Amikin 100mg/2ml (Injection)
Manufactured by: Incepta Pharmaceuticals Ltd.
Amikacin Similar medicine
Amikin is indicated for
- Tuberculose
- Infecções complicadas e recorrentes do trato urinário
- Infecções graves por Gram-negativos
- Infecções micobacterianas não tuberculosas
- Septicemia bacteriana
- Infecções do trato respiratório
- Ossos e articulações
- Sistema nervoso central e pele e tecidos moles
- Infecções intra-abdominais
- Queimaduras
- Infecções pós-operatórias
- Meningite
- Peritonite
- Sepse neonatal
Precautions and warnings
Vertigem e zumbido são sintomas de insuficiência renal. Se você observar sinais de ototoxicidade, neurotoxicidade ou hipersensibilidade, pare de tomá-lo; se você estiver amamentando, pare de usá-lo. O período de tratamento de pelo menos 14 dias não foi comprovado como seguro. Antes e durante a terapia, fique de olho na função renal.
Side-effects
- Zumbido
- vertigem; ataxia e surdez evidente. Potencialmente Fatal: Ototoxicidade
- nefrotoxicidade
- bloqueio neuromuscular.
Drug Interactions
Quando tomada concomitantemente, a anfotericina B pode causar nefrotoxicidade e limitar a depuração da amicacina.
Possivelmente letal: Outros medicamentos nefrotóxicos ou ototóxicos têm efeitos ototóxicos ou nefrotóxicos aumentados. Medicamentos bloqueadores neuromusculares melhoram o bloqueio neuromuscular. Diuréticos potentes aumentam o risco de ototoxicidade.
Contraindications
Gravidez, tímpano perfurado, miastenia gravis, hipersensibilidade.
Mode of actions
A amicacina liga-se às subunidades ribossomais 30S de bactérias susceptíveis, inibindo assim a sua síntese proteica.
Dosage & Administration
Parenteral
Infecções urinárias não complicadas
Adulto: 250 mg duas vezes ao dia, administrados por via IM, injeção intravenosa durante 2-3 minutos ou como infusão intravenosa.
Infecções graves por Gram-negativos resistentes à gentamicina e tobramicina
Adulto: 15 mg/kg por dia em doses igualmente divididas, injetadas a cada 8 ou 12 horas durante 7 a 10 dias. Máx.: Até 500 mg a cada 8 horas em infecções potencialmente fatais. Dose cumulativa máxima: 15 g. As doses podem ser administradas por via IM, injeção intravenosa lenta durante 2-3 minutos ou infusão intravenosa.
Criança: 15 mg/kg por dia em doses divididas igualmente, injetadas a cada 8 ou 12 horas durante 7 a 10 dias. Recém-nascidos: 10 mg/kg diariamente em 2 doses divididas.
Função renal prejudicada: Em pacientes com função renal comprometida a dose diária deve ser reduzida e/ou os intervalos entre as doses aumentados para evitar acúmulo do medicamento. O esquema de doses simples para insuficiência renal é fornecido abaixo:
Função renal Cronograma de dosagem
Comprometimento leve 500 mg a cada 18 horas
Comprometimento moderado 500 mg a cada 24 horas
Insuficiência grave 250 mg a cada 24 horas.
Pregnancy & Lactation
Este medicamento não é permitido durante a gravidez. Não use se estiver grávida. Pode ser absorvido pela pele e pelos pulmões, podendo danificar os órgãos do feto e causar deficiências congênitas. Controle de natalidade rigoroso e eficaz durante o tratamento e por seis meses após a interrupção do medicamento. Se engravidar, pare de tomar este medicamento e fale com o seu médico imediatamente.
Não há informações específicas sobre se este medicamento passa ou não para o leite materno. Considerando os possíveis riscos para as crianças, não é recomendada a amamentação durante o uso deste medicamento e pelo menos duas semanas após a última dose. Consulte seu médico antes de amamentar.
Pack Size & Price
10 amps pack Price : ৳160
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