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Frusin Plus 40 (Tablet)

Manufactured by: Opsonin Pharma Limited

Frusemide + Spironolactone Similar medicine

Frusin Plus 40 is indicated for

  • Hypertension
  • Congestive heart failure
  • Oedema
  • Ascites

Precautions and warnings

This medicine treats fluid retention in the body. However, before taking these medications, there are certain precautions that you should keep in mind. Here are some of them:

Inform your doctor about any existing medical conditions: Before taking Frusemide and Spironolactone, you should inform your doctor about any existing medical conditions you may have, such as kidney or liver problems, diabetes, gout, or electrolyte imbalances. This is important because these medications can interact with certain conditions and make them worse.

Inform your doctor about any other medications you are taking: You should inform your doctor about any other medications you are taking, including prescription medications, over-the-counter medications, vitamins, and herbal supplements. This is important because Frusemide and Spironolactone can interact with other medications and cause side effects.

Follow the dosing instructions: You should follow the dosing instructions provided by your doctor or pharmacist. Do not take more or less than the prescribed dose, and do not take it more frequently than prescribed.

Monitor your blood pressure and electrolyte levels: Frusemide and Spironolactone can affect your blood pressure and electrolyte levels. Therefore, you should monitor your blood pressure and electrolyte levels regularly while taking these medications.

Avoid alcohol: You should avoid alcohol while taking Frusemide and Spironolactone, as it can increase the risk of side effects such as dizziness and lightheadedness.

Drink enough water: These medications can cause dehydration, so it is important to drink enough water to stay hydrated.

Report any side effects: If you experience any side effects while taking Frusemide and Spironolactone, such as dizziness, lightheadedness, dry mouth, or muscle cramps, you should report them to your doctor immediately.

It is always important to consult your doctor or pharmacist before taking any medication and to follow their instructions carefully.

Side-effects

  • Fluid
  • electrolyte imbalance
  • nausea
  • diarrhoea
  • blurred vision
  • headache
  • dizziness
  • hypotension
  • photosensitisation
  • hepatic dysfunction
  • hyperglycaemia
  • glycosuria
  • rarely bone marrow depression
  • gynaecomastia
  • hirsutism
  • hoarseness
  • menstrual irregularities
  • loss of libido
  • impotence
  • Potentially Fatal: Severe hyperkalaemia in patients with preexisting renal impairment or taking ACE inhibitors
  • agranulocytosis
  • cardiac arrhythmias.

Drug Interactions

There are some potential interactions between these medications that should be considered. Here are some of the interactions that may occur with Frusemide + Spironolactone:

Electrolyte imbalances: Both Frusemide and Spironolactone can cause electrolyte imbalances, particularly hypokalemia (low potassium levels) and hyponatremia (low sodium levels). When used together, the risk of electrolyte imbalances may be increased. Your healthcare provider may monitor your electrolyte levels while taking these medications.

Dehydration: Frusemide and Spironolactone can cause dehydration due to their diuretic effects. When used together, the risk of dehydration may be increased. It is important to stay hydrated and consume adequate amounts of fluids while taking these medications.

Renal function: Both Frusemide and Spironolactone are metabolized in the kidneys and may cause renal impairment. When used together, they may further impair kidney function, particularly in individuals with pre-existing renal impairment.

Drug interactions: Frusemide and Spironolactone may interact with other medications you are taking. For example, nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the effectiveness of diuretics, including Frusemide. Additionally, other medications that can cause electrolyte imbalances or renal impairment may interact with Frusemide and Spironolactone.

Other interactions: Frusemide and Spironolactone may interact with certain foods or supplements. For example, consuming foods high in potassium or taking potassium supplements while on Spironolactone may increase the risk of hyperkalemia (high potassium levels).

It is important to discuss all medications, supplements, and foods with your healthcare provider before taking Frusemide and Spironolactone to minimize the risk of interactions. They may adjust the dosage or monitor your health more closely while taking these medications.

Contraindications

However, there are certain conditions where the use of these medications together may be contraindicated. Here are some of the contraindications for Frusemide + Spironolactone:

Hypersensitivity or allergy: If you have a known hypersensitivity or allergy to Frusemide, Spironolactone, or any of their components, you should not take this medication combination.

Anuria: Anuria is a condition where there is a lack of urine production. If you have anuria, you should not take Frusemide and Spironolactone, as these medications are diuretics that increase urine output.

Hyperkalemia: Hyperkalemia is a condition where there is an abnormally high level of potassium in the blood. Spironolactone is a medication that can increase potassium levels in the blood, so it should not be taken if you have hyperkalemia.

Severe renal impairment: Frusemide and Spironolactone are metabolized in the kidneys and excreted in the urine. If you have severe renal impairment, these medications may not be suitable for you.

Addison's disease: Addison's disease is a condition where there is a deficiency of cortisol and aldosterone hormones. Spironolactone is an aldosterone antagonist and may exacerbate the symptoms of Addison's disease.

Pregnancy and breastfeeding: Frusemide and Spironolactone should not be taken during pregnancy and breastfeeding unless explicitly instructed by a healthcare professional.

Mode of actions

Frusemide:

Frusemide is a loop diuretic that works by inhibiting the Na+/K+/2Cl- cotransporter in the thick ascending limb of the loop of Henle in the kidney. This leads to a decrease in the reabsorption of sodium, chloride, and water, and an increase in their excretion in the urine. This mechanism of action results in increased urine output and a decrease in fluid accumulation in the body. Frusemide is rapidly absorbed after oral administration, with peak plasma concentrations reached within 1-2 hours. Its effects last for about 6 hours, and it is metabolized in the liver and excreted in the urine.

Spironolactone:

Spironolactone is a potassium-sparing diuretic that works by inhibiting the binding of aldosterone to its receptor in the distal tubule of the kidney. Aldosterone is a hormone that promotes the reabsorption of sodium and the excretion of potassium in the kidney. By blocking the aldosterone receptor, spironolactone increases the excretion of sodium and water, while decreasing the excretion of potassium. This mechanism of action results in increased urine output and a decrease in fluid accumulation in the body. Spironolactone is well-absorbed after oral administration, with peak plasma concentrations reached within 2-3 hours. Its effects last for about 24 hours, and it is metabolized in the liver and excreted in the urine.

When these two medications are prescribed together, they work synergistically to promote diuresis and reduce fluid accumulation in the body. Frusemide and Spironolactone have different mechanisms of action and are used together to minimize the risk of electrolyte imbalances and adverse effects that may occur when used alone.

Dosage & Administration

Adult: Per tab contains furosemide 20 mg and spironolactone 50 mg. 1-4 tabs/day.

Pregnancy & Lactation

Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.

Another study shows that this medicine is not allowed during pregnancy. Do not use it if you are pregnant. It can be absorbed through the skin and lungs caused can damage your unborn child’s organs and cause congenital disabilities. Strict effective birth control during treatment and for six months after stopping this medicine. If you do become pregnant, stop taking this medicine and discuss your doctor right away.

There is no specific information on whether this medicine passes into breast milk or not. Considering the possible risks for the children, breastfeeding while using this medicine is not recommended and at least two weeks after the last dose. Consult your doctor before breastfeeding.

Pack Size & Price

30's pack Price : ৳240

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