Acuren 50mg (Tablet)
Manufactured by: Incepta Pharmaceuticals Ltd.
Hydrochlorothiazide Similar medicine
Acuren is indicated for
- Hypertension
- Congestive heart failure
- Oedema
- Diabetes insipidus
- Renal tubular acidosis
Precautions and warnings
People with existing problems like electrolyte imbalances, liver cirrhosis, serious heart failure, swelling (oedema), older age, or kidney issues need extra caution. Watch for symptoms of fluid or electrolyte problems. Be careful if the patient has liver problems, diabetes, gout, high cholesterol, high calcium, or high uric acid levels. Heart tests (ECG) may show heart muscle thickening or unusual heartbeats. This medicine may also make lupus (SLE) worse or appear in people who are prone to it.
Side-effects
- Volume depletion
- electrolyte imbalance
- dry mouth
- thirst
- lethargy
- drowsiness
- muscle pain
- cramps
- hypotension
- hypersensitivity reactions e.g. rashes
- photosensitivity
- thrombocytopenia
- jaundice
- pancreatitis; fatigue
- weakness; may precipitate an attack of gout; impotence
- hyperglycaemia; anorexia
- gastric irritation
- nausea
- vomiting
- constipation
- diarrhoea
- sialadenitis
- dizziness
- raised Ca concentration. Potentially Fatal: Hypersensitivity reactions.
Drug Interactions
This medication can make lithium more toxic. It may cause a stronger drop in blood pressure when taken with barbiturates or narcotics. It increases the effect of muscle relaxants like atracurium. The risk of low potassium is higher if taken with corticosteroids, corticotropin, or beta-2 agonists like salbutamol. Its blood pressure lowering effects add to those of other antihypertensive drugs. Medicines that make the body retain fluid—including corticosteroids, NSAIDs, or carbenoxolone—can make this medication less effective at lowering blood pressure. NSAIDs can also increase the risk of kidney problems. Lastly, this medication can make diabetes drugs less effective.
Contraindications
Do not use in people with severe liver or kidney problems, Addison’s disease, high calcium levels in the blood, or if you cannot produce urine (anuria). Also avoid if you are allergic to sulfonamides. Do not use during pregnancy or while breastfeeding.
Mode of actions
Hydrochlorothiazide stops the body from reabsorbing sodium and chloride in the distal tubules of the kidneys. This causes more sodium, water, potassium, and hydrogen ions to be removed from the body in the urine.
Dosage & Administration
Oral
Hypertension
Adult: Initially, 12.5 mg, may increase to 25-50 mg once daily as necessary either alone or w/ other antihypertensives.
Child: 2-12 yr 1-2 mg/kg/day in 1-2 divided doses Max: 100 mg daily.
Elderly: 12.5-25 mg once daily, titrate as necessary in increments of 12.5 mg.
Oedema associated w/ heart failure Usual: 25-100 mg/day in the morning, may reduce based on response. Severe: Up to 200 mg/day.
Child: 2-12 yr 1-2 mg/kg/day in 1-2 divided doses Max: 100 mg daily.
Elderly: 12.5-25 mg once daily, titrate as necessary in increments of 12.5 mg.
Nephrogenic diabetes insipidus Initial: Up to 100 mg/day.
Pregnancy & Lactation
This medicine is not allowed during pregnancy. Do not use it if you are pregnant. It can be absorbed through the skin and lungs caused can damage your unborn child’s organs and cause congenital disabilities. Strict effective birth control during treatment and for six months after stopping this medicine. If you do become pregnant, stop taking this medicine and discuss your doctor right away.
There is no specific information on whether this medicine passes into breast milk or not. Considering the possible risks for the children, breastfeeding while using this medicine is not recommended and at least two weeks after the last dose. Consult your doctor before breastfeeding.
Pack Size & Price
100's pack Price : ৳100
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Manufactured by: Incepta Pharmaceuticals Ltd.
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There are few similar medicines of Acuren are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.
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