Indomet 100mg (Suppository)
Manufactured by: Opsonin Pharma Limited
Indomethacin Similar medicine
Indomet is indicated for
- Artritis reumatoid
- ankylosing spondylitis
- dan osteoartritis (penyakit sendi degeneratif)
- asam urat
- rematik non-artikular akut (bursitis
- sinovitis
- tendinitis).
Precautions and warnings
Obat ini harus digunakan dengan hati-hati pada pasien yang memiliki penyakit jantung atau faktor risiko gangguan jantung, retensi cairan, riwayat masalah lambung (seperti pendarahan atau maag), kondisi kesehatan mental (seperti depresi atau gangguan kejiwaan lainnya), epilepsi, atau penyakit Parkinson. Obat ini juga harus digunakan dengan hati-hati pada orang dengan infeksi yang terkendali, karena dapat menyembunyikan tanda dan gejala infeksi. Perawatan khusus diperlukan bagi pasien dengan masalah hati atau ginjal, orang lanjut usia, anak-anak, dan wanita yang sedang hamil atau menyusui.
Side-effects
- Sakit kepala
- biasanya di pagi hari dan vertigo ringan dapat terjadi pada minggu-minggu awal terapi. Gejala-gejala ini bersifat sementara dan biasanya hilang dengan penggunaan terus menerus atau dengan pengurangan dosis. Reaksi gastrointestinal seperti mual
- muntah
- diare
- nyeri epigastrik dan perut sering kali disebabkan oleh penggunaan obat dalam dosis besar dan hilang bila dosisnya dikurangi.
Drug Interactions
Indometasin dapat meningkatkan kadar metotreksat dalam darah. Ada risiko pendarahan lambung dan usus yang lebih tinggi jika indometasin dikonsumsi bersama warfarin. Hal ini mungkin membuat obat tekanan darah seperti hydralazine, furosemide, beta-blocker (seperti atenolol, propranolol, oxprenolol), atau diuretik thiazide menjadi kurang efektif. Kemungkinan tingginya kalium dalam darah meningkat bila digunakan dengan diuretik hemat kalium, penghambat ACE, atau suplemen kalium. Indometasin juga dapat meningkatkan kerusakan ginjal jika dikonsumsi dengan ciclosporin atau triamterene. Probenecid dapat meningkatkan kadar indometasin dalam darah. Pada bayi baru lahir prematur, obat ini dapat meningkatkan kadar aminoglikosida (seperti amikasin atau gentamisin). Mengonsumsi indometasin dengan haloperidol dapat menyebabkan efek samping obat antipsikotik yang lebih kuat, seperti kantuk parah dan kebingungan. Antasida yang mengandung aluminium atau magnesium dapat membantu mengurangi masalah lambung akibat indometasin.
**Peringatan (Berpotensi Fatal):** Diflunisal dapat menurunkan pembersihan ginjal dan meningkatkan kadar indometasin, yang dapat menyebabkan pendarahan lambung atau usus yang mematikan.
Contraindications
Indometasin tidak boleh digunakan pada orang yang sedang menderita maag, maag, atau kolitis ulserativa aktif. Hal ini juga harus dihindari jika seseorang pernah memiliki reaksi alergi terhadapnya. Jika seseorang pernah mengalami masalah perut atau usus di masa lalu, indometasin harus digunakan dengan hati-hati.
Mode of actions
Indometasin merupakan salah satu jenis obat yang termasuk dalam golongan asam indol asetat. Ini membantu mengurangi peradangan, menghilangkan rasa sakit, dan menurunkan demam. Ia bekerja dengan memblokir enzim siklooksigenase-1 dan -2 (COX-1 dan COX-2), yang menyebabkan berkurangnya produksi prostaglandin, zat yang menyebabkan peradangan dan nyeri.
Dosage & Administration
Melalui mulut, penyakit rematik, 50-200 mg setiap hari dalam dosis terbagi, sesudah makan. Asam urat akut, 150-200 mg setiap hari dalam dosis terbagi. Dismenore, hingga 75 mg setiap hari.
Anak-anak: Tidak disarankan
Rektal
Nyeri dan peradangan berhubungan dengan gangguan muskuloskeletal dan sendi
Dewasa: Sebagai supp: 100 mg untuk diberikan pada malam hari dan diulangi pada pagi hari bila perlu.
Pregnancy & Lactation
Obat ini tidak diperbolehkan selama kehamilan. Jangan gunakan jika Anda sedang hamil. Dapat diserap melalui kulit dan paru-paru sehingga dapat merusak organ tubuh anak Anda yang belum lahir dan menyebabkan cacat bawaan. Alat kontrasepsi yang efektif dan ketat selama pengobatan dan selama enam bulan setelah menghentikan obat ini. Jika Anda hamil, hentikan penggunaan obat ini dan segera diskusikan dengan dokter Anda.
Belum ada informasi spesifik apakah obat ini masuk ke dalam ASI atau tidak. Mengingat kemungkinan risiko pada anak-anak, menyusui saat menggunakan obat ini tidak dianjurkan dan setidaknya dua minggu setelah dosis terakhir. Konsultasikan dengan dokter Anda sebelum menyusui.
Pack Size & Price
25's pack Price : ৳175
Similar medicine
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