Xenosal (0.05 gm + 3 gm)/100 gm (Ointment)
Manufactured by: Unimed & Unihealth Manufacturers Ltd.
Clobetasol Propionate 0.05% + Salicylic Acid 3% Similar medicine
Xenosal is indicated for
- Psoriasis
- Luka Bakar
- Jerawat vulgaris
- Eksim
- Diskeratosis
- Iktiosis
- Kutil
- Hiperkeratosis
- Jagung
- Kalus
- Seborrhea
- Penyakit kulit bersisik
- Rambut rontok
- Kaki berkeringat
- Dermatitis
Precautions and warnings
Jangan menggunakan produk ini dalam jumlah banyak atau pada area tubuh yang luas dalam waktu lama. Jika Anda memiliki sirkulasi darah yang buruk atau diabetes, berhati-hatilah. Jangan mengaplikasikannya pada kulit yang rusak, bagian dalam mulut, mata, selaput lendir, atau area genital dan anus.
Side-effects
- Penggunaan jangka panjang dari clobetasol propionate dalam jumlah besar dapat menyebabkan tingkat sistemik yang cukup untuk menghasilkan penekanan adrenal
- sindrom Cushing
- diabetes dan hipertensi. Atrofi dermal dan epidermal terutama pada wajah
- purpura steroid
Drug Interactions
Clobetasol Propionate: Mengonsumsi obat ini dengan inhibitor CYP3A4 (seperti ritonavir atau itraconazole) dapat meningkatkan jumlah clobetasol dalam tubuh Anda.
Mode of actions
**Kortikosteroid** mengurangi peradangan dengan beberapa cara. Mereka menjaga membran sel kekebalan tertentu tetap stabil sehingga enzim berbahaya tidak dilepaskan, menghentikan berkumpulnya makrofag di tempat yang meradang, dan mempersulit sel darah putih menempel pada dinding pembuluh darah. Obat ini juga mengurangi mudahnya cairan keluar dari pembuluh darah, sehingga membantu mencegah pembengkakan, dan menurunkan kadar protein yang terlibat dalam respons imun. Selain itu, kortikosteroid memblokir efek histamin dan mengurangi pelepasan kinin, yang keduanya terlibat dalam peradangan. Mereka juga memperlambat aktivitas sel (fibroblas) yang memproduksi kolagen dan jaringan parut.
**Asam salisilat** bekerja terutama dengan memecah dan melembutkan lapisan luar kulit (stratum korneum) saat dioleskan pada kulit. Ini meningkatkan kelembapan pada kulit, yang menyebabkan lapisan ini membengkak, melunak, dan akhirnya terkelupas. Dalam jumlah banyak, asam salisilat justru bisa membakar kulit. Selain itu, ia memiliki sifat antibakteri dan antijamur ringan.
Dosage & Administration
Dewasa: Jerawat Topikal; Kondisi kulit hiperkeratosis dan bersisik Sebagai sediaan 2-6%: Oleskan >3 kali/hari. Kutil dan kapalan Sebagai persiapan 60%: Terapkan sesuai petunjuk.
Pregnancy & Lactation
Meskipun penelitian pada reproduksi hewan menunjukkan efek buruk pada janin dan belum ada penelitian yang memadai dan terkontrol dengan baik pada wanita hamil, namun selama kehamilan, obat ini dapat digunakan tepat ketika benar-benar diperlukan meskipun ada potensi risikonya.
Ibu dengan bayi baru lahir yang telah menggunakan obat ini selama 3 bulan terakhir kehamilan mungkin jarang mengalami gejala termasuk mengantuk, otot kaku atau gemetar, kesulitan makan atau bernapas, dan menangis terus-menerus. Jika Anda melihat gejala-gejala ini pada bayi Anda terutama pada bulan pertama, segera beri tahu dokter.
Obat ini masuk ke dalam ASI. Bicaralah dengan dokter Anda sebelum menyusui.
Pack Size & Price
Price : ৳
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Manufactured by: Unimed & Unihealth Manufacturers Ltd.
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