Frusin Plus 40 (Tablet)
Manufactured by: Opsonin Pharma Limited
Frusemide + Spironolactone Similar medicine
Frusin Plus 40 is indicated for
- 高血壓、充血性心臟衰竭、水腫、腹水
Precautions and warnings
這種藥可以治療體內的液體滯留。 然而，在服用這些藥物之前，您應該記住一些預防措施。 以下是其中一些：
告知您的醫生任何現有的醫療狀況：在服用呋塞米和螺內酯之前，您應該告知您的醫生您可能患有的任何現有的醫療狀況，例如腎臟或肝臟問題、糖尿病、痛風或電解質失衡。 這很重要，因為這些藥物可能會與某些病症相互作用並使病情變得更糟。
告知您的醫生您正在服用的任何其他藥物：您應該告知您的醫生您正在服用的任何其他藥物，包括處方藥、非處方藥、維生素和草藥補充劑。 這很重要，因為呋塞米和螺內酯會與其他藥物相互作用並引起副作用。
遵循劑量說明：您應該遵循醫生或藥劑師提供的劑量說明。 不要服用超過或少於規定的劑量，也不要比規定的頻率更頻繁地服用。
監測您的血壓和電解質水平：呋塞米和螺內酯會影響您的血壓和電解質水平。 因此，在服用這些藥物時，您應該定期監測血壓和電解質水平。
避免飲酒：服用呋塞米和螺內酯時應避免飲酒，因為它會增加頭暈和頭暈等副作用的風險。
喝足夠的水：這些藥物可能會導致脫水，因此喝足夠的水以保持水分很重要。
報告任何副作用：如果您在服用呋塞米和螺內酯期間出現任何副作用，例如頭暈、頭暈、口乾或肌肉痙攣，應立即向醫生報告。
在服用任何藥物之前諮詢您的醫生或藥劑師並仔細遵循他們的指示始終很重要。
Side-effects
- 液體和電解質失衡、噁心、腹瀉、視力模糊、頭痛、頭暈、低血壓、光敏性、肝功能障礙、高血糖和糖尿，罕見骨髓抑制、男性女乳症、多毛症、聲音沙啞、月經不規則、性慾減退、陽痿、 可能致命：患有腎功能不全或服用ACE抑制劑、粒細胞缺乏症、心律不整的患者出現嚴重高血鉀症。
Drug Interactions
應考慮這些藥物之間存在一些潛在的相互作用。以下是呋塞米 + 安體舒通可能發生的一些交互作用：
電解質失衡：呋塞米和螺內酯均可導致電解質失衡，特別是低血鉀（低鉀水平）和低鈉血症（低鈉水平）。一起使用時，電解質失衡的風險可能會增加。您的醫療保健提供者可能會在服用這些藥物時監測您的電解質水平。
脫水：呋塞米和螺內酯具有利尿作用，可導致脫水。一起使用時，脫水的風險可能會增加。服用這些藥物時保持水分並攝取足夠的液體非常重要。
腎功能：呋塞米和螺內酯均在腎臟代謝，可能導致腎功能損害。一起使用時，它們可能會進一步損害腎功能，特別是對於已有腎功能損害的個體。
藥物交互作用：呋塞米和螺內酯可能會與您正在服用的其他藥物產生交互作用。例如，非類固醇類抗發炎藥 (NSAID) 可能會降低利尿劑（包括呋塞米）的有效性。此外，其他可能導致電解質失衡或腎功能損害的藥物可能會與呋塞米和螺內酯相互作用。
其他交互作用：呋塞米和螺內酯可能與某些食物或補充劑相互作用。例如，在服用螺內酯期間食用高鉀食物或服用鉀補充劑可能會增加高血鉀（高鉀水平）的風險。
在服用呋塞米和螺內酯之前，與您的醫療保健提供者討論所有藥物、補充劑和食物非常重要，以盡量減少相互作用的風險。他們可能會在服用這些藥物時調整劑量或更密切地監測您的健康狀況。
Contraindications
然而，在某些情況下可能會禁止同時使用這些藥物。 以下是呋塞米+螺內酯的一些禁忌症：
超敏反應或過敏：如果您已知對呋塞米、螺內酯或其任何成分有超敏反應或過敏，則不應服用此藥物組合。
無尿症：無尿症是指尿液產生不足的情況。 如果您有無尿，則不應服用呋塞米和螺內酯，因為這些藥物是利尿劑，會增加尿量。
高血鉀：高血鉀症是血液中鉀含量異常高的一種病症。 螺內酯是一種可以增加血液中鉀含量的藥物，因此如果您患有高血鉀症，則不應服用該藥物。
嚴重腎功能不全：呋塞米和螺內酯在腎臟代謝並經由尿液排泄。 如果您有嚴重的腎功能損害，這些藥物可能不適合您。
艾迪生病：艾迪生病是一種皮質醇和醛固酮激素缺乏的疾病。 螺內酯是一種醛固酮拮抗劑，可能會加劇阿狄森氏症的症狀。
懷孕和哺乳：除非醫療保健專業人員明確指示，否則懷孕和哺乳期間不應服用呋塞米和螺內酯。
Mode of actions
呋塞米：
呋塞米是一種袢利尿劑，透過抑制腎臟亨利袢厚升支中的 Na+/K+/2Cl- 協同轉運蛋白發揮作用。 這導致鈉、氯和水的重吸收減少，並增加尿液中的排泄。 這種作用機轉會導致尿量增加和體內積液減少。 口服後速尿吸收迅速，1-2小時內達到血中濃度高峰。 其作用持續約6小時，在肝臟代謝並從尿液排出。
螺內酯：
螺內酯是一種保鉀利尿劑，透過抑制醛固酮與其在腎臟遠端小管中的受體的結合來發揮作用。 醛固酮是一種促進腎臟鈉重吸收和鉀排泄的荷爾蒙。 透過阻斷醛固酮受體，螺內酯增加鈉和水的排泄，同時減少鉀的排泄。 這種作用機轉會導致尿量增加和體內積液減少。 螺內酯口服後吸收良好，2-3小時內達到血中濃度高峰。 其作用持續約24小時，在肝臟代謝並從尿液中排出。
當這兩種藥物一起服用時，它們會協同作用，促進利尿並減少體內的液體積聚。 呋塞米和螺內酯具有不同的作用機制，一起使用可以最大限度地減少單獨使用時可能出現的電解質失衡和不良反應的風險。
Dosage & Administration
成人：每片含呋塞米 20 毫克和螺內酯 50 毫克。 1-4 片/天。
Pregnancy & Lactation
儘管動物生殖研究顯示對胎兒有不良影響，並且在孕婦中沒有充分且良好對照的研究，但在懷孕期間，儘管存在潛在風險，但在確實需要時可以使用該藥物。
另一項研究表明，懷孕期間不允許使用這種藥物。 如果您懷孕了，請勿使用它。 它可以透過皮膚和肺部吸收，從而損害未出生孩子的器官並導致先天性殘疾。 治療期間及停藥後六個月內嚴格有效的節育。 如果您確實懷孕了，請停止服用此藥並立即與您的醫生討論。
沒有關於這種藥物是否會進入母乳的具體資訊。 考慮到兒童可能存在的風險，不建議在使用該藥物時進行母乳喂養，並且至少在最後一次用藥後兩週進行母乳喂養。 哺乳前請先諮詢您的醫生。
Pack Size & Price
30's pack Price : ৳240
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