhibitors may cause toxic, possibly life-threatening reactions.
Contraindications
Hypersensitivity; bone marrow depression; porphyria, pregnancy.
Mode of actions
Carbamazepine works by lowering nerve activity and blocking certain types of nerve responses. It is helpful in treating both partial and general seizures, as well as a mix of both types, but it does not work for petit mal (absence) seizures. It can also reduce or stop pain caused by trigeminal and glossopharyngeal neuralgia.
Dosage & Administration
Epilepsy: Adults and children over 12 years of age - Initial: Either 200 mg b.i.d. for tablets and XR tablets, or 1 teaspoon q.i.d. for suspension (400 mg/day). Increase at weekly intervals by adding up to 200 mg/day using a b.i.d or a t.i.d. or q.i.d. regimen of the either formulations until the optimal response is obtained.
Dosage generally should not exceed 1000 mg daily in children 12-15 years of age, and 1200 mg daily in patients above 15 years of age. Doses up to 1600 mg daily have been used in adults in rare instances.
Maintenance: usually 800-1200 mg daily. Children 6-12 years of age - Initial: Either 100 mg b.i.d. for tablets or XR tablets, or 1/2 teaspoon q.i.d. for suspension (200 mg/day). Increase at weekly intervals by adding up to 100 mg/day using a b.i.d. or a t.i.d. or q.i.d. regimen of the either formulations until the optimal response is obtained. Dosage generally should not exceed 1000 mg daily. Maintenance: usually 400-800 mg daily.
Children under 6 years of age - Initial: 10-20 mg/kg/day b.i.d. or t.i.d. as tablets, or q.i.d. as suspension. Increase weekly to achieve optimal clinical response administered t.i.d. or q.i.d. Maintenance: Ordinarily, optimal clinical response is achieved at daily doses below 35 mg/kg. If satisfactory clinical response has not been achieved, plasma levels should be measured to determine whether or not they are in the therapeutic range. No recommendation regarding the safety of Carbamazepine for use at doses above 35 mg/kg/24 hours can be made.
Combination therapy: Carbamazepine may be used alone or with other anticonvulsants. When added to existing anticonvulsant therapy, the drug should be added gradually while the other anticonvulsants are maintained or gradually decreased, except phenytoin, which may have to be increased.
Trigeminal Neuralgia: Initial: On the first day, either 100 mg b.i.d. for tablets or XR tablets, or 1/2 teaspoon q.i.d. for suspension, for a total daily dose of 200 mg. This daily dose may be increased by up to 200 mg/day using increments of 100 mg every 12 hours for tablets or XR tablets, or 50 mg (1/2 teaspoon) q.i.d. for suspension, only as needed to achieve freedom from pain. A total dose of 1200 mg daily shouldn't be exceeded.
Maintenance: Control of pain can be maintained in most patients with 400-800 mg daily. However, some patients may be maintained on as little as 200 mg daily, while others may require as much as 1200 mg daily. At least once every 3 months throughout the treatment period, attempts should be made to reduce the dose to the minimum effective level or even to discontinue the drug. The tablets or syrup can be taken without regards to meal.
Pregnancy & Lactation
This medicine is not allowed during pregnancy. Do not use it if you are pregnant. It can be absorbed through the skin and lungs caused can damage your unborn child’s organs and cause congenital disabilities. Strict effective birth control during treatment and for six months after stopping this medicine. If you do become pregnant, stop taking this medicine and discuss your doctor right away.
There is no specific information on whether this medicine passes into breast milk or not. Considering the possible risks for the children, breastfeeding while using this medicine is not recommended and at least two weeks after the last dose. Consult your doctor before breastfeeding.
Pack Size & Price
100ml bot Price : ৳301.13
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