Bugesic 200 mcg (Tablet)
Manufactured by: Beximco Pharmaceuticals Ltd.
Buprenorphine Similar medicine
Bugesic is indicated for
- Pain
- Anaesthesia
- Opioid dependence
Precautions and warnings
Hepatic or renal disease, a pregnant woman, a mother who breastfeeds her baby, hypothyroidism, adrenocortical insufficiency, asthma, prostatic hyperplasia, shock, hypotension, inflammatory or obstructive bowel disorders, myasthenia gravis, infants/neonates, hypothyroidism, adrenocortical insufficiency, asthma, prostatic hyperplasia, Patients who are elderly or handicapped should take a lower dose. In narcotic users, it may exacerbate withdrawal symptoms.
Side-effects
- Sedation
- nausea
- dizziness
- vertigo
- hypotension
- miosis
- headache
- hypoventilation
- resp or CNS depression; tachycardia
- bradycardia
- urinary retention
- coma
- vomiting
- drowsiness
- sweating
- confusion
- dry mouth
- diaphoresis
- withdrawal syndrome.
Drug Interactions
When used with medicines that increase or inhibit the cytochrome P450 isoenzyme CYP3A4, plasma-buprenorphine concentrations may be altered. Other CNS depressants, such as alcohol, anesthetics, anxiolytics, hypnotics, TCAs, and antipsychotics, have enhanced depressant effects.
Diazepam can cause respiratory and cardiac collapse, which can be fatal.
Contraindications
Patients on established opioid agonists, acute drunkenness, convulsive disorders, head injuries, elevated intracranial pressure, comatose patients, resp depression, and obstructive airway disease.
Mode of actions
Buprenorphine works as an analgesic by attaching to mu-opioid receptors in the central nervous system. Its analgesic effect lasts longer than that of morphine. It has a minimal level of physical dependence due to its partial agonist action. Buprenorphine and morphine have similar dose-dependent effects on the respiratory system.
Dosage & Administration
Adult: Sublingual Moderate to severe pain 200-400 mcg 6-8 hrly. IV Perioperative analgesia 300-450 mcg via slow inj. IV/IM Moderate to severe pain 300-600 mcg 6-8 hrly. IM Anesth premed 300 mcg.
Pregnancy & Lactation
Although animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in pregnant women, but during pregnancy, this medicine can be used just when definitely required despite potential risks.
Mothers with a newborn baby who have used this drug during the last 3 months of pregnancy may seldom create symptoms including drowsiness, muscle stiffness or shakiness, feeding or breathing troubles, constant crying. If you notice any of these symptoms of your baby's particularly during their first month, tell the doctor immediately.
This medicine passes into breast milk. Talk to your doctor before breastfeeding.
Pack Size & Price
Price : ৳
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There are few similar medicines of Bugesic are manufactured by other companies using the same ingredients. Although, it would be good if you are able to use the same medicine, which has been prescribed by your Doctor. Due to availability in the local market, you can try others. Please make sure and contact your Doctor first about alternatives.
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