Micinagen 80mg/2ml (Injection)
Manufactured by: Sanofi Aventis (BD) Ltd.
Gentamicin Similar medicine
Micinagen is indicated for
- Pneumonie
- mucoviscidose
- méningite
- péritonite
- endocardite
- infections sensibles
- septicémie
- maladie inflammatoire pelvienne
- endométrite
- infections des voies biliaires
- granulome inguinal
- listériose
- gastro-entérite
- peste
- maladie des griffes du chat
- brucellose
- otite externe
- infections chirurgicales
- infections cutanées.
Precautions and warnings
N'utilisez pas ce médicament si vous avez déjà eu une réaction allergique aux aminosides, si vous êtes enceinte, si vous avez des problèmes de foie ou si vous avez un tympan perforé (cassé).
Side-effects
- Étourdissements ou vertiges ; insuffisance rénale aiguë
- néphrite interstitielle
- nécrose tubulaire aiguë ; déséquilibres électrolytiques; élévation transitoire de la bilirubine sérique et des aminotransférases ; purpura; nausées
- vomissements; convulsions
- dépression mentale
- hallucinations. Atrophie ou nécrose du rat au niveau des sites d'injection. Potentiellement mortel : néphrotoxicité
- ototoxicité et blocage neuromusculaire (peut démasquer ou aggraver la myasthénie grave).
Drug Interactions
Ce médicament fonctionne bien avec l'ampicilline, la benzylpénicilline et d'autres antibiotiques bêta-lactamines. Son utilisation avec des anesthésiques ou des opioïdes peut augmenter le risque de graves problèmes respiratoires. Il peut également réduire la quantité de zalcitabine éliminée par les reins et entraîner de faibles taux de calcium s'il est pris avec des bisphosphonates. N'utilisez pas ce médicament avec l'agalsidase alfa ou bêta, car cela pourrait bloquer l'action de la β-galactosidase.
Avertissements sérieux : Il existe un risque plus élevé de lésions auditives (ototoxicité) s'il est pris avec de l'acide éthacrynique ou du furosémide. Le risque de lésions rénales (néphrotoxicité) est augmenté en cas d'association avec des céphalosporines, de la ciclosporine, du cisplatine, de la vancomycine, de l'hydrocortisone ou de l'indométacine. Ce médicament peut également rendre les médicaments relaxants musculaires (bloquants neuromusculaires) plus efficaces.
Contraindications
Ne pas utiliser si vous avez des antécédents d'allergie aux aminosides, si vous êtes enceinte, si vous avez des problèmes de foie ou si vous avez une rupture du tympan.
Mode of actions
La gentamicine est un antibiotique aminoglycoside qui se fixe aux parties 30 et 50 du ribosome d’une bactérie. Cela empêche les bactéries de produire correctement des protéines, ce qui endommage leur membrane cellulaire et aide à tuer les bactéries.
Dosage & Administration
Adulte : Infections sensibles IM 3 à 5 mg/kg/jour en doses divisées 8 heures pendant 7 à 10 jours. Prophylaxie chirurgicale 120 mg avant l'induction de l'anesthésie, avec pénicilline, vancomycine ou teicoplanine.
Pédiatrique
Jusqu'à 2 semaines : 3 mg/kg/toutes les 12 heures
2 semaines à 12 ans : 2 mg/kg/toutes les 8 heures ou selon les directives du médecin.
Insuffisance rénale : Hémodialyse : Administrer la dose après la séance de dialyse et surveiller les niveaux.
ClCr (ml/min)
>60 Administrer toutes les 8 heures.
40-60 Administrer toutes les 12 heures.
20-40 Administrer toutes les 24 heures.
Pregnancy & Lactation
Ce médicament est interdit pendant la grossesse. Ne l'utilisez pas si vous êtes enceinte. Il peut être absorbé par la peau et les poumons, ce qui peut endommager les organes de votre enfant à naître et provoquer des handicaps congénitaux. Contrôle des naissances strict et efficace pendant le traitement et pendant six mois après l'arrêt de ce médicament. Si vous tombez enceinte, arrêtez de prendre ce médicament et parlez-en immédiatement à votre médecin.
Il n'existe aucune information spécifique indiquant si ce médicament passe ou non dans le lait maternel. Compte tenu des risques possibles pour les enfants, l'allaitement pendant l'utilisation de ce médicament est déconseillé et ce au moins deux semaines après la dernière dose. Consultez votre médecin avant d'allaiter.
Pack Size & Price
25's pack Price : ৳
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