Arolef 20mg (Tablet)
Manufactured by: General Pharmaceuticals Ltd.
Leflunomide Similar medicine
Arolef is indicated for
- Rheumatoid arthritis
- Psoriatic arthritis
Precautions and warnings
If you have kidney or liver problems, or if you are a woman who could become pregnant, you need to be careful when taking this medication. Women who might get pregnant should use effective birth control, and stop taking leflunomide before trying to become pregnant. Before starting treatment, your liver function should be checked. Regularly monitor your blood pressure and blood counts during treatment. Do not drink alcohol while taking this medication.
Side-effects
- Thrombocytopenia
- anaphylaxis
- eosinophilia
- leukopenia
- pancytopenia. Headache
- dizziness
- weakness
- bronchitis
- urinary tract infection
- alopecia
- rash
- dry skin
- eczema
- pruritus
- hypokalaemia
- weight loss
- arthralgia
- joint disorder
- leg cramps
- rhinitis
- sinusitis
- hypertension
- diarrhoea
- nausea
- abdominal pain
- synovitis
- tenosynovitis
- paraesthesia
- pharyngitis
- anorexia
- vomiting
- oral thrush
- stomatitis.Potentially Fatal: Hepatotoxicity.
Drug Interactions
Cholestyramine and activated charcoal can lower the amount of active drug in the blood. Using methotrexate with other drugs that can harm the liver may raise the risk of liver damage. Rifampicin can increase the level of the active drug in the blood.
Serious Warning: This medicine may make side effects from live vaccines worse and could be dangerous.
Contraindications
Serious liver problems, weakened immune system (including bone marrow disorders or severe, uncontrolled infections), and taking live vaccines at the same time. Not recommended during pregnancy or breastfeeding.
Mode of actions
Leflunomide is a medicine that modifies the immune system and is used to treat diseases like rheumatoid arthritis. It works by blocking an enzyme called dihydroorotate dehydrogenase, which is needed to make certain building blocks for cells (pyrimidines). This action helps slow down the growth of certain immune cells and reduces inflammation.
Dosage & Administration
Adult: PO Rheumatoid arthritis; Psoriatic arthritis: Loading dose of 100 mg once daily for 3 days, the maintenance dose is 20 mg once daily. Leflunomide does not require stepwise dose increment over time. The dose may be decreased to 10 mg daily if tolerability issues arise.
Pregnancy & Lactation
This medicine must not be used during pregnancy. It can be absorbed through the skin and lungs caused can damage your unborn child’s organs and cause congenital disabilities. Strict two effective types of birth control starting one month before and during treatment and for three years after stopping this medicine. Discuss with your doctors if you are not sure which types of birth control are effective for you. You must need to take pregnancy tests regularly during your treatment with this medicine and for at least three years after taking this medicine. If it seems that you do become pregnant stop taking this medicine and call your doctor immediately. If you really become pregnant, miss a menstrual period, or have sex without using two forms of birth control. In some cases, your doctor can prescribe emergency contraception to prevent pregnancy. People on this medicine should not donate blood during the treatment and for three years afterward.
This medicine is also contraindicated breast milk. Breastfeeding is not recommended while using this medication and for three years afterward.
Pack Size & Price
50's pack Price : ৳
Similar medicine
Manufactured by: Incepta Pharmaceuticals Ltd.
Manufactured by: Incepta Pharmaceuticals Ltd.
Manufactured by: Incepta Pharmaceuticals Ltd.
Manufactured by: ACI Limited
Manufactured by: ACI Limited
Manufactured by: General Pharmaceuticals Ltd.
Click here to see 1 more similar medicines
There are few similar medicines of Arolef are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.
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