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Bisocor Plus 5/6.25 (Tablet)

Manufactured by: Square Pharmaceuticals Ltd.

Bisoprolol + Hydrochlorothiazide Similar medicine

Bisocor Plus 5/6.25 is indicated for

  • Hypertension
  • Congestive heart failure
  • HTN
  • Angina pectoris

Precautions and warnings

Certain people on thiazide diuretics may develop hyperuricemia or severe gout. Dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular tiredness, hypotension, oliguria, tachycardia, and gastrointestinal disturbances such as nausea and vomiting are all warning indications or symptoms of fluid and electrolyte imbalance. Hypokalemia can occur. If you want to stop taking this combo therapy, you should do so gradually over a two-week period. Patients should be closely monitored.

Side-effects

  • Giddiness
  • headache
  • fatigue
  • bradycardia. Nausea
  • vomiting
  • diarrhoea or constipation
  • stomach discomfort
  • mild ocular stinging
  • photophobia
  • keratitis
  • decreased sexual ability. GI disturbances
  • dyspnoea
  • cold extremities
  • insomnia
  • hallucination
  • drowsiness
  • mood alterations. Potentially Fatal: AV block
  • bradycardia. Rare but may occur in patients with preexisting cardiac disease. Includes severe bronchospasm
  • hypoglycaemia
  • hypotension
  • orthostatic hypotension
  • bradyarrhythmias. 'Rebound phenomenon' leading to unstable angina or MI on sudden withdrawal.

Drug Interactions

This combination medicine may enhance the effects of other antihypertensive medications used at the same time. Other beta-blocking medications should not be taken with this combo therapy. Patients using catecholamine-depleting medicines like reserpine or guanethidine should be constantly watched because Bisoprolol Fumarate's additional beta-adrenergic blocking action may cause an excessive reduction in sympathetic activity. If clonidine therapy is to be stopped, it is recommended that this combo medicine be stopped for many days before the clonidine is stopped. When cardiac depressants or inhibitors of AV conduction, such as calcium antagonists (especially of the phenylethylamine [verapamil] and benzothiazepine [diltiazem] classes) or antiarrhythmic medicines, such as disopyramide, are administered concurrently, this combination medication should be used with caution. Beta-blockers and digitalis glycosides both delay atrioventricular conduction and lower heart rate. Concurrent use can put you at risk for bradycardia.

Contraindications

Cardiogenic shock, overt heart failure, second or third-degree AV block, significant sinus bradycardia, anuria, and hypersensitivity to any component of this medication or other sulfonamide-derived pharmaceuticals are all contraindications.

Mode of actions

Bisoprolol fumarate/hydrochlorothiazide is a fixed-combination pill that contains bisoprolol fumarate, a Beta adrenergic receptor blocker, and hydrochlorothiazide, a thiazide diuretic.

Bisoprolol fumarate, a beta(1)-adrenoceptor cardioselective inhibitor, has no inherent sympathomimetic or membrane-stabilizing activity in therapeutic doses, but inhibits beta(2)-adrenoceptors and has a negative chronotropic impact.

The thiazide diuretic hydrochlorothiazide inhibits Na reabsorption in the distal renal tubules, resulting in increased excretion of Na+, water, as well as K+ and H+ ions.

Dosage & Administration

Adult: PO Initial: 2.5 mg/6.25 mg tablet once daily.

Increase based on clinical response in 2 weeks, Maximum: bisoprolol 20 mg/hydrochlorothiazide 12.5 mg once daily.

Pregnancy & Lactation

This medicine is not allowed during pregnancy. Do not use it if you are pregnant. It can be absorbed through the skin and lungs caused can damage your unborn child’s organs and cause congenital disabilities. Strict effective birth control during treatment and for six months after stopping this medicine. If you do become pregnant, stop taking this medicine and discuss your doctor right away.

There is no specific information on whether this medicine passes into breast milk or not. Considering the possible risks for the children, breastfeeding while using this medicine is not recommended and at least two weeks after the last dose. Consult your doctor before breastfeeding.

Pack Size & Price

30's pack Price : ৳300

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Click here to see 11 more similar medicines

There are few similar medicines of Bisocor Plus 5/6.25 are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.

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