Sephar DS 250mg/5ml (Powder for Suspension)
Manufactured by: RAK Pharmaceuticals Ltd.
Cephradine Similar medicine
Sephar DS is indicated for
- Neumonía
- Faringitis
- Infecciones susceptibles
- Otitis media
- Infecciones de la piel y de las estructuras de la piel
- Fiebre reumática
- Amigdalitis
- Infecciones del tracto respiratorio
- Infecciones del tracto urinario
- Profilaxis quirúrgica
- Infecciones del tracto genitourinario
- Prostatitis aguda
Precautions and warnings
Se debe prestar especial atención a los pacientes con antecedentes de sensibilidad a la penicilina, insuficiencia renal, mujeres embarazadas y madres que alimentan a sus bebés con leche materna.
Side-effects
- Diarrea
- náuseas
- vómitos; leucopenia
- neutropenia
- eosinofilia
- erupción cutánea
- prurito; dolor en las articulaciones; aumento de BUN y creatina; mareo. Potencialmente fatal: colitis pseudomembranosa.
Drug Interactions
Los diuréticos de asa aumentan el riesgo de nefrotoxicidad. El aclaramiento renal se reduce cuando se utiliza probenecid.
Cuando se toman medicamentos nefrotóxicos como aminoglucósidos con cefradina, aumenta el riesgo de daño renal. La toxicidad renal aumentó con diuréticos como furosemida, ácido etacrínico y probenecid.
Contraindications
Porfiria e hipersensibilidad al ingrediente activo de cefradina u otras cefalosporinas.
Mode of actions
La cefradina es una cefalosporina de primera generación que bloquea el último paso de transpeptidación de la producción de peptidoglicano en la pared celular bacteriana al unirse a una o más proteínas fijadoras de penicilina (PBP), deteniendo la síntesis de la pared celular y provocando la muerte celular bacteriana.
Dosage & Administration
Adultos: VO Infecciones susceptibles 1-2 g/día en 2-4 dosis divididas. Máximo: 4 g/día.
IV/IM Infecciones graves 2-4 g/día en dosis divididas. Máximo: 8 g/día.
Profilaxis quirúrgica 1-2 g preoperatorio. Se pueden administrar dosis posteriores según sea necesario.
Piel y estructuras cutáneas e infección del tracto respiratorio: La dosis habitual es de 250 mg cada 6 horas o 500 mg cada 12 horas.
Neumonía lobular: 500 mg cada 6 horas o 1 g cada 12 horas.
Infección del tracto urinario: la dosis habitual es de 500 mg cada 12 horas.
Infección del tracto gastrointestinal: 500 mg tres o cuatro veces al día.
Niños: Oral: La dosis total habitual es de 25 a 50 mg/kg/día administrada en 2 a 4 dosis divididas igualmente.
Inyección: 50 a 100 mg/kg/día en 4 dosis divididas en partes iguales. La dosis total habitual puede aumentarse hasta 200-300 mg/kg/día.
Profilaxis perioperatoria: la dosis recomendada es de 1 a 2 g por vía intramuscular o intravenosa; Se administran dosis parenterales u orales posteriores según corresponda.
Insuficiencia renal: Para pacientes sometidos a hemodiálisis crónica intermitente: se pueden administrar 250 mg al inicio de la sesión, repetir después de 6 a 12 horas, luego nuevamente 36 a 48 horas después de la dosis inicial y nuevamente al inicio de la siguiente hemodiálisis si han transcurrido >30 horas desde la dosis anterior.
ClCr (ml/min)
>20 500 mg cada 6 h.
5-20 250 mg cada 6 h.
Pregnancy & Lactation
Aunque los estudios de reproducción en animales han demostrado un efecto adverso, incluso a veces no pueden demostrar el riesgo para el feto y no existen estudios adecuados y bien controlados en mujeres embarazadas, durante el embarazo este medicamento se puede utilizar sólo cuando sea definitivamente necesario.
Hable con sus médicos y cuénteles sus comentarios sobre este medicamento.
No existe información específica sobre si este medicamento se transmite al bebé a través de la leche materna. Hable con su médico antes de amamantar.
Pack Size & Price
100ml bot Price : ৳120
Similar medicine
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