Amlozep 5/10 (Capsule)
Manufactured by: Beacon Pharmaceuticals Ltd.
Amlodipine + Benazepril Hydrochloride Similar medicine
Amlozep 5/10 is indicated for
- Hipertensi
Precautions and warnings
Jika kehamilan terdeteksi, hentikan penggunaan Amlodipine+Benazepril sesegera mungkin. Perhatian dianjurkan pada orang lanjut usia, penderita gangguan ginjal atau hati, penderita gagal jantung kongestif, penderita stenosis aorta berat, penderita stenosis arteri ginjal unilateral atau bilateral, dan penderita yang sedang menjalani pembedahan atau anestesi. Hipotensi simtomatik dapat disebabkan oleh kombinasi amlodipine dan benazepril, terutama pada individu dengan penurunan garam/volume. ACE inhibitor (ACEi) telah dikaitkan dengan penyakit kuning kolestatik dan nekrosis hati fulminan; jika pasien mengalami penyakit kuning atau peningkatan enzim hati yang signifikan, hentikan pengobatan. Fungsi ginjal dan kadar kalium dalam darah harus diperiksa secara rutin. Pada individu yang diobati dengan ACEi, angioedema pada wajah, ekstremitas, bibir, lidah, glotis, laring, dan angioedema usus telah dijelaskan. Seperti semua penghambat ACE, obat ini dapat menyebabkan batuk kering kronis. Keamanan dan kemanjuran obat pada anak-anak belum ditentukan.
Side-effects
- Batuk
- edema (termasuk edema dependen
- angioedema
- edema wajah
- edema perifer)
- sakit kepala
- pusing
- muka memerah
- mulut kering
- mual
- diare
- konstipasi
- asthenia
- kelelahan
- hiperkalemia
- hipotensi
- hipotensi ortostatik
- nyeri muskuloskeletal
- ruam kulit
- insomnia
- kecemasan
- penurunan libido
- penyakit ginjal akut
- jantung berdebar
- angina pektoris
- bradikardia
- nyeri dada
- penyakit kuning
- peningkatan enzim hati
- peningkatan kreatinin dan BUN
- anemia hemolitik
- neutropenia
- trombositopenia
- pankreatitis
- pemfigus. Berpotensi Fatal: Reaksi analfilaktoid
- angioedema
- sindrom Stevens-Johnson.
Drug Interactions
Bila digunakan dengan obat-obatan yang mengurangi katekolamin, terdapat risiko hipotensi dan/atau bradikardia yang signifikan. Untuk menghindari rebound hipertensi, clonidine harus dihentikan beberapa hari setelah beta-blocker dihentikan; jika mengganti clonidine dengan beta-blocker, beta-blocker harus dimulai hanya setelah clonidine dihentikan selama beberapa hari. Penggunaan bersamaan dengan inhibitor prostaglandin sintase (seperti indometasin) dapat mengurangi efek hipotensi beta-blocker.
Contraindications
Pasien dengan riwayat angioedema, serta wanita hamil dan menyusui.
Mode of actions
Amlodipine adalah antagonis kalsium yang merupakan dihydropyridine. Melalui penekanan masuknya ion Ca transmembran ke dalam otot polos pembuluh darah dan otot jantung, hal ini menurunkan tekanan darah dengan merelaksasi otot polos pembuluh darah koroner dan menyebabkan vasodilatasi koroner. Ini juga merupakan vasodilator untuk arteri perifer. Benazepril dan metabolit aktifnya benazeprilat memblokir ACE, mengakibatkan penurunan kadar angiotensin II plasma dan, akibatnya, penurunan sekresi aldosteron.
Dosage & Administration
Dewasa: PO Per tutup kombinasi mengandung Amlodipine 2,5-10 mg dan benazepril 10-40 mg: Komponen Amlodipine: 2,5-10 mg sekali sehari; komponen benazepril: 10-40 mg sekali sehari.
Pregnancy & Lactation
Meskipun penelitian pada reproduksi hewan menunjukkan efek buruk pada janin dan belum ada penelitian yang memadai dan terkontrol dengan baik pada wanita hamil, namun selama kehamilan, obat ini dapat digunakan tepat ketika benar-benar diperlukan meskipun ada potensi risikonya.
Penelitian lain menunjukkan bahwa obat ini tidak diperbolehkan selama kehamilan. Jangan gunakan jika Anda sedang hamil. Dapat diserap melalui kulit dan paru-paru sehingga dapat merusak organ tubuh anak Anda yang belum lahir dan menyebabkan cacat bawaan. Alat kontrasepsi yang efektif dan ketat selama pengobatan dan selama enam bulan setelah menghentikan obat ini. Jika Anda hamil, hentikan penggunaan obat ini dan segera diskusikan dengan dokter Anda.
Belum ada informasi spesifik apakah obat ini masuk ke dalam ASI atau tidak. Mengingat kemungkinan risiko pada anak-anak, menyusui saat menggunakan obat ini tidak dianjurkan dan setidaknya dua minggu setelah dosis terakhir. Konsultasikan dengan dokter Anda sebelum menyusui.
Pack Size & Price
30's pack Price : ৳180
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There are few similar medicines of Amlozep 5/10 are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.
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