Sephar DS 250mg/5ml (Powder for Suspension)
Manufactured by: RAK Pharmaceuticals Ltd.
Cephradine Similar medicine
Sephar DS is indicated for
- Pneumonie
- pharyngite
- infections sensibles
- otite moyenne
- infections de la peau et des structures cutanées
- rhumatisme articulaire aigu
- amygdalite
- infections des voies respiratoires
- infections des voies urinaires
- prophylaxie chirurgicale
- infections des voies génito-urinaires
- prostatite aiguë
Precautions and warnings
Les patients ayant des antécédents de sensibilité à la pénicilline, d'insuffisance rénale, les femmes enceintes et les mères qui nourrissent leur bébé au lait maternel doivent faire l'objet d'une attention particulière.
Side-effects
- Diarrhée
- nausées
- vomissements ; leucopénie
- neutropénie
- éosinophilie
- éruption cutanée
- prurit ; douleurs articulaires; augmentation du BUN et de la créatine ; vertiges. Potentiellement mortel : Colite pseudomembraneuse.
Drug Interactions
Les diurétiques de l'anse augmentent le risque de néphrotoxicité. La clairance rénale est réduite lorsque le probénécide est utilisé.
Lorsque des médicaments néphrotoxiques comme les aminosides sont pris avec la céfradine, le risque de lésions rénales augmente. La toxicité rénale a été augmentée par les diurétiques tels que le frusémide, l'acide éthacrynique et le probénécide.
Contraindications
Porphyrie et hypersensibilité au principe actif de la céfradine ou à d'autres céphalosporines.
Mode of actions
La céfradine est une céphalosporine de première génération qui bloque la dernière étape de transpeptidation de la production de peptidoglycane dans la paroi cellulaire bactérienne en se liant à une ou plusieurs protéines liant la pénicilline (PBP), interrompant ainsi la synthèse de la paroi cellulaire et provoquant la mort des cellules bactériennes.
Dosage & Administration
Adulte : PO Infections sensibles 1 à 2 g/jour à diviser en 2 à 4 prises. Max : 4 g/jour.
IV/IM Infections sévères 2 à 4 g/jour en doses fractionnées. Max : 8 g/jour.
Prophylaxie chirurgicale 1-2 g préopératoire. Des doses ultérieures peuvent être administrées si nécessaire.
Peau et structures cutanées et infection des voies respiratoires : La dose habituelle est de 250 mg toutes les 6 heures ou de 500 mg toutes les 12 heures.
Pneumonie lobaire : 500 mg toutes les 6 heures ou 1 g toutes les 12 heures.
Infection des voies urinaires : La dose habituelle est de 500 mg toutes les 12 heures.
Infection du tractus gastro-intestinal : 500 mg trois à quatre fois par jour.
Enfants : Orale : La dose totale habituelle est de 25 à 50 mg/kg/jour, administrée en 2 à 4 doses également divisées.
Injection : 50 à 100 mg/kg/jour en 4 prises égales. La dose totale habituelle peut être augmentée jusqu'à 200-300 mg/kg/jour.
Prophylaxie périopératoire : la dose recommandée est de 1 à 2 g par voie intramusculaire ou intraveineuse ; Des doses parentérales ou orales ultérieures sont administrées selon le cas.
Insuffisance rénale : Pour les patients soumis à une hémodialyse chronique intermittente : 250 mg peuvent être administrés au début de la séance, répétés après 6 à 12 heures, puis à nouveau 36 à 48 heures après la dose initiale, et de nouveau au début de l'hémodialyse suivante si > 30 heures se sont écoulées depuis la dose précédente.
ClCr (ml/min)
>20 500 mg toutes les 6 heures.
5-20 250 mg toutes les 6 heures.
Pregnancy & Lactation
Bien que les études sur la reproduction animale aient montré un effet indésirable, même parfois sans pouvoir démontrer le risque pour le fœtus et qu'il n'existe pas d'études adéquates et bien contrôlées chez la femme enceinte, ce médicament peut être utilisé pendant la grossesse juste en cas de nécessité absolue.
Discutez avec vos médecins et faites-leur part de vos commentaires sur ce médicament.
Il n'existe aucune information spécifique indiquant si ce médicament est transmis au bébé par le lait maternel. Discutez-en avec votre médecin avant d'allaiter.
Pack Size & Price
100ml bot Price : ৳120
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