Efrad 250mg (Capsule)
Manufactured by: Edruc Ltd.
Cephradine Similar medicine
Efrad is indicated for
- 肺炎、咽喉炎、敏感感染、中耳炎、皮膚及皮膚結構感染、風濕熱、扁桃體炎、呼吸道感染、泌尿道感染、手術預防、泌尿生殖道感染、急性攝護腺炎
Precautions and warnings
有青黴素過敏史、腎功能不全的患者、孕婦和母乳哺育的母親應特別注意。
Side-effects
- 腹瀉、噁心、嘔吐；白血球減少症，嗜中性白血球減少症，嗜酸性粒細胞增多症，皮疹，搔癢症;關節疼痛； BUN 和肌酸增加；頭暈。 可能致命：偽膜性結腸炎。
Drug Interactions
袢利尿劑會增加腎毒性的風險。 使用丙磺舒時，腎臟清除率會降低。
當氨基糖苷類等腎毒性藥物與頭孢拉定一起服用時，腎損傷的風險會增加。 利尿劑如呋塞米、依他尼酸和丙磺舒會增加腎毒性。
Contraindications
卟啉症和對頭孢拉定或其他頭孢菌素活性成分過敏。
Mode of actions
頭孢拉定是第一代頭孢菌素，透過與一個或多個青黴素結合蛋白 (PBP) 結合，阻止細菌細胞壁中肽聚醣產生的最後轉肽步驟，從而停止細胞壁合成並導致細菌細胞死亡。
Dosage & Administration
成人：PO 敏感感染 1-2 g/天，分 2-4 次服用。 最大：4 克/天。
IV/IM 嚴重感染 2-4 g/天，分次服用。 最大：8 克/天。
手術預防 術前 1-2 g。 可依需求給予後續劑量。
皮膚和皮膚結構以及呼吸道感染：常用劑量為每6小時250毫克或每12小時500毫克。
大葉性肺炎：每 6 小時 500 mg 或每 12 小時 1 gm。
泌尿道感染：常用劑量為每12小時500毫克。
胃腸道感染：500mg，每日三至四次。
兒童：口服：通常的總劑量為 25 至 50 mg/kg/天，分 2 至 4 次等分劑量給藥。
注射：50至100mg/kg/天，分4次等分劑量。 通常的總劑量可增加至 200-300 mg/kg/天。
圍手術期預防：建議劑量為1-2克，肌肉注射或靜脈注射；隨後酌情給予胃腸外或口服劑量。
腎功能不全：對於接受慢性間歇性血液透析的患者：可以在療程開始時給予250毫克，在6-12小時後重複，然後在初始劑量後36-48小時再次給予，如果自上次劑量以來已過去>30小時，則在下一次血液透析開始時再次給予。
CrCl (毫升/分鐘)
每 6 小時 >20 500 毫克。
每 6 小時 5-20 250 毫克。
Pregnancy & Lactation
雖然動物生殖研究顯示出不良影響，甚至有時無法證明對胎兒的風險，並且在孕婦中沒有充分和良好對照的研究，但在懷孕期間，這種藥物可以在確實需要時使用。
與您的醫生討論並告訴他們有關該藥物的意見。
目前還沒有關於這種藥物是否透過母乳傳染給嬰兒的具體資訊。 哺乳前請與您的醫師討論。
Pack Size & Price
20's pack Price : ৳130
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