Aldonist 25mg (Tablet)
Manufactured by: Unimed & Unihealth Manufacturers Ltd.
Eplerenone Similar medicine
Aldonist is indicated for
- 高血壓、心臟衰竭、充血性心臟衰竭、左心室功能不全、急性心肌梗塞
Precautions and warnings
在開始治療前、第一週以及之後定期檢查血清鉀濃度。 患有腎臟問題的人、心臟病發作後心臟衰竭的糖尿病患者（特別是尿液中含有蛋白質）或服用其他影響腎素-血管緊張素-醛固酮系統的藥物的人，出現高鉀水平的風險較高。 這種治療方法的安全性和有效性尚未在患有嚴重肝臟問題的患者或兒童中得到證實。
Side-effects
- 高血鉀、低血鈉、頭暈、頭痛、腹痛、腹瀉、咳嗽、疲勞、流感樣症狀、陰道異常出血、男性乳房發育、乳痛、心肌梗塞、心絞痛、高膽固醇血症、高三酸甘油脂血症、白蛋白尿、肌酸酐升高、肝酵素升高、尿酸升高、皮疹和血管神經性水腫。
Drug Interactions
將依普利酮與 CYP3A4 抑制劑（如酮康唑、伏立康唑、伊曲康唑、氟康唑、克拉黴素、地爾硫卓、沙奎那韋、維拉帕米或利托那韋）一起服用可能會增加血液中依普利酮的含量。 另一方面，CYP3A4 誘導劑（如利福平、卡馬西平、苯妥英或苯巴比妥）會降低依普利酮的療效。
依普利農與 ACE 抑制劑、血管張力素 II 受體阻斷劑、保鉀利尿劑或鉀補充劑一起服用時，會增加高鉀水平的風險。
依普利農與二氮嗪、MAOIs、己酮可可鹼或前列環素類似物一起服用可能會增強其他抗高血壓藥物的降血壓作用。
非類固醇抗發炎藥可能會降低保鉀利尿劑的降血壓和利尿作用，並且還會增加高鉀水平的風險。
有報告指出，與 ACE 抑制劑或利尿劑一起使用時，鋰會產生毒性，因此，如果與依普利酮一起使用，監測鋰含量非常重要。
Contraindications
**對於所有患者：**
如果患者開始時血鉀濃度高於 5.5 mEq/L、肌酸酐清除率 (CrCl) 為 30 mL/min 或更低，或正在服用強效 CYP3A4 抑制劑（如酮康唑、伊曲康唑、奈法唑酮、醋竹桃黴素、克拉黴素、利托那韋或奈非那韋），請勿使用。
**對於正在接受高血壓治療的患者：**
患有第 2 型糖尿病和微量白蛋白尿的患者、男性血清肌酸酐高於 2 mg/dL、女性血清肌酸酐高於 1.8 mg/dL、CrCl 低於 30 mL/min 的患者請勿使用。
Mode of actions
醛固酮附著於上皮組織（如腎臟和消化系統）和非上皮組織（如心臟、血管和大腦）中發現的鹽皮質激素受體。 這會導致身體重新吸收更多的鈉、保留更多的水、改變血管的結構等，導致血壓升高。 依普利酮是一種專門阻斷這些鹽皮質激素受體的藥物，阻止醛固酮發揮作用並降低血壓。 它似乎也有助於保護心臟病發作後充血性心臟衰竭患者的心臟。
Dosage & Administration
成人：PO CHF MI 後初始：25 mg，每日一次；根據耐受情況，在 4 週內滴定至建議劑量 50 mg，每日一次。 根據血鉀水平調整劑量；如果出現高血鉀症，則減少或停止治療。
HTN 初始：50 mg，每日一次；根據反應，可能增加至 50 毫克，每天兩次。 如果與中度 CYP3A4 抑制劑同時使用，則以較低劑量 25 mg 每日一次開始。
Pregnancy & Lactation
儘管動物生殖研究顯示出不良影響，甚至有時無法證明對胎兒的風險，並且在孕婦中沒有充分和良好對照的研究，但在懷孕期間，這種藥物可以在確實需要時使用。
與您的醫生討論並告訴他們有關該藥物的意見。
目前還沒有關於這種藥物是否透過母乳傳染給嬰兒的具體資訊。 哺乳前請與您的醫師討論。
Pack Size & Price
28's pack Price : ৳1260
Similar medicine
Manufactured by: Unimed & Unihealth Manufacturers Ltd.
Manufactured by: Incepta Pharmaceuticals Ltd.
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